Search Results - "Agerbæk, Mette Ø."

Author Correction: The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner by Agerbæk, Mette Ø., Bang-Christensen, Sara R., Yang, Ming-Hsin, Clausen, Thomas M., Pereira, Marina A., Sharma, Shreya, Ditlev, Sisse B., Nielsen, Morten A., Choudhary, Swati, Gustavsson, Tobias, Sorensen, Poul H., Meyer, Tim, Propper, David, Shamash, Jonathan, Theander, Thor G., Aicher, Alexandra, Daugaard, Mads, Heeschen, Christopher, Salanti, Ali

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An Oncofetal Glycosaminoglycan Modification Provides Therapeutic Access to Cisplatin-resistant Bladder Cancer by Seiler, Roland, Oo, Htoo Zarni, Tortora, Davide, Clausen, Thomas M, Wang, Chris K, Kumar, Gunjan, Pereira, Marina Ayres, Ørum-Madsen, Maj S, Agerbæk, Mette Ø, Gustavsson, Tobias, Nordmaj, Mie A, Rich, Jamie R, Lallous, Nada, Fazli, Ladan, Lee, Sherry S, Douglas, James, Todenhöfer, Tilman, Esfandnia, Shaghayegh, Battsogt, Dulguun, Babcook, John S, Al-Nakouzi, Nader, Crabb, Simon J, Moskalev, Igor, Kiss, Bernhard, Davicioni, Elai, Thalmann, George N, Rennie, Paul S, Black, Peter C, Salanti, Ali, Daugaard, Mads

“…Abstract Background Although cisplatin-based neoadjuvant chemotherapy (NAC) improves survival of unselected patients with muscle-invasive bladder cancer…”
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The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner by Agerbæk, Mette Ø., Bang-Christensen, Sara R., Yang, Ming-Hsin, Clausen, Thomas M., Pereira, Marina A., Sharma, Shreya, Ditlev, Sisse B., Nielsen, Morten A., Choudhary, Swati, Gustavsson, Tobias, Sorensen, Poul H., Meyer, Tim, Propper, David, Shamash, Jonathan, Theander, Thor G., Aicher, Alexandra, Daugaard, Mads, Heeschen, Christopher, Salanti, Ali

“…Isolation of metastatic circulating tumor cells (CTCs) from cancer patients is of high value for disease monitoring and molecular characterization. Despite the…”
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Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein by Salanti, Ali, Clausen, Thomas M., Agerbæk, Mette Ø., Al Nakouzi, Nader, Dahlbäck, Madeleine, Oo, Htoo Z., Lee, Sherry, Gustavsson, Tobias, Rich, Jamie R., Hedberg, Bradley J., Mao, Yang, Barington, Line, Pereira, Marina A., LoBello, Janine, Endo, Makoto, Fazli, Ladan, Soden, Jo, Wang, Chris K., Sander, Adam F., Dagil, Robert, Thrane, Susan, Holst, Peter J., Meng, Le, Favero, Francesco, Weiss, Glen J., Nielsen, Morten A., Freeth, Jim, Nielsen, Torsten O., Zaia, Joseph, Tran, Nhan L., Trent, Jeff, Babcook, John S., Theander, Thor G., Sorensen, Poul H., Daugaard, Mads

“…Plasmodium falciparum engineer infected erythrocytes to present the malarial protein, VAR2CSA, which binds a distinct type chondroitin sulfate (CS) exclusively…”
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Fighting Cancer Using an Oncofetal Glycosaminoglycan-Binding Protein from Malaria Parasites by Agerbæk, Mette Ø., Bang-Christensen, Sara, Salanti, Ali

“…Malaria research has led to the discovery of oncofetal chondroitin sulfate, which appears to be shared between placental trophoblasts and cancer cells and can…”
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Combined microfluidic enrichment and staining workflow for single-cell analysis of circulating tumor cells in metastatic prostate cancer patients by Løppke, Caroline, Jørgensen, Amalie M., Sand, Nicolai T., Klitgaard, Rasmus B., Daugaard, Gedske, Agerbæk, Mette Ø.

“…Circulating tumor cells (CTCs) are precursors of cancer in the blood and provide an attractive source for dynamic monitoring of disease progression and tumor…”
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Combining rVAR2 and Anti-EpCAM to Increase the Capture Efficiency of Non-Small-Cell Lung Cancer Cell Lines in the Flow Enrichment Target Capture Halbach (FETCH) Magnetic Separation System by He, Sitian, Liu, Peng, Wu, Yongjun, Agerbæk, Mette Ø, Salanti, Ali, Terstappen, Leon W M M, Jonkheijm, Pascal, Stevens, Michiel

“…Circulating tumor cells (CTCs) are detected in approximately 30% of metastatic non-small-cell lung cancer (NSCLC) cases using the CellSearch system, which…”
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Structural and Functional Insight into How the Plasmodium falciparum VAR2CSA Protein Mediates Binding to Chondroitin Sulfate A in Placental Malaria by Clausen, Thomas M., Christoffersen, Stig, Dahlbäck, Madeleine, Langkilde, Annette Eva, Jensen, Kamilla E., Resende, Mafalda, Agerbæk, Mette Ø., Andersen, Daniel, Berisha, Besim, Ditlev, Sisse B., Pinto, Vera V., Nielsen, Morten A., Theander, Thor G., Larsen, Sine, Salanti, Ali

“…Malaria is a major global health problem. Pregnant women are susceptible to infection regardless of previously acquired immunity. Placental malaria is caused…”
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A Novel Virus-Like Particle Based Vaccine Platform Displaying the Placental Malaria Antigen VAR2CSA by Thrane, Susan, Janitzek, Christoph M, Agerbæk, Mette Ø, Ditlev, Sisse B, Resende, Mafalda, Nielsen, Morten A, Theander, Thor G, Salanti, Ali, Sander, Adam F

“…Placental malaria caused by Plasmodium falciparum is a major cause of mortality and severe morbidity. Clinical testing of a soluble protein-based vaccine…”
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The Role of Proteoglycans in Cancer Metastasis and Circulating Tumor Cell Analysis by Ahrens, Theresa D, Bang-Christensen, Sara R, Jørgensen, Amalie M, Løppke, Caroline, Spliid, Charlotte B, Sand, Nicolai T, Clausen, Thomas M, Salanti, Ali, Agerbæk, Mette Ø

“…Circulating tumor cells (CTCs) are accessible by liquid biopsies via an easy blood draw. They represent not only the primary tumor site, but also potential…”
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Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding by Wang, Kaituo, Dagil, Robert, Lavstsen, Thomas, Misra, Sandeep K., Spliid, Charlotte B., Wang, Yong, Gustavsson, Tobias, Sandoval, Daniel R., Vidal-Calvo, Elena Ethel, Choudhary, Swati, Agerbaek, Mette Ø, Lindorff-Larsen, Kresten, Nielsen, Morten A., Theander, Thor G., Sharp, Joshua S., Clausen, Thomas Mandel, Gourdon, Pontus, Salanti, Ali

“…Placental malaria can have severe consequences for both mother and child and effective vaccines are lacking. Parasite-infected red blood cells sequester in the…”
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The Influence of Sub-Unit Composition and Expression System on the Functional Antibody Response in the Development of a VAR2CSA Based Plasmodium falciparum Placental Malaria Vaccine by Nielsen, Morten A, Resende, Mafalda, de Jongh, Willem A, Ditlev, Sisse B, Mordmüller, Benjamin, Houard, Sophie, Ndam, Nicaise Tuikue, Agerbæk, Mette Ø, Hamborg, Mette, Massougbodji, Achille, Issifou, Saddou, Strøbæk, Anette, Poulsen, Lars, Leroy, Odile, Kremsner, Peter G, Chippaux, Jean-Philippe, Luty, Adrian J F, Deloron, Philippe, Theander, Thor G, Dyring, Charlotte, Salanti, Ali

“…The disease caused by Plasmodium falciparum (Pf) involves different clinical manifestations that, cumulatively, kill hundreds of thousands every year…”
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Oncofetal Chondroitin Sulfate Glycosaminoglycans Are Key Players in Integrin Signaling and Tumor Cell Motility by Clausen, Thomas Mandel, Pereira, Marina Ayres, Al Nakouzi, Nader, Oo, Htoo Zarni, Agerbæk, Mette Ø, Lee, Sherry, Ørum-Madsen, Maj Sofie, Kristensen, Anders Riis, El-Naggar, Amal, Grandgenett, Paul M, Grem, Jean L, Hollingsworth, Michael A, Holst, Peter J, Theander, Thor, Sorensen, Poul H, Daugaard, Mads, Salanti, Ali

“…Many tumors express proteoglycans modified with oncofetal chondroitin sulfate glycosaminoglycan chains (ofCS), which are normally restricted to the placenta…”
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Optimization of rVAR2-Based Isolation of Cancer Cells in Blood for Building a Robust Assay for Clinical Detection of Circulating Tumor Cells by Sand, Nicolai T, Petersen, Tobias B, Bang-Christensen, Sara R, Ahrens, Theresa D, Løppke, Caroline, Jørgensen, Amalie M, Gustavsson, Tobias, Choudhary, Swati, Theander, Thor G, Salanti, Ali, Agerbæk, Mette Ø

“…Early detection and monitoring of cancer progression is key to successful treatment. Therefore, much research is invested in developing technologies, enabling…”
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Capture and Detection of Circulating Glioma Cells Using the Recombinant VAR2CSA Malaria Protein by Bang-Christensen, Sara R, Pedersen, Rasmus S, Pereira, Marina A, Clausen, Thomas M, Løppke, Caroline, Sand, Nicolai T, Ahrens, Theresa D, Jørgensen, Amalie M, Lim, Yi Chieh, Goksøyr, Louise, Choudhary, Swati, Gustavsson, Tobias, Dagil, Robert, Daugaard, Mads, Sander, Adam F, Torp, Mathias H, Søgaard, Max, Theander, Thor G, Østrup, Olga, Lassen, Ulrik, Hamerlik, Petra, Salanti, Ali, Agerbæk, Mette Ø

“…Diffuse gliomas are the most common primary malignant brain tumor. Although extracranial metastases are rarely observed, recent studies have shown the presence…”
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CTC-derived pancreatic cancer models serve as research tools and are suitable for precision medicine approaches by Tang, Jiajia, Zheng, Quan, Wang, Qi, Zhao, Yaru, Ananthanarayanan, Preeta, Reina, Chiara, Šabanović, Berina, Jiang, Ke, Yang, Ming-Hsin, Meny, Clara Csilla, Wang, Huimin, Agerbaek, Mette Ø., Clausen, Thomas Mandel, Gustavsson, Tobias, Wen, Chenlei, Borghi, Felice, Mellano, Alfredo, Fenocchio, Elisabetta, Gregorc, Vanesa, Sapino, Anna, Theander, Thor G., Fu, Da, Aicher, Alexandra, Salanti, Ali, Shen, Baiyong, Heeschen, Christopher

“…Pancreatic ductal adenocarcinoma (PDAC) poses significant clinical challenges, often presenting as unresectable with limited biopsy options. Here, we show that…”
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Detection of VAR2CSA-Captured Colorectal Cancer Cells from Blood Samples by Real-Time Reverse Transcription PCR by Bang-Christensen, Sara R., Katerov, Viatcheslav, Jørgensen, Amalie M., Gustavsson, Tobias, Choudhary, Swati, Theander, Thor G., Salanti, Ali, Allawi, Hatim T., Agerbæk, Mette Ø.

“…Analysis of circulating tumor cells (CTCs) from blood samples provides a non-invasive approach for early cancer detection. However, the rarity of CTCs makes it…”
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Burkitt lymphoma expresses oncofetal chondroitin sulfate without being a reservoir for placental malaria sequestration by Agerbæk, Mette Ø., Pereira, Marina A., Clausen, Thomas M., Pehrson, Caroline, Oo, Htoo Zarni, Spliid, Charlotte, Rich, Jamie R., Fung, Vincent, Nkrumah, Francis, Neequaye, Janet, Biggar, Robert J., Reynolds, Steven J., Tosato, Giovanna, Pullarkat, Sheeja T., Ayers, Leona W., Theander, Thor G., Daugaard, Mads, Bhatia, Kishor, Nielsen, Morten A., Mbulaiteye, Sam M., Salanti, Ali

“…Burkitt lymphoma (BL) is a malignant disease, which is frequently found in areas with holoendemic Plasmodium falciparum malaria. We have previously found that…”
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A simple method for detecting oncofetal chondroitin sulfate glycosaminoglycans in bladder cancer urine by Clausen, Thomas Mandel, Kumar, Gunjan, Ibsen, Emilie K., Ørum-Madsen, Maj S., Hurtado-Coll, Antonio, Gustavsson, Tobias, Agerbæk, Mette Ø., Gatto, Francesco, Todenhöfer, Tilman, Basso, Umberto, Knowles, Margaret A., Sanchez-Carbayo, Marta, Salanti, Ali, Black, Peter C., Daugaard, Mads

“…Proteoglycans in bladder tumors are modified with a distinct oncofetal chondroitin sulfate (ofCS) glycosaminoglycan that is normally restricted to placental…”
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Tumor-agnostic cancer therapy using antibodies targeting oncofetal chondroitin sulfate by Vidal-Calvo, Elena Ethel, Martin-Salazar, Anne, Choudhary, Swati, Dagil, Robert, Raghavan, Sai Sundar Rajan, Duvnjak, Lara, Nordmaj, Mie Anemone, Clausen, Thomas Mandel, Skafte, Ann, Oberkofler, Jan, Wang, Kaituo, Agerbæk, Mette Ø, Løppke, Caroline, Jørgensen, Amalie Mundt, Ropac, Daria, Mujollari, Joana, Willis, Shona, Garcias López, Agnès, Miller, Rebecca Louise, Karlsson, Richard Torbjörn Gustav, Goerdeler, Felix, Chen, Yen-Hsi, Colaço, Ana R., Wang, Yong, Lavstsen, Thomas, Martowicz, Agnieszka, Nelepcu, Irina, Marzban, Mona, Oo, Htoo Zarni, Ørum-Madsen, Maj Sofie, Wang, Yuzhuo, Nielsen, Morten A., Clausen, Henrik, Wierer, Michael, Wolf, Dominik, Gögenur, Ismail, Theander, Thor G., Al-Nakouzi, Nader, Gustavsson, Tobias, Daugaard, Mads, Salanti, Ali

“…Molecular similarities between embryonic and malignant cells can be exploited to target tumors through specific signatures absent in healthy adult tissues. One…”
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