Non-communicable disease co-morbidity and associated factors in tuberculosis patients: A cross-sectional study in Gabon

There are only limited data from resource-limited settings available on the prevalence of non-communicable diseases and associated risk factors of tuberculosis patients. This study investigated non-communicable disease co-morbidity in tuberculosis patients from Moyen Ogooué Province, Gabon. All pati...

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Published in:	EClinicalMedicine Vol. 45; p. 101316
Main Authors:	Adegbite, BR, Edoa, JR, Agbo Achimi Abdul, JBP, Epola, M, Mevyann, C, Dejon-Agobé, JC, Zinsou, JF, Honkpehedji, YJ, Mpagama, SG, Alabi, AS, Kremsner, PG, Klipstein-Grobusch, K, Adegnika, AA, Grobusch, MP
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-03-2022 Elsevier
Subjects:	Co-morbidity Diabetes Hypertension Non-communicable diseases Obesity Tuberculosis Hypertension Obesity Tuberculosis Non-communicable diseases Diabetes Co-morbidity
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Summary:	There are only limited data from resource-limited settings available on the prevalence of non-communicable diseases and associated risk factors of tuberculosis patients. This study investigated non-communicable disease co-morbidity in tuberculosis patients from Moyen Ogooué Province, Gabon. All patients aged 18 years or older consulting for tuberculosis (TB) symptoms in Gabon's Moyen Ogooué province and neighbouring provinces from November 2018 to November 2020 were screened for diabetes mellitus, hypertension, and risk factors thereof (obesity, dyslipidaemia, smoking and alcohol consumption). Logistic regression was performed to identify factors associated with TB-diabetes and TB-hypertension co-morbidities. Of 583 patients included, 227 (39%) were diagnosed with tuberculosis. In tuberculosis-confirmed patients, the prevalences of hypertension and diabetes were 16·3% and 12·8%, respectively. The prevalence of diabetes was twice as high in tuberculosis patients compared to non-tuberculosis patients. Factors independently associated with hypertension-tuberculosis co-morbidity were age >55 years (aOR=8·5, 95% CI 2·43, 32·6), age 45–54 years (aOR=4.9, 95%CI 1.3–19.8), and moderate alcohol consumption (aOR=2·4; 95% CI 1·02- 5·9), respectively. For diabetes-tuberculosis co-morbidity, age >55 years was positively (aOR=9·13; 95% CI 2·4–39·15), and moderate alcohol consumption inversely associated (aOR=0·26, 95% CI 0·08- 0·73). One-hundred-and-four (46%) of the tuberculosis patients had at least either dyslipidaemia, hypertension, diabetes, or obesity with a majority of newly-diagnosed hypertension and diabetes. Integration of screening of non-communicable diseases and their risk factors during TB assessment for early diagnosis, treatment initiation and chronic care management for better health outcomes should be implemented in all tuberculosis healthcare facilities. This study was supported by WHO AFRO/TDR/EDCTP (2019/893,805) and Deutsches Zentrum für Infektiologie (DZIF/ TTU 02.812).
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2589-5370 2589-5370
DOI:	10.1016/j.eclinm.2022.101316