Search Results - "Agak, George W."

Extracellular traps released by antimicrobial TH17 cells contribute to host defense by Agak, George W, Mouton, Alice, Teles, Rosane Mb, Weston, Thomas, Morselli, Marco, Andrade, Priscila R, Pellegrini, Matteo, Modlin, Robert L

“…TH17 cell subpopulations have been defined that contribute to inflammation and homeostasis, yet the characteristics of TH17 cells that contribute to host…”
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Human Regulatory T Cells: Understanding the Role of Tregs in Select Autoimmune Skin Diseases and Post-Transplant Nonmelanoma Skin Cancers by Oparaugo, Nicole Chizara, Ouyang, Kelsey, Nguyen, Nam Phuong N, Nelson, Amanda M, Agak, George W

“…Regulatory T cells (Tregs) play an important role in maintaining immune tolerance and homeostasis by modulating how the immune system is activated. Several…”
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T Cell Extracellular Traps: Tipping the Balance Between Skin Health and Disease by Ouyang, Kelsey, Oparaugo, Nicole, Nelson, Amanda M, Agak, George W

“…The role of extracellular traps (ETs) in the innate immune response against pathogens is well established. ETs were first identified in neutrophils and have…”
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Understanding Type 3 Innate Lymphoid Cells and Crosstalk with the Microbiota: A Skin Connection by To, Thao Tam, Oparaugo, Nicole Chizara, Kheshvadjian, Alexander R, Nelson, Amanda M, Agak, George W

“…Innate lymphoid cells (ILCs) are a diverse population of lymphocytes classified into natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and ILCregs, broadly…”
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Analysis of intracellular communication reveals consistent gene changes associated with early-stage acne skin by Deng, Min, Odhiambo, Woodvine O, Qin, Min, To, Thao Tam, Brewer, Gregory M, Kheshvadjian, Alexander R, Cheng, Carol, Agak, George W

“…A comprehensive understanding of the intricate cellular and molecular changes governing the complex interactions between cells within acne lesions is currently…”
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Transcriptomic Analyses Predict Enhanced Metabolic Activity and Therapeutic Potential of mTOR Inhibitors in Acne-Prone Skin by Sennett, Mackenzie L., Agak, George W., Thiboutot, Diane M., Nelson, Amanda M.

“…Current acne therapies center on preventing new lesions in patients with acne. These therapies were historically found to be beneficial yet were chosen without…”
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Nitric Oxide–Releasing Nanoparticles Prevent Propionibacterium acnes–Induced Inflammation by Both Clearing the Organism and Inhibiting Microbial Stimulation of the Innate Immune Response by Qin, Min, Landriscina, Angelo, Rosen, Jamie M., Wei, Gabrielle, Kao, Stephanie, Olcott, William, Agak, George W., Paz, Karin B., Bonventre, Josephine, Clendaniel, Alicea, Harper, Stacey, Adler, Brandon L., Krausz, Aimee E., Friedman, Joel M., Nosanchuk, Joshua D., Kim, Jenny, Friedman, Adam J.

“…Propionibacterium acnes induction of IL-1 cytokines through the NLRP3 (NLR, nucleotide oligomerization domain-like receptor) inflammasome was recently…”
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A protocol to detect human CD4+ T cell extracellular traps using scanning electron microscopy by Nguyen, Nam Phuong N., Oparaugo, Nicole Chizara, Ouyang, Kelsey, Agak, George W.

“…We present a protocol to detect extracellular traps (ETs) induced by Cutibacterium acnes in cultured TH17 clones. We first describe the isolation of…”
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Keloid pathophysiology: fibroblast or inflammatory disorders? by Nangole, Ferdinand W., Agak, George W.

“…Background: Keloids are defined as a benign dermal fibroproliferative disorder with no malignant potential. They tend to occur following trivial trauma or any…”
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Phenotype and Antimicrobial Activity of Th17 Cells Induced by Propionibacterium acnes Strains Associated with Healthy and Acne Skin by Agak, George W., Kao, Stephanie, Ouyang, Kelsey, Qin, Min, Moon, David, Butt, Ahsan, Kim, Jenny

“…Studies of the human skin microbiome suggest that Propionibacterium acnes strains may contribute differently to skin health and disease. However, the immune…”
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Effect of a fifth round of seasonal malaria chemoprevention in children aged 5–14 years in Dangassa, an area of long transmission in Mali by Konate, Drissa, Diawara, Sory I., Sogoba, Nafomon, Shaffer, Jeffrey G., Keita, Bourama, Cisse, Abdourhamane, Sanogo, Ibrahim, Dicko, Ilo, Guindo, Merepen dite Agnes, Balam, Saidou, Traore, Abdouramane, Kante, Salimata, Dembele, Assitan, Kasse, Fatoumata, Denou, Larissa, Diakite, Seidina A.S., Traore, Karim, M'Baye Thiam, Sidibe, Sanogo, Vincent, Toure, Mahamoudou, Diarra, Ayouba, Agak, George W., Doumbia, Seydou, Diakite, Mahamadou

“…Despite a significant reduction in the burden of malaria in children under five years-old, the efficient implementation of seasonal malaria chemoprevention…”
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Different Propionibacterium acnes Phylotypes Induce Distinct Immune Responses and Express Unique Surface and Secreted Proteomes by Yu, Yang, Champer, Jackson, Agak, George W., Kao, Stephanie, Modlin, Robert L., Kim, Jenny

“…Propionibacterium acnes is a skin commensal bacterium that contributes to the development of acne vulgaris and other infections. Recent work revealed that…”
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Rapid identification of malaria vaccine candidates based on alpha-helical coiled coil protein motif by Villard, Viviane, Agak, George W, Frank, Géraldine, Jafarshad, Ali, Servis, Catherine, Nébié, Issa, Sirima, Sodiomon B, Felger, Ingrid, Arevalo-Herrera, Myriam, Herrera, Socrates, Heitz, Frederic, Bäcker, Volker, Druilhe, Pierre, Kajava, Andrey V, Corradin, Giampietro

“…To identify malaria antigens for vaccine development, we selected alpha-helical coiled coil domains of proteins predicted to be present in the parasite…”
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G2A Attenuates Propionibacterium acnes Induction of Inflammatory Cytokines in Human Monocytes by Park, Andrew J, Agak, George W, Qin, Min, Hisaw, Lisa D, Pirouz, Aslan, Kao, Stephanie, Marinelli, Laura J, Garbán, Hermes J, Thiboutot, Diane, Liu, Philip T, Kim, Jenny

“…Acne vulgaris is a disease of the pilosebaceous unit characterized by increased sebum production, hyperkeratinization, and immune responses to (PA). Here, we…”
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Propionibacterium acnes Induces an IL-17 Response in Acne Vulgaris that Is Regulated by Vitamin A and Vitamin D by Agak, George W., Qin, Min, Nobe, Jennifer, Kim, Myung-Hwa, Krutzik, Stephan R., Tristan, Grogan R., Elashoff, David, Garbán, Hermes J., Kim, Jenny

“…Acne vulgaris is the most common skin disorder affecting millions of people worldwide and inflammation resulting from the immune response targeting…”
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T-Cell Mediated Immunity in Merkel Cell Carcinoma by Ouyang, Kelsey, Zheng, David X, Agak, George W

“…Merkel cell carcinoma (MCC) is a rare and frequently lethal skin cancer with neuroendocrine characteristics. MCC can originate from either the presence of MCC…”
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SLST D1 strains may contribute to skin health by Agak, George W., Thiboutot, Diane M., Zaenglein, Andrea L., Nelson, Amanda M.

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Does Keloid Histology Influence Recurrence? by Nangole, Ferdinand W., Ouyang, Kelsey, Anzala, Omu, Ogeng'o, Julius, Agak, George W., Zuriel, Daniel

“…Keloids are fibroproliferative disorders characterized by high recurrence rates, with few factors known to influence the same. We conducted a study to…”
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Evolution of the facial skin microbiome during puberty in normal and acne skin by Schneider, Andrea M., Nolan, Zachary T., Banerjee, Kalins, Paine, Allison R., Cong, Zhaoyuan, Gettle, Samantha L., Longenecker, Amy L., Zhan, Xiang, Agak, George W., Nelson, Amanda M.

“…Background The composition of the skin microbiome varies from infancy to adulthood and becomes most stable in adulthood. Adult acne patients harbour an ‘acne…”
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Treatment response to isotretinoin correlates with specific shifts in Cutibacterium acnes strain composition within the follicular microbiome by Nolan, Zachary T., Banerjee, Kalins, Cong, Zhaoyuan, Gettle, Samantha L., Longenecker, Amy L., Kawasawa, Yuka I., Zaenglein, Andrea L., Thiboutot, Diane M., Agak, George W., Zhan, Xiang, Nelson, Amanda M.

“…There are no drugs as effective as isotretinoin for acne. Deciphering the changes in the microbiome induced by isotretinoin in the pilosebaceous follicle of…”
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