Association of vitamin D receptor gene polymorphisms in Iranian patients with inflammatory bowel disease

Background and Aims: The vitamin D receptor (VDR) gene maps to a region on chromosome 12 shown to be linked to inflammatory bowel disease (IBD). Many studies have recognized the relation of VDR gene polymorphisms with inflammatory and autoimmune disorders. Determining the frequency of these polymor...

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Published in:	Journal of gastroenterology and hepatology Vol. 23; no. 12; pp. 1816 - 1822
Main Authors:	Naderi, Nosratollah, Farnood, Alma, Habibi, Manijeh, Derakhshan, Faramarz, Balaii, Hedieh, Motahari, Zahra, Agah, Mohammad R, Firouzi, Farzad, Rad, Mahta G, Aghazadeh, Rahim, Zojaji, Homayoun, Zali, Mohammad R
Format:	Journal Article
Language:	English
Published:	Melbourne, Australia Blackwell Publishing Asia 01-12-2008 Wiley-Blackwell
Subjects:	Adolescent Adult Aged Asian Continental Ancestry Group - genetics Biological and medical sciences Case-Control Studies Colitis, Ulcerative - ethnology Colitis, Ulcerative - genetics Colitis, Ulcerative - pathology Crohn Disease - ethnology Crohn Disease - genetics Crohn Disease - pathology Female Gastroenterology. Liver. Pancreas. Abdomen Gene Frequency Genetic Predisposition to Disease Humans IBD Iran - epidemiology Male Medical sciences Middle Aged Other diseases. Semiology Phenotype polymorphism Polymorphism, Genetic Receptors, Calcitriol - genetics Stomach. Duodenum. Small intestine. Colon. Rectum. Anus vitamin D receptor Young Adult Iran Human Crohn disease Vitamin D Gastroenterology Digestive diseases Intestinal disease IBD vitamin D receptor Inflammatory disease Polymorphism Ulcerative colitis
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Summary:	Background and Aims: The vitamin D receptor (VDR) gene maps to a region on chromosome 12 shown to be linked to inflammatory bowel disease (IBD). Many studies have recognized the relation of VDR gene polymorphisms with inflammatory and autoimmune disorders. Determining the frequency of these polymorphisms and their possible relation with IBD can improve understandings about the genetic background of these diseases. The objective of this study was to assess the association of VDR gene polymorphisms (Apa I, Taq I, Bsm I, Fok I) with IBD in Iran. Methods: In this case control designed study 150 patients with ulcerative colitis, 80 patients with Crohn's disease and 150 Age and Sex matched healthy controls from Iranian origin were enrolled. These patients were referred to a tertiary center during a two‐year period (2004–2006). Assessment of VDR gene polymorphisms was performed by the polymerase chain reaction—restriction fragment length polymorphism (PCR‐RFLP) method. The genotype–phenotype association for these polymorphisms was analyzed. Results: Only the frequency of the Fok I polymorphism was significantly higher in ulcerative colitis and Crohn's groups. The frequency of the polymorphic allele f was higher in ulcerative colitis and Crohn's patients comparing with controls (P = 0.011 and P < 0.001, respectively). The f/f genotype was also significantly more frequent (P < 0.001), while the F/F genotype was less presented in Crohn's patients compared to controls (P < 0.001). No genotype–phenotype association was observed with any mutations. Conclusions: This study suggests a probable association of the Fok I polymorphism in VDR receptor gene and Crohn's susceptibility in Iranian population.
Bibliography:	ArticleID:JGH5525 istex:0EA9F9B5DC76F7C01445597DC9E56BE0E9224467 ark:/67375/WNG-SX4X7TG9-7 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0815-9319 1440-1746
DOI:	10.1111/j.1440-1746.2008.05525.x