Toxicological screening of Daouri, a polyherbal formulation used in children in the Central Region of Togo

Toxicological screening of Daouri, a polyherbal formulation used in children in the Central Region of Togo

Daouri, a combination of several plants, is an old African Traditional Medicine based on ancestral knowledge transmitted from generation to generation and is used by the Kotokoli Community in Togo. The combination of several plants may potentiate or attenuate the toxicity of individual plants. The p...

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Bibliographic Details
Published in:Journal of ethnopharmacology Vol. 164; pp. 30 - 34
Main Authors: Edorh, Mawutodji S., Agbere, Sadikou, Osei-Safo, Dorcas, Adam, Zakilatou, Agbonon, Amegnona, Karou, Damintoti S., Agbere, Rahamane A., Gbeassor, Messanvi
Format: Journal Article
Language:English
Published: Ireland Elsevier Ireland Ltd 22-04-2015
Subjects:
Animals
Child
Children health
Female
Humans
Magnoliopsida - toxicity
Male
Medicine, African Traditional
Plant Preparations - analysis
Plant Preparations - toxicity
Plants, Medicinal - toxicity
Polyherbal
Rats, Wistar
Togo
Toxicity
Traditional medicine
Children health
Polyherbal
Traditional medicine
Toxicity
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Summary:Daouri, a combination of several plants, is an old African Traditional Medicine based on ancestral knowledge transmitted from generation to generation and is used by the Kotokoli Community in Togo. The combination of several plants may potentiate or attenuate the toxicity of individual plants. The present investigation aims to study the composition and potential toxicity of Daouri used in children in the Kotokoli community. Surveys were performed using a semi-structured questionnaire to determine the composition of Daouri. On the basis of these data collected, Standard Daouri was formulated, and its aqueous extract was orally administered at 300, 600 and 1200mg/kg to rats for 28 days. On the 29th day, the rats were sacrificed and their serum were analysed to evaluate hepatic and renal toxicities. Four categories of Daouri were collected. The plant combinations used in each Daouri formulation varied according to the pathological conditions, including the age of the children and the availability of each plant. The most plants cited in the four Daouri were Khaya senegalensis (Desv.) A. Juss, Odina acida (A. Rich.) Oliv.,Lophira lanceolata Tiegh, Paullinia pinnata L. and Pteleopsis suberosa Engl. & Diels. Although there was an increase in the alkaline phosphatase concentration, different doses of the aqueous extract of Standard Daouri were not toxic after 28 days of administration. In addition, the concentrations of alanine transaminase, creatinine and urea were not different between the Daouri-treated and control groups. Daouri is plant combination used in children in the Kotokoli community as a part of African Traditional Medicine. Standard Daouri is not toxic in rats. [Display omitted]
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2015.01.045