Search Results - "Ageing research reviews"

The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis by Zheng, Linli, Zhang, Ziji, Sheng, Puyi, Mobasheri, Ali

“…•Osteoarthritis (OA) is the most common form of age-related arthritis and is characterized by low-grade inflammation and metabolic dysfunction.•Aberrant…”
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A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks by Fang, Evandro F., Xie, Chenglong, Schenkel, Joseph A., Wu, Chenkai, Long, Qian, Cui, Honghua, Aman, Yahyah, Frank, Johannes, Liao, Jing, Zou, Huachun, Wang, Ninie Y., Wu, Jing, Liu, Xiaoting, Li, Tao, Fang, Yuan, Niu, Zhangming, Yang, Guang, Hong, Jiangshui, Wang, Qian, Chen, Guobing, Li, Jun, Chen, Hou-Zao, Kang, Lin, Su, Huanxing, Gilmour, Brian C., Zhu, Xinqiang, Jiang, Hong, He, Na, Tao, Jun, Leng, Sean Xiao, Tong, Tanjun, Woo, Jean

“…•Covered broad fields of ageing in China: statistics, basic and translational research, long-term care, policy and social networks.•Provided more detailed…”
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Oxidative stress: The core pathogenesis and mechanism of Alzheimer’s disease by Bai, Renren, Guo, Jianan, Ye, Xiang-Yang, Xie, Yuanyuan, Xie, Tian

“…As the number of patients with Alzheimer’s disease (AD) increases, it brings great suffering to their families and causes a heavy socioeconomic burden to…”
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Markers of inflammation and their association with muscle strength and mass: A systematic review and meta-analysis by Tuttle, Camilla S.L., Thang, Lachlan A.N., Maier, Andrea B.

“…•CRP, IL-6 and TNFα are significantly inversely associated with hand grip and knee extension strength.•Higher CRP levels are significantly inversely associated…”
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Biomarkers, oxidative stress and autophagy in skin aging by Gu, Yanpei, Han, Jianxin, Jiang, Chunpeng, Zhang, Ying

“…•Skin aging is affected by both intrinsic and extrinsic factors.•Skin aging is a highly complex and not fully understood process, and the lack of universal…”
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Ageing, age-related diseases and oxidative stress: What to do next? by Luo, Jiao, Mills, Kevin, le Cessie, Saskia, Noordam, Raymond, van Heemst, Diana

“…•Damage caused by oxidative stress is an important hallmark of ageing.•Whereas experimental work shows clear antioxidant effects, clinical trials failed.•There…”
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A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration by Oblak, Lara, van der Zaag, Jeroen, Higgins-Chen, Albert T., Levine, Morgan E., Boks, Marco P.

“…[Display omitted] •156 publications have reported on factors related to accelerated epigenetic aging.•GrimAge, Hannum, Horvath and Levine clocks tend to agree…”
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Immunosenescence and inflammaging in the aging process: age-related diseases or longevity? by Santoro, Aurelia, Bientinesi, Elisa, Monti, Daniela

“…•Immunosenescence represents a dynamic process describing the changes occurring in the innate and adaptive immune system with age.•Immunosenescence is…”
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The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans by Wilkinson, D J, Piasecki, M, Atherton, P J

“…Age-related loss of skeletal muscle mass and function, sarcopenia, is associated with physical frailty and increased risk of morbidity (chronic diseases), in…”
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Diabetes mellitus and risks of cognitive impairment and dementia: A systematic review and meta-analysis of 144 prospective studies by Xue, Mei, Xu, Wei, Ou, Ya-Nan, Cao, Xi-Peng, Tan, Meng-Shan, Tan, Lan, Yu, Jin-Tai

“…Uncertainties persist about the associations of diabetes with risk of cognitive impairment and dementia. We aimed to illuminate these associations from various…”
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Impact of Intermittent Fasting on Health and Disease Processes by Mattson, Mark P, Longo, Valter D, Harvie, Michelle

“…Abstract Humans in modern societies typically consume food at least three times daily, while laboratory animals are fed ad libitum. Overconsumption of food…”
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Multimorbidity and quality of life: Systematic literature review and meta-analysis by Makovski, Tatjana T, Schmitz, Susanne, Zeegers, Maurice P, Stranges, Saverio, van den Akker, Marjan

“…Multimorbidity is typically defined as the co-existence of two or more chronic diseases within an individual. Its prevalence is highest among the elderly, with…”
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Sarcopenia – Molecular mechanisms and open questions by Wiedmer, Petra, Jung, Tobias, Castro, José Pedro, Pomatto, Laura C.D., Sun, Patrick Y., Davies, Kelvin J.A., Grune, Tilman

“…•Sarcopenia, a muscle-wasting syndrome during normal aging, is mainly characterized by loss of muscle strength and mass.•Several molecular mechanisms have been…”
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Oxidative stress and regulated cell death in Parkinson’s disease by Dionísio, P.A., Amaral, J.D., Rodrigues, C.M.P.

“…•Physiological mechanisms involved in susceptibility of dopaminergic neurons to oxidative stress.•Effects of the PD-causing neurotoxin MPTP on mitochondrial…”
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Relationship between depression and frailty in older adults: A systematic review and meta-analysis by Soysal, Pinar, Veronese, Nicola, Thompson, Trevor, Kahl, Kai G, Fernandes, Brisa S, Prina, A. Matthew, Solmi, Marco, Schofield, Patricia, Koyanagi, Ai, Tseng, Ping-Tao, Lin, Pao-Yao, Chu, Che-Sheng, Cosco, Theodore D, Cesari, Matteo, Carvalho, Andre F, Stubbs, Brendon

“…Highlights • Depression and frailty are two common and pervasive conditions in older age. • We conducted the first meta-analysis exploring the relationship…”
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Synaptic basis of Alzheimer’s disease: Focus on synaptic amyloid beta, P-tau and mitochondria by John, Albin, Reddy, P. Hemachandra

“…•Alzheimer’s disease (AD) is a progressive and synaptic failure disease.•Synaptic pathology and mitochondrial oxidative damage are early events in Alzheimer’s…”
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Inflammation And Frailty In The Elderly: A Systematic Review And Meta-analysis by Soysal, Pinar, MD, Stubbs, Brendon, Ph.D, Lucato, Paola, MD, Luchini, Claudio, MD, Solmi, Marco, MD, Peluso, Roberto, MD, Sergi, Giuseppe, MD, Isik, Ahmet Turan, MD, Manzato, Enzo, MD, Maggi, Stefania, MD, Maggio, Marcello, MD, Prina, A. Matthew, Ph.D, Cosco, Theodore D., PhD, Wu, Yu-Tzu, PhD, Veronese, Nicola, MD

“…Highlights • The pathogenesis of frailty is poorly understood. • Frailty and pre-frailty are associated with higher CRP and IL 6. • Inflammatory parameters are…”
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Stress and telomere shortening: Insights from cellular mechanisms by Lin, Jue, Epel, Elissa

“…Short telomeres confer risk of degenerative diseases. Chronic psychological stress can lead to disease through many pathways, and research from in vitro…”
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Defective mitophagy in Alzheimer’s disease by Pradeepkiran, Jangampalli Adi, Reddy, P. Hemachandra

“…•Healthy mitochondria are essential for functional bioenergetics, cellular functions and balanced homeostasis.•Mitophagy is a cellular process whereby damaged…”
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Inflammation and cerebral small vessel disease: A systematic review by Low, Audrey, Mak, Elijah, Rowe, James B, Markus, Hugh S, O'Brien, John T

“…Inflammation is increasingly implicated as a risk factor for dementia, stroke, and small vessel disease (SVD). However, the underlying mechanisms and causative…”
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