Search Results - "Agarwal, Hitesh K"

Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity by Fowler, Benjamin J., Gelfand, Bradley D., Kim, Younghee, Kerur, Nagaraj, Tarallo, Valeria, Hirano, Yoshio, Amarnath, Shoba, Fowler, Daniel H., Radwan, Marta, Young, Mark T., Pittman, Keir, Kubes, Paul, Agarwal, Hitesh K., Parang, Keykavous, Hinton, David R., Bastos-Carvalho, Ana, Li, Shengjian, Yasuma, Tetsuhiro, Mizutani, Takeshi, Yasuma, Reo, Wright, Charles, Ambati, Jayakrishna

“…Nucleoside reverse transcriptase inhibitors (NRTIs) are mainstay therapeutics for HIV that block retrovirus replication. Alu (an endogenous retroelement that…”
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Ca2+-dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapses by Zhai, Shenyu, Otsuka, Shintaro, Xu, Jian, Clarke, Vernon R.J., Tkatch, Tatiana, Wokosin, David, Xie, Zhong, Tanimura, Asami, Agarwal, Hitesh K., Ellis-Davies, Graham C.R., Contractor, Anis, Surmeier, D. James

“…Long-term synaptic plasticity at glutamatergic synapses on striatal spiny projection neurons (SPNs) is central to learning goal-directed behaviors and habits…”
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Synthesis and Biological Evaluation of 5'- O -Fatty Acyl Ester Derivatives of 3'-Fluoro-2',3'-dideoxythymidine as Potential Anti-HIV Microbicides by Agarwal, Hitesh K, Chhikara, Bhupender S, Ye, Guofeng, Bhavaraju, Sitaram, Dixit, Ajay, Kumar, Anil, Doncel, Gustavo F, Parang, Keykavous

“…A number of 5′-O-fatty acyl derivatives of 3′-fluoro-2′,3′-dideoxythymidine (FLT, 1) were synthesized. These conjugates were evaluated for their potential as…”
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Synthesis and evaluation of thymidine kinase 1-targeting carboranyl pyrimidine nucleoside analogs for boron neutron capture therapy of cancer by Agarwal, Hitesh K., Khalil, Ahmed, Ishita, Keisuke, Yang, Weilian, Nakkula, Robin J., Wu, Lai-Chu, Ali, Tehane, Tiwari, Rohit, Byun, Youngjoo, Barth, Rolf F., Tjarks, Werner

“…A library of sixteen 2nd generation amino- and amido-substituted carboranyl pyrimidine nucleoside analogs, designed as substrates and inhibitors of thymidine…”
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Synthesis, chemical and enzymatic hydrolysis, and aqueous solubility of amino acid ester prodrugs of 3-carboranyl thymidine analogs for boron neutron capture therapy of brain tumors by Hasabelnaby, Sherifa, Goudah, Ayman, Agarwal, Hitesh K., Abd alla, Mosaad S.M., Tjarks, Werner

“…Various water-soluble l-valine-, l-glutamate-, and glycine ester prodrugs of two 3-Carboranyl Thymidine Analogs (3-CTAs), designated N5 and N5-2OH, were…”
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Cellular influx, efflux, and anabolism of 3-carboranyl thymidine analogs: potential boron delivery agents for neutron capture therapy by Sjuvarsson, Elena, Damaraju, Vijaya L, Mowles, Delores, Sawyer, Michael B, Tiwari, Rohit, Agarwal, Hitesh K, Khalil, Ahmed, Hasabelnaby, Sherifa, Goudah, Ayman, Nakkula, Robin J, Barth, Rolf F, Cass, Carol E, Eriksson, Staffan, Tjarks, Werner

“…3-[5-{2-(2,3-Dihydroxyprop-1-yl)-o-carboran-1-yl}pentan-1-yl]thymidine (N5-2OH) is a first generation 3-carboranyl thymidine analog (3CTA) that has been…”
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Synthesis, Analysis, in Vitro Characterization, and in Vivo Disposition of a Lamivudine–Dextran Conjugate for Selective Antiviral Delivery to the Liver by Chimalakonda, Krishna C, Agarwal, Hitesh K, Kumar, Anil, Parang, Keykavous, Mehvar, Reza

“…A liver-selective prodrug (3TCSD) of the antiviral drug lamivudine (3TC) was developed and characterized. 3TC was coupled to dextran (∼25 kDa) using a…”
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Synthesis and anti-HIV activities of suramin conjugates of 3'-fluoro- 2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine by Agarwal, Hitesh K, Doncel, Gustavo F, Parang, Keykavous

“…Conjugates between suramin, a polyanionic naphthalene sulfonate derivative, and nucleoside reverse transcriptase inhibitors (NRTIs),…”
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The yin and yang of intracellular delivery of amphipathic optical probes using n -butyl charge masking by Agarwal, Hitesh K, Janicek, Radoslav, Zhao, Jun, Sambath, Karthik, Egger, Marcel, Niggli, Ernst, Ellis-Davies, Graham C R

“…Monitoring and manipulation of ionized intracellular calcium concentrations within intact, living cells using optical probes with organic chromophores is a…”
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Calcium Uncaging with Visible Light by Agarwal, Hitesh K, Janicek, Radoslav, Chi, San-Hui, Perry, Joseph W, Niggli, Ernst, Ellis-Davies, Graham C. R

“…We have designed a nitroaromatic photochemical protecting group that absorbs visible light in the violet-blue range. The chromophore is a dinitro derivative of…”
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Caged compounds for multichromic optical interrogation of neural systems by Amatrudo, Joseph M., Olson, Jeremy P., Agarwal, Hitesh K., Ellis-Davies, Graham C. R.

“…Caged compounds are widely used by neurophysiologists to study many aspects of cellular signaling in glia and neurons. Biologically inert before irradiation,…”
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Synthesis and anti-HIV activities of unsymmetrical long chain dicarboxylate esters of dinucleoside reverse transcriptase inhibitors by Agarwal, Hitesh K., Chhikara, Bhupender S., Doncel, Gustavo F., Parang, Keykavous

“…The synthesis of unsymmetrical long chain dicarboxylate esters of dinucleoside reverse transcriptase inhibitors and their anti-HIV activities are reported…”
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Synthesis and Biological Evaluation of Fatty Acyl Ester Derivatives of (−)-2′,3′-Dideoxy-3′-thiacytidine by Agarwal, Hitesh K, Chhikara, Bhupender S, Hanley, Michael J, Ye, Guofeng, Doncel, Gustavo F, Parang, Keykavous

“…A number of fatty acyl derivatives of (−)-2′,3′-dideoxy-3′-thiacytidine (lamivudine, 3TC, 1) were synthesized and evaluated for their anti-HIV activity. The…”
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Emtricitabine Prodrugs with Improved Anti-HIV Activity and Cellular Uptake by Agarwal, Hitesh K, Chhikara, Bhupender S, Bhavaraju, Sitaram, Mandal, Dindyal, Doncel, Gustavo F, Parang, Keykavous

“…Three fatty acyl conjugates of (−)-2′,3′-dideoxy-5-fluoro-3′-thiacytidine (FTC, emtricitabine) were synthesized and evaluated against HIV-1 cell-free and…”
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Intracellular Uncaging of cGMP with Blue Light by Agarwal, Hitesh K, Zhai, Shenyu, Surmeier, D. James, Ellis-Davies, Graham C. R

“…We have made a new caged cGMP that is photolyzed with blue light. Using our recently developed derivative of 7-diethylaminocourmarin (DEAC) called DEAC450, we…”
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Synthesis of N3-substituted carboranyl thymidine bioconjugates and their evaluation as substrates of recombinant human thymidine kinase 1 by Agarwal, Hitesh K., McElroy, Craig A., Sjuvarsson, Elena, Eriksson, Staffan, Darby, Michael V., Tjarks, Werner

“…Four different libraries of overall twenty three N3-substituted thymidine (dThd) analogues, including eleven 3-carboranyl thymidine analogues (3CTAs), were…”
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Synthesis of closo-1,7-carboranyl alkyl amines by Agarwal, Hitesh K., Buszek, Benjamin, Ricks, Kevin G., Tjarks, Werner

“…Of the three closo-carborane isomers (C 2B 10H 12), closo-1,2-carborane has been used most widely in the synthesis of carboranyl amines. However,…”
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Synthesis and Anti-HIV Activities of Glutamate and Peptide Conjugates of Nucleoside Reverse Transcriptase Inhibitors by Agarwal, Hitesh K, Chhikara, Bhupender S, Quiterio, Megrose, Doncel, Gustavo F, Parang, Keykavous

“…Mono-, di-, and trinucleoside conjugates of glutamate or peptide scaffolds containing nucleoside reverse transcriptase inhibitors were synthesized. Among…”
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Synthesis, antiviral and contraceptive activities of nucleoside–sodium cellulose sulfate acetate and succinate conjugates by Agarwal, Hitesh K., Kumar, Anil, Doncel, Gustavo F., Parang, Keykavous

“…The synthesis and anti-HIV activities of two classes of conjugates between sodium cellulose sulfate succinate and sodium cellulose sulfate acetate as HIV-entry…”
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Synthesis and biological evaluation of fatty acyl ester derivatives of 2′,3′-didehydro-2′,3′-dideoxythymidine by Agarwal, Hitesh K., Loethan, Kelly, Mandal, Deendayal, Doncel, Gustavo F., Parang, Keykavous

“…The synthesis, anti-HIV activities against cell-free and cell-associated virus, cellular cytotoxicity, and cellular uptake studies of 5′- O-fatty acyl…”
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