Search Results - "Agapova, L S"

Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway by Kravchenko, J.E, Ilyinskaya, G.V, Komarov, P.G, Agapova, L.S, Kochetkov, D.V, Strom, E, Frolova, E.I, Kovriga, I, Gudkov, A.V, Feinstein, E, Chumakov, P.M

“…Identification of unique features of cancer cells is important for defining specific and efficient therapeutic targets. Mutant p53 is present in nearly half of…”
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p53 hot-spot mutants increase tumor vascularization via ROS-mediated activation of the HIF1/VEGF-A pathway by Khromova, N.V, Kopnin, P.B, Stepanova, E.V, Agapova, L.S, Kopnin, B.P

“…Abstract The function of p53 tumor suppressor is often altered in various human tumors predominantly through missense-mutations resulting in accumulation of…”
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Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 3. Inhibitory effect of SkQ1 on tumor development from p53-deficient cells by Agapova, L. S, Chernyak, B. V, Domnina, L. V, Dugina, V. B, Efimenko, A. Yu, Fetisova, E. K, Ivanova, O. Yu, Kalinina, N. I, Khromova, N. V, Kopnin, B. P, Kopnin, P. B, Korotetskaya, M. V, Lichinitser, M. R, Lukashev, A. L, Pletjushkina, O. Yu, Popova, E. N, Skulachev, M. V, Shagieva, G. S, Stepanova, E. V, Titova, E. V, Tkachuk, V. A, Vasiliev, J. M, Skulachev, V. P

“…It was proposed that increased level of mitochondrial reactive oxygen species (ROS), mediating execution of the aging program of an organism, could also be…”
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P53-dependent effects of RAS oncogene on chromosome stability and cell cycle checkpoints by Agapova, L S, Ivanov, A V, Sablina, A A, Kopnin, P B, Sokova, O I, Chumakov, P M, Kopnin, B P

“…Mutations activating the function of ras proto-oncogenes are often observed in human tumors. Their oncogenic potential is mainly due to permanent stimulation…”
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Retroviral reporter systems for assessing the activity of stress-inducible signal transduction pathways controlled by the p53, HIF-1, and HSF-1 transcription factors by Razorenova, O V, Agapova, L S, Budanov, A V, Ivanov, A V, Strunina, S M, Chumakov, P M

“…The tumor suppressor p53, hypoxia-inducible factor 1 (HIF-1), and heat-shock factor 1 (HSF-1) are the key transcription factors involved in the stress response…”
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Expression of the p53 Gene and Activation of p53-Dependent Transcription in Melanoma Cell Lines by Razorenova, O V, Agapova, L S, Chumakov, P M

“…Malignant melanoma has poor prognosis because of its high metastatic potential and resistance to chemotherapy. A possible approach to more effective therapy is…”
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Transcriptional inhibition of human papilloma virus in cervical carcinoma cells reactivates functions of the tumor suppressor p53 by Kochetkov, D V, Il'inskaia, G V, Komarov, P G, Strom, E, Agapova, L S, Ivanov, A V, Budanov, A V, Frolova, E I, Chumakov, P M

“…Inactivation of tumor suppressor p53 accompanies the majority of malignant diseases in humans. Restoration of p53 functions in tumor results in death of cancer…”
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Transcriptional inhibition of the human papilloma virus reactivates tumor suppressor p53 in cervical carcinoma cells by Kochetkov, D V, Ilyinskaya, G V, Komarov, P G, Strom, E, Agapova, L S, Ivanov, A V, Budanov, A V, Frolova, E I, Chumakov, P M

“…Inactivation of tumor suppressor p53 accompanies the majority of human malignancies. Restoration of p53 function causes death of tumor cells and is potentially…”
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Retroviral reporter systems for the assessment of activity of stress-induced signal transduction pathways controlled by p53, HIF-1 and HSF-1 transcription factors by Razorenova, O V, Agapova, L S, Budanov, A V, Ivanov, A V, Strunina, S M, Chumakov, P M

“…Tumor suppressor p53, hypoxia-inducible factor 1 (HIF-1) and heat-shock factor 1 (HSF-1) are involved as the key transcription factors in cellular response to…”
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HLA homozygous stem cell lines derived from human parthenogenetic blastocysts by Revazova, E S, Turovets, N A, Kochetkova, O D, Agapova, L S, Sebastian, J L, Pryzhkova, M V, Smolnikova, V I U, Kuzmichev, L N, Janus, J D

“…Individual HLA homozygous parthenogenetic human stem cell (hpSC-Hhom) lines have the potential for cell-based therapy in a significant number of individuals,…”
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Activation of p53-mediated cell cycle checkpoint in response to micronuclei formation by Sablina, A A, Ilyinskaya, G V, Rubtsova, S N, Agapova, L S, Chumakov, P M, Kopnin, B P

“…Inactivation of p53 tumor-suppressor leads to genetic instability and, in particular, to accumulation of cells with abnormal numbers of chromosomes. In order…”
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Induction of hyperdiploidy and chromosome breaks in LIM1215 cells expressing the exogenous mutant p53 by Agapova, L S, Turovets, N A, Ivanov, A V, Il'inskaia, G V, Chumakov, P M

“…The effect of modifications of p53 expression on the incidence of numerical and structural chromosome aberrations was studied. Infection of LIM1215 cells…”
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p53 DOES NOT CONTROL THE SPINDLE ASSEMBLY CELL CYCLE CHECKPOINT BUT MEDIATES G1 ARREST IN RESPONSE TO DISRUPTION OF MICROTUBULE SYSTEM by Sablina, Anna A, Agapova, Larissa S, Chumakov, Peter M, Kopnin, Boris P

“…p53 plays a critical role as a tumour-suppressor in restricting the proliferation of damaged cells, thus preventing formation of genetically altered cell…”
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The antioxidant function of the p53 tumor suppressor by Chumakov, Peter M, Sablina, Anna A, Budanov, Andrei V, Ilyinskaya, Galina V, Agapova, Larissa S, Kravchenko, Julia E

“…It is widely accepted that the p53 tumor suppressor restricts abnormal cells by induction of growth arrest or by triggering apoptosis. Here we show that, in…”
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Experience in the production and clinical application of the cell-based medicinal product Easytense® for the repair of cartilage defects of the human knee by Zoricheva, A. S., Zvonova, E. A., Agapova, L. S., Lykova, M. S., Markova, O. A., Leonov, V. S.

“…INTRODUCTION . The current cell-based cartilage repair methods, such as autologous chondrocyte transplantation, are not sufficiently effective, and the surgery…”
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Progress in understanding moleculr mechanisms of oncogenesis, and novel methods of tumor growth control by Agapova, L S, Kopnin, B P

“…Malignant tumor develop from cells with distorted signaling pathways controlling proliferation, migration, viability, differentiation, and genome integrity, as…”
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Chromosome changes caused by alterations of p53 expression by Agapova, L S, Ilyinskaya, G V, Turovets, N A, Ivanov, A V, Chumakov, P M, Kopnin, B P

“…It has been proposed that p53 tumor-suppressor plays a key role in maintaining genome integrity in mammalian cells. We analyzed karyotype alterations in human…”
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Effect of inactivating the p33ING1 tumor suppressor on the function of cell cycle "checkpoints" and genome stability by Turovets, N A, Agapova, L S, Kopnin, P B, Tulina, N M, Chumakov, P M, Kopnin, B P

“…Novel candidate tumor suppressor p33ING1 is known to regulate activity of the p53 protein. The effect of p33ING1 inactivation on the functioning of the cell…”
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p53-dependent effects of RAS oncogene on chromosome stability and cell cycle checkpoints by AGAPOVA, L. S, IVANOV, A. V, SABLINA, A. A, KOPNIN, P. B, SOKOVA, O. I, CHUMAKOV, P. M, KOPNIN, B. P

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