Spasmolytic effects of aqueous extract of mixture from Aframomumum melegueta (K Schum) - Citrus aurantifolia (Christm and Panzer) on isolated trachea from rat

Spasmolytic effects of aqueous extract of mixture from Aframomumum melegueta (K Schum) - Citrus aurantifolia (Christm and Panzer) on isolated trachea from rat

The spasmolytic properties of the aqueous extract of Aframomum melegueta (K Schum) and Citrus aurantifolia (Christm and Panzer) (AMCA) mixture were tested on isolated rat trachea. Inhibition of the contraction was observed the in presence of the AMCA (EC 50 = 1.80 ± 0.48 mg/mL) after a pre contracti...

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Bibliographic Details
Published in:African journal of traditional, complementary, and alternative medicines Vol. 9; no. 2; pp. 228 - 233
Main Authors: Ahounou, Judith F, Ouedraogo, Geoffroy G, Gbenou, Joachim D, Ouedraogo, Sylvin, Agbodjogbe, Wilfrid Kdd, Dansou, Pierre H, Moudachirou, Mansourou
Format: Journal Article
Language:English
Published: Nigeria African Networks on Ethnomedicines 01-01-2012
Subjects:
Acetylcholine
Adrenergic beta-Antagonists - pharmacology
Animals
Citrus
Male
Muscle Contraction - drug effects
Muscle, Smooth - drug effects
Parasympatholytics - pharmacology
Plant Extracts - pharmacology
Potassium Chloride
Propranolol
Rats
Rats, Wistar
Research Papers
Trachea - drug effects
Zingiberaceae
Aframomum melegueta
bronchodilatory
extract
Rat trachea
spasmolytic
Citrus aurantifolia
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Summary:The spasmolytic properties of the aqueous extract of Aframomum melegueta (K Schum) and Citrus aurantifolia (Christm and Panzer) (AMCA) mixture were tested on isolated rat trachea. Inhibition of the contraction was observed the in presence of the AMCA (EC 50 = 1.80 ± 0.48 mg/mL) after a pre contraction of the trachea by acetylcholine (10⁻⁵ M). With propranolol (10⁻⁶ M), the spasmolytic activity of the mixture was inhibited and the concentration-response curve shifted to the right. The EC50 value was then 2.60 ± 0.41 mg/mL. AMCA also inhibited contraction induced by KCl (4.10⁻² M) with EC50 value = 1.86 ± 0.65 mg/mL. These results clearly show the relaxing effect of the aqueous extract on the isolated rat trachea. This effect involved some β-adrenergic receptor inhibition.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0189-6016
2505-0044
0189-6016
DOI:10.4314/ajtcam.v9i2.7