Search Results - "Afzal, Obaid"

An Efficient Synthesis of 1-(1,3-Dioxoisoindolin-2-yl)-3-aryl Urea Analogs as Anticancer and Antioxidant Agents: An Insight into Experimental and In Silico Studies by Afzal, Obaid, Ahsan, Mohamed Jawed

“…The present investigation reports the efficient multistep synthesis of 1-(1,3-dioxoisoindolin-2-yl)-3-aryl urea analogs ( - ) in good yields. All the…”
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A review on anticancer potential of bioactive heterocycle quinoline by Afzal, Obaid, Kumar, Suresh, Haider, Md Rafi, Ali, Md Rahmat, Kumar, Rajiv, Jaggi, Manu, Bawa, Sandhya

“…The advent of Camptothecin added a new dimension in the field anticancer drug development containing quinoline motif. Quinoline scaffold plays an important…”
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Eco-friendly stability-indicating RP-HPTLC method for sildenafil analysis, characterization and biological evaluation of its oxidized stress degradation product by Abdel-Kader, Maged S., Alam, Prawez, Soliman, Gamal A., Al-Shdefat, Ramadan, Afzal, Obaid

“…A feasible and cost effective reverse-phase high-performance thin layer chromatography (RP-HPTLC) based method was developed for the quantification of…”
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Nanoparticles in Drug Delivery: From History to Therapeutic Applications by Afzal, Obaid, Altamimi, Abdulmalik S A, Nadeem, Muhammad Shahid, Alzarea, Sami I, Almalki, Waleed Hassan, Tariq, Aqsa, Mubeen, Bismillah, Murtaza, Bibi Nazia, Iftikhar, Saima, Riaz, Naeem, Kazmi, Imran

“…Current research into the role of engineered nanoparticles in drug delivery systems (DDSs) for medical purposes has developed numerous fascinating…”
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Application of green nanoemulsion to treat contaminated water (bulk aqueous solution) with azithromycin by Hussain, Afzal, Afzal, Obaid, Altamimi, Abdulmalik S.A., Ali, Raisuddin

“…The present work aimed to remove azithromycin (AZM) from the contaminated aqueous system using a water/ethanol/transcutol/Capryol-90 green nanoemulsion. The…”
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Exploring Nanocarriers as Treatment Modalities for Skin Cancer by Adnan, Mohammad, Akhter, Md Habban, Afzal, Obaid, Altamimi, Abdulmalik S A, Ahmad, Irfan, Alossaimi, Manal A, Jaremko, Mariusz, Emwas, Abdul-Hamid, Haider, Tanweer, Haider, Md Faheem

“…Cancer is a progressive disease of multi-factorial origin that has risen worldwide, probably due to changes in lifestyle, food intake, and environmental…”
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Prodrug Rewards in Medicinal Chemistry: An Advance and Challenges Approach for Drug Designing by Husain, Asif, Monga, Jyoti, Narwal, Smita, Singh, Gurvirender, Rashid, Mohammad, Afzal, Obaid, Alatawi, Abdurahhman, Almadani, Norah M

“…This article emphasizes the importance of prodrugs and their diverse spectrum of effects in the field of developing novel drugs for a variety of biological…”
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Neuroprotective role of chrysin‐loaded poly(lactic‐co‐glycolic acid) nanoparticle against kindling‐induced epilepsy through Nrf2/ARE/HO‐1 pathway by Zhang, Ying, Zhao, Jing, Afzal, Obaid, Kazmi, Imran, Al‐Abbasi, Fahad A., Altamimi, Abdulmalik S. A., Yang, Zhen

“…Chrysin is the major bioactive compound of blue passionflower, an important medicinal plant used in traditional herbal formulations since ancient times. In the…”
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Green Tea Catechins Attenuate Neurodegenerative Diseases and Cognitive Deficits by Afzal, Obaid, Dalhat, Mahmood Hassan, Altamimi, Abdulmalik S. A, Rasool, Rabia, Alzarea, Sami I, Almalki, Waleed Hassan, Murtaza, Bibi Nazia, Iftikhar, Saima, Nadeem, Shamaila, Nadeem, Muhammad Shahid, Kazmi, Imran

“…Neurodegenerative diseases exert an overwhelming socioeconomic burden all around the globe. They are mainly characterized by modified protein accumulation that…”
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Amelioration of Cancer Employing Chitosan, Its Derivatives, and Chitosan-Based Nanoparticles: Recent Updates by Virmani, Tarun, Kumar, Girish, Sharma, Ashwani, Pathak, Kamla, Akhtar, Md Sayeed, Afzal, Obaid, Altamimi, Abdulmalik S A

“…The limitations associated with the conventional treatment of cancer have necessitated the design and development of novel drug delivery systems based mainly…”
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Polysaccharide-Based Nanomedicines Targeting Lung Cancer by Bhat, Asif Ahmad, Gupta, Gaurav, Alharbi, Khalid Saad, Afzal, Obaid, Altamimi, Abdulmalik S A, Almalki, Waleed Hassan, Kazmi, Imran, Al-Abbasi, Fahad A, Alzarea, Sami I, Chellappan, Dinesh Kumar, Singh, Sachin Kumar, MacLoughlin, Ronan, Oliver, Brian G, Dua, Kamal

“…A primary illness that accounts for a significant portion of fatalities worldwide is cancer. Among the main malignancies, lung cancer is recognised as the most…”
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Adjuvant Novel Nanocarrier-Based Targeted Therapy for Lung Cancer by Sarma, Kangkan, Akther, Md Habban, Ahmad, Irfan, Afzal, Obaid, Altamimi, Abdulmalik S A, Alossaimi, Manal A, Jaremko, Mariusz, Emwas, Abdul-Hamid, Gautam, Preety

“…Lung cancer has the lowest survival rate due to its late-stage diagnosis, poor prognosis, and intra-tumoral heterogeneity. These factors decrease the…”
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Analgesic and Anticancer Activity of Benzoxazole Clubbed 2-Pyrrolidinones as Novel Inhibitors of Monoacylglycerol Lipase by Afzal, Obaid, Altamimi, Abdulmalik Saleh Alfawaz, Shahroz, Mir Mohammad, Sharma, Hemant Kumar, Riadi, Yassine, Hassan, Md Quamrul

“…Ten benzoxazole clubbed 2-pyrrolidinones ( - ) as human monoacylglycerol lipase inhibitors were designed on the criteria fulfilling the structural requirements…”
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Baicalin-Loaded Lipid-Polymer Hybrid Nanoparticles Inhibiting the Proliferation of Human Colon Cancer: Pharmacokinetics and In Vivo Evaluation by Riadi, Yassine, Afzal, Obaid, Geesi, Mohammed H, Almalki, Waleed H, Singh, Tanuja

“…This research work is focused on pharmacokinetic and biochemical experiments to assess baicalin-loaded lipid-polymer hybrid nanoparticles (LPHNPs) with…”
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Drug Delivery Challenges and Current Progress in Nanocarrier-Based Ocular Therapeutic System by Akhter, Md Habban, Ahmad, Irfan, Alshahrani, Mohammad Y, Al-Harbi, Alhanouf I, Khalilullah, Habibullah, Afzal, Obaid, Altamimi, Abdulmalik S A, Najib Ullah, Shehla Nasar Mir, Ojha, Abhijeet, Karim, Shahid

“…Drug instillation via a topical route is preferred since it is desirable and convenient due to the noninvasive and easy drug access to different segments of…”
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Edaravone and benidipine protect myocardial damage by regulating mitochondrial stress, apoptosis signalling and cardiac biomarkers against doxorubicin-induced cardiotoxicity by Hassan, Md Quamrul, Akhtar, Md Sayeed, Afzal, Obaid, Hussain, Ibraheem, Akhtar, Mohd, Haque, Syed Ehtaishamul, Najmi, Abul Kalam

“…Background: Doxorubicin (DOX) is a potential chemotherapeutic agent but its use is restricted due to cardiotoxicity. Edaravone is a potent-free radical…”
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EGF‐functionalized lipid–polymer hybrid nanoparticles of 5‐fluorouracil and sulforaphane with enhanced bioavailability and anticancer activity against colon carcinoma by Li, Shumin, Xu, Zhongkai, Alrobaian, Majed, Afzal, Obaid, Kazmi, Imran, Almalki, Waleed H., Altamimi, Abdulmalik Saleh Alfawaz, Al‐Abbasi, Fahad A., Alharbi, Khalid S, Altowayan, Waleed M, Singh, Tanuja, Akhter, Md Habban, Gupta, Manish, Rahman, Mahfoozur, Beg, Sarwar

“…The present research work describes development of dual drug‐loaded lipid–polymer hybrid nanoparticles (LPHNPs) of anticancer therapeutics for the management…”
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Cationic Solid Lipid Nanoparticles of Resveratrol for Hepatocellular Carcinoma Treatment: Systematic Optimization, in vitro Characterization and Preclinical Investigation by Rahman, Mahfoozur, Almalki, Waleed H, Afzal, Obaid, Alfawaz Altamimi, Abdulmalik Saleh, Kazmi, Imran, Al-Abbasi, Fahad A, Choudhry, Hani, Alenezi, Sattam K, Barkat, Md Abul, Beg, Sarwar, Kumar, Vikas, Alhalmi, Abdulsalam

“…The present study focuses on the development and evaluation of the resveratrol (RV)-loaded cationic solid lipid nanoparticles (RV-c-SLNs) for the management of…”
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Potential Efficacy of β-Amyrin Targeting Mycobacterial Universal Stress Protein by In Vitro and In Silico Approach by Beg, Md Amjad, Shivangi, Afzal, Obaid, Akhtar, Md Sayeed, Altamimi, Abdulmalik S. A., Hussain, Afzal, Imam, Md Ali, Ahmad, Mohammad Naiyaz, Chopra, Sidharth, Athar, Fareeda

“…The emergence of drug resistance and the limited number of approved antitubercular drugs prompted identification and development of new antitubercular…”
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Synthesis and Anticancer Evaluation of 4-Chloro-2-((5-aryl-1,3,4-oxadiazol-2-yl)amino)phenol Analogues: An Insight into Experimental and Theoretical Studies by Afzal, Obaid, Ali, Amena, Ali, Abuzer, Altamimi, Abdulmalik Saleh Alfawaz, Alossaimi, Manal A., Bakht, Md Afroz, Salahuddin, Alamri, Mubarak A., Ahsan, Md. Faiyaz, Ahsan, Mohamed Jawed

“…We report herein the synthesis, docking studies and biological evaluation of a series of new 4-chloro-2-((5-aryl-1,3,4-oxadiazol-2-yl)amino)phenol analogues…”
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