Search Results - "Agazie, Y M"

Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast cancer cells by Zhou, X-D, Agazie, Y M

“…The Src homology phosphotyrosyl phosphatase 2 (SHP2) is an essential transducer of mitogenic and cell survival signaling in the epidermal growth factor…”
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SHP2 is up-regulated in breast cancer cells and in infiltrating ductal carcinoma of the breast, implying its involvement in breast oncogenesis by Zhou, X, Coad, J, Ducatman, B, Agazie, Y M

“…Aims:  To determine whether Src homology phosphotyrosyl phosphatase 2 (SHP2) is up‐regulated in breast cancer and, if so, to determine whether its…”
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Modulation of α-catenin Tyr phosphorylation by SHP2 positively effects cell transformation induced by the constitutively active FGFR3 by BURKS, J, AGAZIE, Y. M

“…The Src homology 2 phosphotyrosyl phosphatase (SHP2) is a nonreceptor-type phosphatase that acts as a positive transducer of receptor Tyr kinase (RTK)…”
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HER2 stabilizes EGFR and itself by altering autophosphorylation patterns in a manner that overcomes regulatory mechanisms and promotes proliferative and transformation signaling by Hartman, Z, Zhao, H, Agazie, Y M

“…One of the causes of breast cancer is overexpression of the human epidermal growth factor receptor 2 (HER2). Enhanced receptor autophosphorylation and…”
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Regulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer by Farrugia, M K, Sharma, S B, Lin, C-C, McLaughlin, S L, Vanderbilt, D B, Ammer, A G, Salkeni, M A, Stoilov, P, Agazie, Y M, Creighton, C J, Ruppert, J M

“…The Kruppel-like transcription factors (KLFs) 4 and 5 (KLF4/5) are coexpressed in mouse embryonic stem cells, where they function redundantly to maintain…”
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Development of an Efficient “Substrate-trapping” Mutant of Src Homology Phosphotyrosine Phosphatase 2 and Identification of the Epidermal Growth Factor Receptor, Gab1, and Three Other Proteins as Target Substrates by Agazie, Yehenew M., Hayman, Michael J.

“…Src homology containing phosphotyrosine phosphatase 2 (SHP2) is a positive effector of growth factor, cytokine, and integrin signaling. However, neither its…”
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The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3 by AGAZIE, Yehenew M, MOVILLA, Nieves, ISCHENKO, Irene, HAYMAN, Michael J

“…Receptor tyrosine kinases (RTKs) such as the fibroblast growth factor receptor (FGFR) and the epidermal growth factor receptor are overexpressed in a variety…”
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ATP-stimulated smooth muscle cell proliferation requires independent ERK and PI3K signaling pathways by Wilden, P A, Agazie, Y M, Kaufman, R, Halenda, S P

“…Vascular smooth muscle cells respond to the purinergic agonist ATP by increasing intracellular calcium concentration and increasing the rate of cell…”
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Triplex DNA in the nucleus: direct binding of triplex-specific antibodies and their effect on transcription, replication and cell growth by Agazie, Y M, Burkholder, G D, Lee, J S

“…Jel 318 and Jel 466 are triplex-specific monoclonal antibodies which previously have been shown to bind to cell nuclei and chromosomes by immunofluorescence…”
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Characterization of a new monoclonal antibody to triplex DNA and immunofluorescent staining of mammalian chromosomes by MEKONNEN AGAZIE, Y, LEE, J. S, BURKHOLDER, G. D

“…A monoclonal antibody, Jel 466, was prepared from mice immunized with poly[d(Tm5C)].poly[d(GA)]. The binding of Jel 466 to nucleic acids was characterized by…”
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Molecular mechanisms of ATP and insulin synergistic stimulation of coronary artery smooth muscle growth by Agazie, Y M, Bagot, J C, Trickey, E, Halenda, S P, Wilden, P A

“…Coronary artery disease (CAD) is the major cause of death in diabetics. Abnormal proliferation of coronary artery smooth muscle cells (CASMC) leads to intimal…”
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Modulation of -catenin Tyr phosphorylation by SHP2 positively effects cell transformation induced by the constitutively active FGFR3 by Burks, J, Agazie, Y M

“…The Src homology 2 phosphotyrosyl phosphatase (SHP2) is a nonreceptor-type phosphatase that acts as a positive transducer of receptor Tyr kinase (RTK)…”
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Molecular Mechanism for a Role of SHP2 in Epidermal Growth Factor Receptor Signaling by Agazie, Yehenew M., Hayman, Michael J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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P3-01-15: The Role of Src Homology Phosphotyrosyl Phosphatase-2 in Basal-Type/Triple-Negative Breast Cancer – Implications for Targeted Therapy by Agazie, YM, Matalka, F, Hartman, ZR

“…Abstract Background: Of all breast cancer subtypes, the basal-type/triple-negative breast cancer (BTBC) has the worst clinical outcome. The major reasons are…”
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P2-02-05: Molecular Mechanism for Src Homology Phosphotyrosyl Phosphatase 2 Regulation of Cell Motility and Migration by Hartman, ZR, Agazie, YM

“…Abstract Background: The Src homology phosphotyrosyl phosphatase 2 (SHP2) acts as a transducer of mitogenic and cell survival signaling downstream of receptor…”
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Specificity of monoclonal antibodies produced against phosphorothioate and ribo modified DNAs by Latimer, Laura J.P., Agazie, Yehenew M., Braun, Ralph P., Hampel, Ken J., Lee, Jeremy S.

“…A large number of phosphorothioate DNAs and mixed ribo/deoxyribo duplexes were prepared and their immunogenicity was studied in mice. Only those polymers which…”
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Mutation of Thr466 in SHP2 abolishes its phosphatase activity, but provides a new substrate-trapping mutant by Merritt, Rebecca, Hayman, Michael J., Agazie, Yehenew M.

“…Most classical phosphotyrosyl phosphatases (PTPs), including the Src homology phosphotyrosyl phosphatase 2 (SHP2) possess a Thr or a Ser residue immediately…”
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