Search Results - "Agell, Neus"

RAD51 is a druggable target that sustains replication fork progression upon DNA replication stress by Feu, Sonia, Unzueta, Fernando, Ercilla, Amaia, Pérez-Venteo, Alejandro, Jaumot, Montserrat, Agell, Neus

“…Solving the problems that replication forks encounter when synthesizing DNA is essential to prevent genomic instability. Besides their role in DNA repair in…”
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Acute hydroxyurea-induced replication blockade results in replisome components disengagement from nascent DNA without causing fork collapse by Ercilla, Amaia, Feu, Sonia, Aranda, Sergi, Llopis, Alba, Brynjólfsdóttir, Sólveig Hlín, Sørensen, Claus Storgaard, Toledo, Luis Ignacio, Agell, Neus

“…During S phase, replication forks can encounter several obstacles that lead to fork stalling, which if persistent might result in fork collapse. To avoid this…”
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Near‐tetraploid cancer cells show chromosome instability triggered by replication stress and exhibit enhanced invasiveness by Wangsa, Darawalee, Quintanilla, Isabel, Torabi, Keyvan, Vila‐Casadesús, Maria, Ercilla, Amaia, Klus, Gregory, Yuce, Zeynep, Galofré, Claudia, Cuatrecasas, Miriam, José Lozano, Juan, Agell, Neus, Cimini, Daniela, Castells, Antoni, Ried, Thomas, Camps, Jordi

“…A considerable proportion of tumors exhibit aneuploid karyotypes, likely resulting from the progressive loss of chromosomes after whole‐genome duplication…”
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Pleiotropic Roles of Calmodulin in the Regulation of KRas and Rac1 GTPases: Functional Diversity in Health and Disease by Tebar, Francesc, Chavero, Albert, Agell, Neus, Lu, Albert, Rentero, Carles, Enrich, Carlos, Grewal, Thomas

“…Calmodulin is a ubiquitous signalling protein that controls many biological processes due to its capacity to interact and/or regulate a large number of…”
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Modeling and subtleties of K-Ras and Calmodulin interaction by Garrido, Eduardo, Lázaro, Juan, Jaumot, Montserrat, Agell, Neus, Rubio-Martinez, Jaime

“…K-Ras, one of the most common small GTPases of the cell, still presents many riddles, despite the intense efforts to unveil its mysteries. Such is the case of…”
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KRAS phosphorylation regulates cell polarization and tumorigenic properties in colorectal cancer by Cabot, Débora, Brun, Sònia, Paco, Noelia, Ginesta, Mireia M., Gendrau-Sanclemente, Núria, Abuasaker, Baraa, Ruiz-Fariña, Triana, Barceló, Carles, Cuatrecasas, Miriam, Bosch, Marta, Rentero, Carles, Pons, Gabriel, Estanyol, Josep M., Capellà, Gabriel, Jaumot, Montserrat, Agell, Neus

“…Oncogenic mutations of KRAS are found in the most aggressive human tumors, including colorectal cancer. It has been suggested that oncogenic KRAS…”
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Peptidomimetics designed to bind to RAS effector domain are promising cancer therapeutic compounds by Pallara, Chiara, Cabot, Debora, Rivas, Josep, Brun, Sonia, Seco, Jesús, Abuasaker, Baraa, Tarragó, Teresa, Jaumot, Montserrat, Prades, Roger, Agell, Neus

“…Oncogenic RAS proteins are important for driving tumour formation, and for maintenance of the transformed phenotype, and thus their relevance as a cancer…”
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α4-α5 Helices on Surface of KRAS Can Accommodate Small Compounds That Increase KRAS Signaling While Inducing CRC Cell Death by Abuasaker, Baraa, Garrido, Eduardo, Vilaplana, Marta, Gómez-Zepeda, Jesús Daniel, Brun, Sonia, Garcia-Cajide, Marta, Mauvezin, Caroline, Jaumot, Montserrat, Pujol, Maria Dolors, Rubio-Martínez, Jaime, Agell, Neus

“…KRAS is the most frequently mutated oncogene associated with the genesis and progress of pancreatic, lung and colorectal (CRC) tumors. KRAS has always been…”
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Phosphorylation at Ser-181 of Oncogenic KRAS Is Required for Tumor Growth by BARCELO, Carles, PACO, Noelia, MORELL, Mireia, ALVAREZ-MOYA, Blanca, BOTA-RABASSEDAS, Neus, JAUMOT, Montserrat, VILARDELL, Felip, CAPELLA, Gabriel, AGELL, Neus

“…KRAS phosphorylation has been reported recently to modulate the activity of mutant KRAS protein in vitro. In this study, we defined S181 as a specific…”
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clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes by Lu, Albert, Tebar, Francesc, Alvarez-Moya, Blanca, López-Alcalá, Cristina, Calvo, Maria, Enrich, Carlos, Agell, Neus, Nakamura, Takeshi, Matsuda, Michiyuki, Bachs, Oriol

“…Ras proteins are small guanosine triphosphatases involved in the regulation of important cellular functions such as proliferation, differentiation, and…”
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Modulation of the Ras/Raf/MEK/ERK pathway by Ca2+, and Calmodulin by Agell, Neus, Bachs, Oriol, Rocamora, Nati, Villalonga, Priam

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SUMO regulates p21Cip1 intracellular distribution and with p21Cip1 facilitates multiprotein complex formation in the nucleolus upon DNA damage by Brun, Sonia, Abella, Neus, Berciano, Maria T, Tapia, Olga, Jaumot, Montserrat, Freire, Raimundo, Lafarga, Miguel, Agell, Neus

“…We previously showed that p21Cip1 transits through the nucleolus on its way from the nucleus to the cytoplasm and that DNA damage inhibits this transit and…”
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p21 as a transcriptional co-repressor of S-phase and mitotic control genes by Ferrándiz, Nuria, Caraballo, Juan M, García-Gutierrez, Lucía, Devgan, Vikram, Rodriguez-Paredes, Manuel, Lafita, M Carmen, Bretones, Gabriel, Quintanilla, Andrea, Muñoz-Alonso, M Jose, Blanco, Rosa, Reyes, Jose C, Agell, Neus, Delgado, M Dolores, Dotto, G Paolo, León, Javier

“…It has been previously described that p21 functions not only as a CDK inhibitor but also as a transcriptional co-repressor in some systems. To investigate the…”
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Identification of Essential Interacting Elements in K-Ras/Calmodulin Binding and Its Role in K-Ras Localization by Lopez-Alcalá, Cristina, Alvarez-Moya, Blanca, Villalonga, Priam, Calvo, Maria, Bachs, Oriol, Agell, Neus

“…We previously showed that K-Ras is a calmodulin-binding protein. Involvement of this interaction in anterograde and retrograde transport of K-Ras was then…”
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Proteasome inhibition reduces proliferation, collagen expression, and inflammatory cytokine production in nasal mucosa and polyp fibroblasts by Pujols, Laura, Fernández-Bertolín, Laura, Fuentes-Prado, Mireya, Alobid, Isam, Roca-Ferrer, Jordi, Agell, Neus, Mullol, Joaquim, Picado, César

“…Proteasome inhibitors, used in cancer treatment for their proapoptotic effects, have anti-inflammatory and antifibrotic effects on animal models of various…”
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The stress-activated protein kinases p38α/β and JNK1/2 cooperate with Chk1 to inhibit mitotic entry upon DNA replication arrest by Llopis, Alba, Salvador, Noelia, Ercilla, Amaia, Guaita-Esteruelas, Sandra, Barrantes, Ivan del Barco, Gupta, Jalaj, Gaestel, Matthias, Davis, Roger J., Nebreda, Angel R., Agell, Neus

“…Accurate DNA replication is crucial for the maintenance of genome integrity. To this aim, cells have evolved complex surveillance mechanisms to prevent mitotic…”
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The SET Protein Regulates G2/M Transition by Modulating Cyclin B-Cyclin-dependent Kinase 1 Activity by Canela, Núria, Rodriguez-Vilarrupla, Aina, Estanyol, Josep Marı́a, Dı́az, Carmen, Pujol, Maria Jesús, Agell, Neus, Bachs, Oriol

“…The SET protein and the cell cycle inhibitor p21Cip1 interact in vivo and in vitro. We identified here the domain157LIF159 of p21Cip1 as essential for the…”
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Calmodulin Binds to K-Ras, but Not to H- or N-Ras, and Modulates Its Downstream Signaling by Villalonga, Priam, López-Alcalá, Cristina, Bosch, Marta, Chiloeches, Antonio, Rocamora, Nativitat, Gil, Joan, Marais, Richard, Marshall, Christopher J., Bachs, Oriol, Agell, Neus

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Ribonucleoprotein HNRNPA2B1 Interacts With and Regulates Oncogenic KRAS in Pancreatic Ductal Adenocarcinoma Cells by Barceló, Carles, Etchin, Julia, Mansour, Marc R, Sanda, Takaomi, Ginesta, Mireia M, Sanchez-Arévalo Lobo, Victor J, Real, Francisco X, Capellà, Gabriel, Estanyol, Josep M, Jaumot, Montserrat, Look, A. Thomas, Agell, Neus

“…Background & Aims Development of pancreatic ductal adenocarcinoma (PDAC) involves activation of c-Ki-ras2 Kirsten rat sarcoma oncogene homolog (KRAS)…”
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CaM interaction and Ser181 phosphorylation as new K-Ras signaling modulators by Alvarez-Moya, Blanca, Barceló, Carles, Tebar, Francesc, Jaumot, Montserrat, Agell, Neus

“…The small G-protein Ras was the first oncogene to be identified and has a very important contribution to human cancer development (20-23% prevalence). K-RasB,…”
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