Search Results - "Agarwal, Chapla"

Anticancer and cancer chemopreventive potential of grape seed extract and other grape-based products by Kaur, Manjinder, Agarwal, Chapla, Agarwal, Rajesh

“…With emerging trends in the incidence of cancer of various organ sites, additional approaches are needed to control human malignancies. Intervention or…”
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Gallic Acid, an Active Constituent of Grape Seed Extract, Exhibits Anti-proliferative, Pro-apoptotic and Anti-tumorigenic Effects Against Prostate Carcinoma Xenograft Growth in Nude Mice by Kaur, Manjinder, Velmurugan, Balaiya, Rajamanickam, Subapriya, Agarwal, Rajesh, Agarwal, Chapla

“…Purpose Gallic acid, a natural agent present in a wide-range of fruits and vegetables, has been of potential interest as an anti-cancer agent; herein, we…”
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Metformin suppresses growth of human head and neck squamous cell carcinoma via global inhibition of protein translation by Sikka, Arron, Kaur, Manjinder, Agarwal, Chapla, Deep, Gagan, Agarwal, Rajesh

“…Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cancer in the world; the main risk factors are alcohol and tobacco use. Advancements in…”
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Pathophysiology and inflammatory biomarkers of sulfur mustard-induced corneal injury in rabbits by Goswami, Dinesh G, Mishra, Neha, Kant, Rama, Agarwal, Chapla, Croutch, Claire R, Enzenauer, Robert W, Petrash, Mark J, Tewari-Singh, Neera, Agarwal, Rajesh

“…Sulfur mustard (SM) is a cytotoxic, vesicating, chemical warfare agent, first used in 1917; corneas are particularly vulnerable to SM exposure. They may…”
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Silibinin Is a Potent Sensitizer of UVA Radiation-induced Oxidative Stress and Apoptosis in Human Keratinocyte HaCaT Cells by Narayanapillai, Sreekanth, Agarwal, Chapla, Tilley, Cynthia, Agarwal, Rajesh

“…UVA radiation (315–400 nm), which constitutes ca 95% of the UV irradiation in natural sunlight reaching earth surface, is a major environmental risk factor…”
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Hypoxia induces triglycerides accumulation in prostate cancer cells and extracellular vesicles supporting growth and invasiveness following reoxygenation by Schlaepfer, Isabel R, Nambiar, Dhanya K, Ramteke, Anand, Kumar, Rahul, Dhar, Deepanshi, Agarwal, Chapla, Bergman, Bryan, Graner, Michael, Maroni, Paul, Singh, Rana P, Agarwal, Rajesh, Deep, Gagan

“…Hypoxia is an independent prognostic indicator of poor outcome in several malignancies. However, precise mechanism through which hypoxia promotes disease…”
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Gallic acid causes inactivating phosphorylation of cdc25A/cdc25C-cdc2 via ATM-Chk2 activation, leading to cell cycle arrest, and induces apoptosis in human prostate carcinoma DU145 cells by Agarwal, Chapla, Tyagi, Alpna, Agarwal, Rajesh

“…We recently reported that gallic acid is a major active agent responsible for grape seed extract activity in DU145 human prostate carcinoma cells. The present…”
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Anti-cancer efficacy of silybin derivatives -- a structure-activity relationship by Agarwal, Chapla, Wadhwa, Ritambhara, Deep, Gagan, Biedermann, David, Gažák, Radek, Křen, Vladimír, Agarwal, Rajesh

“…Silybin or silibinin, a flavonolignan isolated from Milk thistle seeds, is one of the popular dietary supplements and has been extensively studied for its…”
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Grape Seed Extract Inhibits In vitro and In vivo Growth of Human Colorectal Carcinoma Cells by KAUR, Manjinder, SINGH, Rana P, GU, Mallikarjuna, AGARWAL, Rajesh, AGARWAL, Chapla

“…Purpose: Accumulating evidences suggest the beneficial effects of fruit-and-vegetable consumption in lowering the risk of various cancers, including colorectal…”
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Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice by GU, Mallikarjuna, SINGH, Rana P, DHANALAKSHMI, Sivanandhan, AGARWAL, Chapla, AGARWAL, Rajesh

“…Sunscreens partially filter UVB and, therefore, could partially prevent skin cancer; however, efficient approaches are desired to effectively prevent…”
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Silibinin attenuates sulfur mustard analog-induced skin injury by targeting multiple pathways connecting oxidative stress and inflammation by Tewari-Singh, Neera, Jain, Anil K, Inturi, Swetha, Agarwal, Chapla, White, Carl W, Agarwal, Rajesh

“…Chemical warfare agent sulfur mustard (HD) inflicts delayed blistering and incapacitating skin injuries. To identify effective countermeasures against…”
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Asiatic acid inhibits pro-angiogenic effects of VEGF and human gliomas in endothelial cell culture models by Kavitha, Chandagirikoppal V, Agarwal, Chapla, Agarwal, Rajesh, Deep, Gagan

“…Malignant gliomas are one of the most devastating and incurable tumors. Sustained excessive angiogenesis by glioma cells is the major reason for their…”
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Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules by Ramteke, Anand, Ting, Harold, Agarwal, Chapla, Mateen, Samiha, Somasagara, Ranganathan, Hussain, Anowar, Graner, Michael, Frederick, Barbara, Agarwal, Rajesh, Deep, Gagan

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Chemopreventive effects of oral gallic acid feeding on tumor growth and progression in TRAMP mice by Raina, Komal, Rajamanickam, Subapriya, Deep, Gagan, Singh, Meenakshi, Agarwal, Rajesh, Agarwal, Chapla

“…Our recent studies have identified gallic acid as one of the major constituents of grape seed extract showing strong in vitro anticancer efficacy against human…”
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Inositol hexaphosphate suppresses growth and induces apoptosis in prostate carcinoma cells in culture and nude mouse xenograft: PI3K-Akt pathway as potential target by Gu, Mallikarjuna, Roy, Srirupa, Raina, Komal, Agarwal, Chapla, Agarwal, Rajesh

“…Constitutive activation of phosphoinositide 3-kinase (PI3K)-Akt pathway transmits growth-regulatory signals that play a central role in promoting survival,…”
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Silibinin Suppresses Growth of Human Colorectal Carcinoma SW480 Cells in Culture and Xenograft through Down-regulation of β-Catenin-Dependent Signaling by Kaur, Manjinder, Velmurugan, Balaiya, Tyagi, Alpna, Agarwal, Chapla, Singh, Rana P., Agarwal, Rajesh

“…Mutations in APC/β-catenin resulting in an aberrant activation of Wnt/β-catenin pathway are common in colorectal cancer (CRC), suggesting that targeting the…”
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Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells by Veluri, Ravikanth, Singh, Rana P., Liu, Zhengjie, Thompson, John A., Agarwal, Rajesh, Agarwal, Chapla

“…The anti-cancer efficacy of grape seed extract (GSE) against prostate cancer (PCA) via its anti-proliferative, pro-apoptotic and anti-angiogenic activities in…”
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Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells by AGARWAL, Chapla, SINGH, Rana P, DHANALAKSHMI, Sivanandhan, TYAGI, Anil K, TECKLENBURG, Marianne, SCLAFANI, Robert A, AGARWAL, Rajesh

“…Silymarin, a defined mixture of natural flavonoid, has recently been shown to have potent cancer chemopreventive efficacy against colon carcinogenesis in rat…”
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Silibinin inhibits human nonsmall cell lung cancer cell growth through cell-cycle arrest by modulating expression and function of key cell-cycle regulators by Mateen, Samiha, Tyagi, Alpna, Agarwal, Chapla, Singh, Rana P., Agarwal, Rajesh

“…Recent studies show that silibinin possesses a strong antineoplastic potential against many cancers; however, its efficacy and underlying molecular mechanisms…”
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7- O -tyrosyl Silybin Derivatives as a Novel Set of Anti-Prostate Cancer Compounds by Romanucci, Valeria, Pagano, Rita, Kandhari, Kushal, Zarrelli, Armando, Petrone, Maria, Agarwal, Chapla, Agarwal, Rajesh, Di Fabio, Giovanni

“…Silybin is a natural compound extensively studied for its hepatoprotective, neuroprotective and anticancer properties. Envisioning the enhancement of silybin…”
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