Search Results - "Agallou, Maria"

A Poly(Lactic- co -Glycolic) Acid Nanovaccine Based on Chimeric Peptides from Different Leishmania infantum Proteins Induces Dendritic Cells Maturation and Promotes Peptide-Specific IFNγ-Producing CD8 + T Cells Essential for the Protection against Experimental Visceral Leishmaniasis by Athanasiou, Evita, Agallou, Maria, Tastsoglou, Spyros, Kammona, Olga, Hatzigeorgiou, Artemis, Kiparissides, Costas, Karagouni, Evdokia

“…Visceral leishmaniasis, caused by ( .) and protozoan parasites, can provoke overwhelming and protracted epidemics, with high case-fatality rates. An effective…”
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Intramuscular Immunization with a Liposomal Multi-Epitope Chimeric Protein Induces Strong Cellular Immune Responses against Visceral Leishmaniasis by Agallou, Maria, Margaroni, Maritsa, Karagouni, Evdokia

“…Control of the intracellular parasite Leishmania (L.) requires the activation of strong type 1 cellular immune responses. Towards this goal, in the present…”
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Identification of Immunoreactive Leishmania infantum Protein Antigens to Asymptomatic Dog Sera through Combined Immunoproteomics and Bioinformatics Analysis by Agallou, Maria, Athanasiou, Evita, Samiotaki, Martina, Panayotou, George, Karagouni, Evdokia

“…Leishmania infantum is the etiologic agent of zoonotic visceral leishmaniasis (VL) in countries in the Mediterranean basin, where dogs are the domestic…”
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Immunoinformatics Approach to Design a Multi-Epitope Nanovaccine against Leishmania Parasite: Elicitation of Cellular Immune Responses by Margaroni, Maritsa, Agallou, Maria, Tsanaktsidou, Evgenia, Kammona, Olga, Kiparissides, Costas, Karagouni, Evdokia

“…Leishmaniasis is a vector-borne disease caused by an intracellular parasite of the genus with different clinical manifestations that affect millions of people…”
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A Canine-Directed Chimeric Multi-Epitope Vaccine Induced Protective Immune Responses in BALB/c Mice Infected with Leishmania infantum by Agallou, Maria, Margaroni, Maritsa, Kotsakis, Stathis D., Karagouni, Evdokia

“…Leishmaniases are complex vector-borne diseases caused by intracellular parasites of the genus Leishmania. The visceral form of the disease affects both humans…”
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Identification of BALB/c Immune Markers Correlated with a Partial Protection to Leishmania infantum after Vaccination with a Rationally Designed Multi-epitope Cysteine Protease A Peptide-Based Nanovaccine by Agallou, Maria, Margaroni, Maritsa, Athanasiou, Evita, Toubanaki, Dimitra K, Kontonikola, Katerina, Karidi, Konstantina, Kammona, Olga, Kiparissides, Costas, Karagouni, Evdokia

“…Through their increased potential to be engaged and processed by dendritic cells (DCs), nanovaccines consisting of Poly(D,L-lactic-co-glycolic acid) (PLGA)…”
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Transcriptome Analysis Identifies Immune Markers Related to Visceral Leishmaniasis Establishment in the Experimental Model of BALB/c Mice by Agallou, Maria, Athanasiou, Evita, Kammona, Olga, Tastsoglou, Spyros, Hatzigeorgiou, Artemis G, Kiparissides, Costas, Karagouni, Evdokia

“…Visceral leishmaniasis (VL) caused by and . is a potentially fatal disease. To date there are no registered vaccines for disease prevention despite the fact…”
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Detection of Antigen-specific T cells in Spleens of Vaccinated Mice Applying 3 [H]-Thymidine Incorporation Assay and Luminex Multiple Cytokine Analysis Technology by Agallou, Maria, Karagouni, Evdokia

“…For many infectious diseases T cells are an important part of naturally acquired protective immune responses, and inducing these by vaccination has been the…”
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Novel Competitive ELISA Utilizing Trimeric Spike Protein of SARS-CoV-2, Could Identify More Than RBD-RBM Specific Neutralizing Antibodies in Hybrid Sera by Eliadis, Petros, Mais, Annie, Papazisis, Alexandros, Loxa, Eleni K, Dimitriadis, Alexios, Sarrigeorgiou, Ioannis, Backovic, Marija, Agallou, Maria, Zouridakis, Marios, Karagouni, Evdokia, Lazaridis, Konstantinos, Mamalaki, Avgi, Lymberi, Peggy

“…Since the initiation of the COVID-19 pandemic, there has been a need for the development of diagnostic methods to determine the factors implicated in mounting…”
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Transcriptional Profiling of Leishmania infantum Infected Dendritic Cells: Insights into the Role of Immunometabolism in Host-Parasite Interaction by Margaroni, Maritsa, Agallou, Maria, Vasilakaki, Athina, Karagkouni, Dimitra, Skoufos, Giorgos, Hatzigeorgiou, Artemis G., Karagouni, Evdokia

“…Leishmania parasites are capable of effectively invading dendritic cells (DCs), a cell population orchestrating immune responses against several diseases,…”
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A liposomal vaccine promotes strong adaptive immune responses via dendritic cell activation in draining lymph nodes by Agallou, Maria, Margaroni, Maritsa, Tsanaktsidou, Evgenia, Badounas, Fotis, Kammona, Olga, Kiparissides, Costas, Karagouni, Evdokia

“…Subunit proteins provide a safe source of antigens for vaccine development especially for intracellular infections which require the induction of strong…”
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Cellular vaccination with bone marrow-derived dendritic cells pulsed with a peptide of Leishmania infantum KMP-11 and CpG oligonucleotides induces protection in a murine model of visceral leishmaniasis by Agallou, Maria, Margaroni, Maritsa, Karagouni, Evdokia

“…Abstract The use of dendritic cells (DCs) pulsed with defined Leishmania antigens could be a potential immune intervention tool for the induction of protection…”
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Development of a novel squalene/α-tocopherol-based self-emulsified nanoemulsion incorporating Leishmania peptides for induction of antigen-specific immune responses by Margaroni, Maritsa, Tsanaktsidou, Evgenia, Agallou, Maria, Kiparissides, Costas, Kammona, Olga, Karagouni, Evdokia

“…Vaccination has emerged as the most effective strategy to confront infectious diseases, among which is leishmaniasis, that threat public health. Despite…”
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Antibody and T-Cell Subsets Analysis Unveils an Immune Profile Heterogeneity Mediating Long-term Responses in Individuals Vaccinated Against SARS-CoV-2 by Agallou, Maria, Koutsoni, Olga S, Michail, Maria, Zisimopoulou, Paraskevi, Tsitsilonis, Ourania E, Karagouni, Evdokia

“…Based on the fact that coronavirus disease 2019 (COVID-19) is still spreading despite worldwide vaccine administration, there is an imperative need to…”
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Experimental Validation of Multi-Epitope Peptides Including Promising MHC Class I- and II-Restricted Epitopes of Four Known Leishmania infantum Proteins by Agallou, Maria, Athanasiou, Evita, Koutsoni, Olga, Dotsika, Eleni, Karagouni, Evdokia

“…Leishmaniasis is a significant worldwide health problem for which no vaccine exists. Activation of CD4(+) and CD8(+) T cells is crucial for the generation of…”
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Induction of protective cellular immune responses against experimental visceral leishmaniasis mediated by dendritic cells pulsed with the N-terminal domain of Leishmania infantum elongation factor-2 and CpG oligodeoxynucleotides by Agallou, Maria, Pantazi, Eleni, Tsiftsaki, Elisavet, Toubanaki, Dimitra K., Gaitanaki, Catherine, Smirlis, Despina, Karagouni, Evdokia

“…•The N-terminal domain of EF-2 (N-LiEF-2) contained several MHC I and II epitopes.•DCs pulsed with N-LiEF-2 along with CpG ODNs acquired a fully mature…”
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Vaccination with poly(D,L-lactide-co-glycolide) nanoparticles loaded with soluble Leishmania antigens and modified with a TNFα-mimicking peptide or monophosphoryl lipid A confers protection against experimental visceral leishmaniasis by Margaroni, Maritsa, Agallou, Maria, Athanasiou, Evita, Kammona, Olga, Kiparissides, Costas, Gaitanaki, Catherine, Karagouni, Evdokia

“…Visceral leishmaniasis (VL) persists as a major public health problem, and since the existing chemotherapy is far from satisfactory, development of an…”
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Vaccination with Leishmania histone H1-pulsed dendritic cells confers protection in murine visceral leishmaniasis by Agallou, Maria, Smirlis, Despina, Soteriadou, Ketty P, Karagouni, Evdokia

“…Abstract Visceral leishmaniasis is the most severe form of leishmaniases affecting millions of people worldwide often resulting in death despite optimal…”
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Immunoinformatics Approach to Design a Multi-Epitope Nanovaccine against ILeishmania/I Parasite: Elicitation of Cellular Immune Responses by Margaroni, Maritsa, Agallou, Maria, Tsanaktsidou, Evgenia, Kammona, Olga, Kiparissides, Costas, Karagouni, Evdokia

“…Leishmaniasis is a vector-borne disease caused by an intracellular parasite of the genus Leishmania with different clinical manifestations that affect millions…”
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PLGA nanoparticles modified with a TNFα mimicking peptide, soluble Leishmania antigens and MPLA induce T cell priming in vitro via dendritic cell functional differentiation by Margaroni, Maritsa, Agallou, Maria, Kontonikola, Katerina, Karidi, Konstantina, Kammona, Olga, Kiparissides, Costas, Gaitanaki, Catherine, Karagouni, Evdokia

“…[Display omitted] Poly(lactide-co-glycolide) nanoparticles (PLGA NPs) represent a new approach for vaccine delivery due to their ability to be taken up by…”
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