Search Results - "Agah, Ramtin"

Transforming Growth Factor Beta 1 Induces Neointima Formation Through Plasminogen Activator Inhibitor-1–Dependent Pathways by Otsuka, Goro, Agah, Ramtin, Frutkin, Andrew D, Wight, Thomas N, Dichek, David A

“…OBJECTIVE—The mechanisms through which transforming growth factor (TGF)-β1 promotes intimal growth, and the pathways through which TGF-β1 expression is…”
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Overexpression of transforming growth factor β1 in arterial endothelium causes hyperplasia, apoptosis, and cartilaginous metaplasia by Schulick, Andrew H., Taylor, Allen J., Zuo, Wen, Qiu, Chang-bin, Dong, Gang, Woodward, Robert N., Agah, Ramtin, Roberts, Anita B., Virmani, Renu, Dichek, David A.

“…Uninjured rat arteries transduced with an adenoviral vector expressing an active form of transforming growth factor β1 (TGF-β1) developed a cellular and…”
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Comparison of the safety and efficacy of emboli prevention devices versus platelet glycoprotein IIb/IIIa inhibition during carotid stenting by Chan, Albert W., Yadav, Jay S., Bhatt, Deepak L., Bajzer, Christopher T., Gum, Patricia A., Roffi, Marco, Cho, Leslie, Agah, Ramtin, Topol, Eric J.

“…Distal embolization is the main potential risk of carotid stenting, and techniques to minimize this risk are evolving. Between July 1998 and March 2002, 305…”
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Intra-arterial gemcitabine vs IV gemcitabine PK substudy in patients with locally advanced pancreatic cancer by Zureikat, Amer H., Pishvaian, Michael J., Meredith, Kenneth, Hatoum, Hassan, Zervos, Emmanuel E., Nazemzadeh, Reza, Novelli, Paula M., Tsobanoudis, Alex, Agah, Ramtin

“…728 Background: Localized dual-balloon-mediated, intra-arterial delivery of Gemcitabine (IAG) directly into tumors/tissue can lead to higher local drug potency…”
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Double-Balloon Catheter–Mediated Transarterial Chemotherapy Delivery in a Swine Model: A Mechanism Recruiting the Vasa Vasorum for Localized Therapies by Farsad, Khashayar, Novelli, Paula M., Laing, Christopher, Gandhi, Ripal T., Cynamon, Jacob, López, Claudia S., Stempinski, Erin S., Strasser, Robert, Agah, Ramtin

“…Treatment of hypovascular tumors, such as pancreatic adenocarcinoma, is challenging owing to inefficient drug delivery. This report examines the potential…”
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Rate process model for arterial tissue thermal damage: implications on vessel photocoagulation by Agah, R, Pearce, J A, Welch, A J, Motamedi, M

“…A numerical model for thermal damage to human arterial tissue is presented, based on protein denaturation kinetics. The model involves determination of…”
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Treatment of locally advanced pancreatic cancer using localized trans-arterial micro perfusion of gemcitabine: combined analysis of RR1 and RR2 by Hatoum, Hassan, Rosemurgy, 2nd, Alexander, Bastidas, J Augusto, Zervos, Emmanuel, Muscarella, 2nd, Peter, Edil, Barish H, Cynamon, Jacob, Johnson, D Thor, Thomas, Christopher, Swinson, Bradley M, Nordgren, Aaron, Vitulli, Paul, Nutting, Charles, Gipson, Matthew, Tsobanoudis, Alex, Agah, Ramtin

“…Locally advanced pancreatic cancer (LAPC) comprises 40% of pancreatic cancer diagnoses and has a relatively poor prognosis. Trans-arterial micro perfusion…”
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Targeted intra-arterial gemcitabine vs. continuation of IV gemcitabine plus nab-paclitaxel following induction with sequential IV gemcitabine plus nab-paclitaxel and radiotherapy for unresectable locally advanced pancreatic cancer (TIGeR-PaC): A randomized phase 3 multicenter study by Pishvaian, Michael J., Zureikat, Amer H., Lopez, Charles D., Meredith, Kenneth, Zervos, Emmanuel E., Hatoum, Hassan, Chung, Ki Y., Berg, Daniel James, Ucar, Antonio, Gandhi, Ripal T, Nazemzadeh, Reza, Parikh, Nainesh, Novelli, Paula M., Kouri, Brian, Laing, Christopher, Boone, Brian A., Johnson, Thor, Bates, Susan Elaine, Agah, Ramtin, Goodman, Karyn A.

“…TPS773 Background: Prognosis for locally advanced pancreatic cancer (LAPC) remains dismal even with advances in cancer therapy. Beyond systemic therapies,…”
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Incidence and clinical characteristics of patients with LAPC and mesenteric vein thrombosis and current treatment paradigm by Zureikat, Amer H., Pishvaian, Michael J., Lopez, Charles D., Meredith, Kenneth, Zervos, Emmanuel E., Hatoum, Hassan, Chung, Ki Y., Tsobanoudis, Alex, Berg, Daniel James, Ucar, Antonio, Nazemzadeh, Reza, Bates, Susan Elaine, Goodman, Karyn A., Johnson, Thor, Parikh, Nainesh, Kouri, Brian, Laing, Christopher, Boone, Brian A., Qureshi, Imtiaz, Agah, Ramtin

“…714 Background: Mesenteric venous thrombosis (MVT), defined as complete occlusion of the Superior Mesenteric Vein (SMV) or Main Portal Vein (MPV) is often…”
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Toxicity and efficacy of stereotactic body radiation therapy vs. intensity-modulated radiation therapy for the treatment of locally advanced pancreatic cancer in a phase 3 trial by Goodman, Karyn A., Pishvaian, Michael J., Lopez, Charles D., Meredith, Kenneth, Zervos, Emmanuel E., Hatoum, Hassan, Chung, Ki Y., Tsobanoudis, Alex, Berg, Daniel James, Ucar, Antonio, Nazemzadeh, Reza, Johnson, Thor, Parikh, Nainesh, Kouri, Brian, Laing, Christopher, Boone, Brian A., Qureshi, Imtiaz, Agah, Ramtin, Zureikat, Amer H.

“…713 Background: Locally advanced pancreatic cancer (LAPC) remains one of the deadliest cancers. Radiation is listed as a first line therapy option in treatment…”
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Resection rate of locally advanced pancreatic cancer in gemcitabine plus nab-paclitaxel versus FOLFIRINOX by Sharif, Shahriar, Zureikat, Amer H., Novelli, Paula M., Lopez, Charles D., Kardosh, Adel, Chung, Ki Y., Jones, Wesley B., Hatoum, Hassan, Meredith, Kenneth Lee, Zervos, Emmanuel E., Ucar, Antonio, Gandhi, Ripal T, Nazemzadeh, Reza, Kasi, Pashtoon Murtaza, Vandestraeten, Erik, Decaestecker, Jochen, Delaunoit, Thierry, Li, Charles Charles, Agah, Ramtin, Pishvaian, Michael J.

“…Abstract only 381 Background: There is no established treatment for locally advanced pancreatic cancer (LAPC), but by utilizing the regimens approved for…”
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Sepsis and pancreatic cancer: Biliary stents a significant risk factor in patients undergoing chemotherapy by Li, Charles Charles, Zureikat, Amer H., Novelli, Paula M., Lopez, Charles D., Kardosh, Adel, Chung, Ki Y., Devane, Aron Michael, Hatoum, Hassan, Meredith, Kenneth Lee, Zervos, Emmanuel E., Ucar, Antonio, Gandhi, Ripal T, Nazemzadeh, Reza, Kasi, Pashtoon Murtaza, Decaestecker, Jochen, Vandestraeten, Erik, Delaunoit, Thierry, Sharif, Shahriar, Agah, Ramtin, Pishvaian, Michael J.

“…Abstract only 399 Background: For patients with pancreatic cancer, tumor growth causing obstruction of the bile duct is a common, yet troubling occurrence,…”
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Trans-intra-arterial gemcitabine versus continuation of IV gemcitabine and nab-paclitaxel following radiotherapy for locally advanced pancreatic cancer (TIGeR-PaC) by Pishvaian, Michael J., Goodman, Karyn A., Zervos, Emmanuel E., Muscarella, Peter, Kim, Alexander Y., Bloomston, Mark, Nutting, Charles W., Meredith, Ken Lee, Lavu, Harish, Chuy, Jennifer W., Lee, Justin, Matrana, Marc Ryan, Lavarias, Clifford, Gellert, Scott, Agah, Ramtin

“…Abstract only TPS529 Background: Treatment of locally advanced pancreatic cancer (LAPC) remains a challenge, and novel therapy options for local treatment of…”
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Abstract CT084: Targeted intra-arterial gemcitabine vs. continuation of IV gemcitabine plus nab-paclitaxel following Induction with sequential IV gemcitabine plus nab-paclitaxel and radiotherapy for unresectable locally advanced pancreatic cancer (TIGeR-PaC) - phase III trial interim analysis by Pishvaian, Michael, Zureikat, Amer, Lopez, Charles, Meredith, Kenneth, Zervos, Emmanuel, Hatoum, Hassan, Chung, Ki, Berg, Daniel J., Ucar, Antonio, Gandhi, Ripal, Nazemzadeh, Reza, Nainesh, Parikh, Novelli, Paula, Kouri, Brian, Laing, Christopher, Boone, Brian, Johnson, Thor, Bates, Susan, Goodman, Karyn, Agah, Ramtin

“…Abstract Background: Treatment of locally advanced pancreatic cancer (LAPC) remains a clinical challenge with a median survival of 16-18 months1. Control of…”
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Safety Study of Targeted and Localized Intra-Arterial Delivery of Gemcitabine in Patients with Locally Advanced Pancreatic Adenocarcinoma by Rosemurgy, Alexander S., Ross, Sharona B., Vitulli, Paul L., Malek, Reza, Li, Jaili, Agah, Ramtin

“…Purpose: This is a first-in-man safety study in locally advanced pancreatic cancer (LAPC) using a targeted intra-arterial delivery catheter (RenovoCath™)…”
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Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo by Agah, R, Frenkel, P A, French, B A, Michael, L H, Overbeek, P A, Schneider, M D

“…Mouse models of human disease can be generated by homologous recombination for germline loss-of-function mutations. However, embryonic-lethal phenotypes and…”
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Safety Study of Targeted and Localized Intra-Arterial Delivery of Gemcitabine in Patients with Locally Advanced Pancreatic Adenocarcinoma by Rosemurgy, Alexander S, Ross, Sharona B, Vitulli, Paul L, Malek, Reza, Li, Jaili, Agah, Ramtin

“…This is a first-in-man safety study in locally advanced pancreatic cancer (LAPC) using a targeted intra-arterial delivery catheter (RenovoCath™). Twenty…”
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Conditional targeting: inducible deletion by Cre recombinase by O'Neal, Kelly R, Agah, Ramtin

“…Tissue specific gene knockouts using Cre recombinase can have broad applicability in murine disease models of cardiovascular disease. The Cre system has been…”
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Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo by Agah, R, Kirshenbaum, L A, Abdellatif, M, Truong, L D, Chakraborty, S, Michael, L H, Schneider, M D

“…Irreversible exit from the cell cycle precludes the ability of cardiac muscle cells to increase cell number after infarction. Using adenoviral E1A, we…”
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Overexpression of Transforming Growth Factor β 1 in Arterial Endothelium Causes Hyperplasia, Apoptosis, and Cartilaginous Metaplasia by Schulick, Andrew H., Taylor, Allen J., Zuo, Wen, Qiu, Chang-Bin, Dong, Gang, Woodward, Robert N., Agah, Ramtin, Roberts, Anita B., Virmani, Renu, Dichek, David A.

“…Uninjured rat arteries transduced with an adenoviral vector expressing an active form of transforming growth factor β 1 (TGF-β 1) developed a cellular and…”
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