Search Results - "Agúndez, José A.G"

Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process by Caudle, Kelly E, Klein, Teri E, Hoffman, James M, Muller, Daniel J, Whirl-Carrillo, Michelle, Gong, Li, McDonagh, Ellen M, Sangkuhl, Katrin, Thorn, Caroline F, Schwab, Matthias, Agundez, Jose A G, Freimuth, Robert R, Huser, Vojtech, Lee, Ming Ta Michael, Iwuchukwu, Otito F, Crews, Kristine R, Scott, Stuart A, Wadelius, Mia, Swen, Jesse J, Tyndale, Rachel F, Stein, C Michael, Roden, Dan, Relling, Mary V, Williams, Marc S, Johnson, Samuel G

“…The Clinical Pharmacogenetics Implementation Consortium (CPIC) publishes genotype-based drug guidelines to help clinicians understand how available genetic…”
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An Update on the Neurochemistry of Essential Tremor by Jiménez-Jiménez, Félix Javier, Alonso-Navarro, Hortensia, García-Martín, Elena, Agúndez, José A G

“…The pathophysiology and neurochemical mechanisms of essential tremor (ET) are not fully understood, because only a few post-mortem studies have been reported,…”
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Detection of Genomic Variations in BRCA1 and BRCA2 Genes by Long-Range PCR and Next-Generation Sequencing by Hernan, Imma, Borràs, Emma, de Sousa Dias, Miguel, Gamundi, María José, Mañé, Begoña, Llort, Gemma, Agúndez, José A.G, Blanca, Miguel, Carballo, Miguel

“…Advances in sequencing technologies, such as next-generation sequencing (NGS), represent an opportunity to perform genetic testing in a clinical scenario. In…”
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PharmVar GeneFocus: CYP2D6 by Nofziger, Charity, Turner, Amy J., Sangkuhl, Katrin, Whirl‐Carrillo, Michelle, Agúndez, José A.G., Black, John L., Dunnenberger, Henry M., Ruano, Gualberto, Kennedy, Martin A., Phillips, Michael S., Hachad, Houda, Klein, Teri E., Gaedigk, Andrea

“…The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the…”
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Association between restless legs syndrome and other movement disorders by Alonso-Navarro, Hortensia, García-Martín, Elena, Agúndez, José A.G, Jiménez-Jiménez, Félix Javier

“…OBJECTIVEThis review focuses on the possible association between restless legs syndrome (RLS) and movement disorders, including Parkinson disease (PD), other…”
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Developments in pharmacogenetics, pharmacogenomics, and personalized medicine by Abad-Santos, Francisco, Aliño, Salvador F., Borobia, Alberto M., García-Martín, Elena, Gassó, Patricia, Maroñas, Olalla, Agúndez, José A.G.

“…The development of Pharmacogenetics and Pharmacogenomics in Western Europe is highly relevant in the worldwide scenario. Despite the usually low institutional…”
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Sleep Disorders in Patients with Choreic Syndromes by Jiménez-Jiménez, Félix Javier, Alonso-Navarro, Hortensia, García-Martín, Elena, Agúndez, José A.G.

“…Purpose of Review Patients with different types of choreic syndromes, specially those with Huntington’s (HD) and Wilson’s (WD) diseases, report frequent sleep…”
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Current and Future Neuropharmacological Options for the Treatment of Essential Tremor by Hortensia Alonso-Navarro, Elena García-Martín, José A.G. Agúndez, Félix J. Jiménez-Jiménez

“…Background: Essential Tremor (ET) is likely the most frequent movement disorder. In this review, we have summarized the current pharmacological options for the…”
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Genetic determinants of metamizole metabolism modify the risk of developing anaphylaxis by García-Martín, Elena, Esguevillas, Gara, Blanca-López, Natalia, García-Menaya, Jesús, Blanca, Miguel, Amo, Gemma, Canto, Gabriela, Martínez, Carmen, Cordobés, Concepción, Agúndez, José A.G

“…Metamizole is a NSAID that has been banned in several countries because of its toxicity. It is often involved in selective hypersensitivity reactions and most…”
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COMT gene and risk for Parkinson’s disease: a systematic review and meta-analysis by Jiménez-Jiménez, Félix J, Alonso-Navarro, Hortensia, García-Martín, Elena, Agúndez, José A.G

“…BACKGROUND/AIMSSeveral single-nucleotide polymorphisms (SNPs) in the catechol-O-methyltransferase (COMT) gene have been associated with the risk of developing…”
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The potential role of pharmacogenomics and biotransformation in hypersensitivity reactions to paracetamol by Agúndez, José A.G, Gómez-Tabales, Javier, Ruano, Francisco, García-Martin, Elena

“…PURPOSE OF REVIEWThe aim of the present review is to discuss recent advances supporting a role of paracetamol metabolism in hypersensitivity reactions to this…”
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Gender and functional CYP2C and NAT2 polymorphisms determine the metabolic profile of metamizole by Martínez, Carmen, Andreu, Inmaculada, Amo, Gemma, Miranda, Miguel A., Esguevillas, Gara, Torres, María José, Blanca-López, Natalia, Blanca, Miguel, García-Martín, Elena, Agúndez, José A.G.

“…Metamizole is a pain-killer drug that has been banned in some countries because of its toxicity, but it is still used in many countries due to its effective…”
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Drug and xenobiotic biotransformation in the blood-brain barrier: a neglected issue by Agúndez, José A G, Jiménez-Jiménez, Félix J, Alonso-Navarro, Hortensia, García-Martín, Elena

“…Drug biotransformation is a crucial mechanism for facilitating the elimination of chemicals from the organism and for decreasing their pharmacological…”
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SLC1A2 rs3794087 variant and risk for essential tremor: a systematic review and meta-analysis by Jiménez-Jiménez, Félix J, Alonso-Navarro, Hortensia, García-Martín, Elena, Agúndez, José A.G

“…BACKGROUND/OBJECTIVERecently, a genome-wide association study showed a statistically significant association between the rs3794087 single nucleotide…”
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Drug metabolism and hypersensitivity reactions to drugs by Agúndez, José A.G, Mayorga, Cristobalina, García-Martin, Elena

“…PURPOSE OF REVIEWThe aim of the present review was to discuss recent advances supporting a role of drug metabolism, and particularly of the generation of…”
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Association Between Vitamin D Receptor rs731236 (Taq1) Polymorphism and Risk for Restless Legs Syndrome in the Spanish Caucasian Population by Jiménez-Jiménez, Félix Javier, García-Martín, Elena, Alonso-Navarro, Hortensia, Martínez, Carmen, Zurdo, Martín, Turpín-Fenoll, Laura, Millán-Pascual, Jorge, Adeva-Bartolomé, Teresa, Cubo, Esther, Navacerrada, Francisco, Rojo-Sebastián, Ana, Rubio, Lluisa, Ortega-Cubero, Sara, Pastor, Pau, Calleja, Marisol, Plaza-Nieto, José Francisco, Pilo-De-La-Fuente, Belén, Arroyo-Solera, Margarita, García-Albea, Esteban, Agúndez, José A.G.

“…Several recent works suggest a possible role of vitamin D deficiency in the etiology or restless legs syndrome (RLS). We analyzed the possible relationship of…”
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LINGO1 and risk for essential tremor: Results of a meta-analysis of rs9652490 and rs11856808 by Jiménez-Jiménez, Félix Javier, García-Martín, Elena, Lorenzo-Betancor, Oswaldo, Pastor, Pau, Alonso-Navarro, Hortensia, Agúndez, José A.G

“…Abstract Background/objectives Recently, a genome-wide association study revealed a significant statistical association between LINGO1 rs9652490 and rs11856808…”
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Gene variants and haplotypes modifying transcription factor binding sites in the human cyclooxygenase 1 and 2 (PTGS1 and PTGS2) genes by Agundez, Jose A G, Gonzalez-Alvarez, David L, Vega-Rodriguez, Miguel A, Botello, Emilia, Garcia-Martin, Elena

“…Cyclooxygenases (prostaglandin-endoperoxide synthases, (EC 1.14.99.1) 1 and 2 (COX-1 and COX-2)) are key enzymes with a highly functional and pharmacological…”
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Neuronal Nitric Oxide Synthase (nNOS, NOS1) rs693534 and rs7977109 Variants and Risk for Migraine by García-Martín, Elena, Martínez, Carmen, Serrador, Mercedes, Alonso-Navarro, Hortensia, Navacerrada, Francisco, García-Albea, Esteban, Agúndez, José A.G., Jiménez-Jiménez, Félix Javier

“…Background/Objectives Many biochemical, pharmacological, neuropathological, and experimental data suggest a possible role of nitric oxide in the pathogenesis…”
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No association of the SLC1A2 rs3794087 allele with risk for essential tremor in the Spanish population by García-Martín, Elena, Martínez, Carmen, Alonso-Navarro, Hortensia, Benito-León, Julián, Lorenzo-Betancor, Oswaldo, Pastor, Pau, Ortega-Cubero, Sara, López-Alburquerque, Tomás, Agúndez, José A.G, Jiménez-Jiménez, Félix J

“…BACKGROUND/AIMSA recent genome-wide association study and other replication studies have suggested that the rs3794087 single nucleotide polymorphism in the…”
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