Ocular dynamics of systemic aqueous extracts of Xylopia aethiopica (African guinea pepper) seeds on visually active volunteers

Ocular dynamics of systemic aqueous extracts of Xylopia aethiopica (African guinea pepper) seeds on visually active volunteers

Xylopia aethiopica, African guinea pepper, is an angiosperm belonging to the family Annonecae, and used mainly as spice and in traditional medicine. The ocular dynamics of bolus consumption of 300 mg total dose was undertaken on visually active volunteers with a view to finding its ocular effects or...

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Bibliographic Details
Published in:Journal of ethnopharmacology Vol. 86; no. 2; pp. 139 - 142
Main Authors: Igwe, S.A., Afonne, J.C., Ghasi, S.I.
Format: Journal Article
Language:English
Published: Shannon Elsevier Ireland Ltd 01-06-2003
Elsevier
Subjects:
Adult
Annonaceae
Biological and medical sciences
Convergence, Ocular - drug effects
Esophoria
Exophoria
General pharmacology
Humans
Intraocular pressure
Intraocular Pressure - drug effects
Male
Medical sciences
Nigeria
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Postnatal
Visual Acuity - drug effects
Xylopia aethiopica
Nigeria
Africa
Exophoria
Xylopia aethiopica
Postnatal
Esophoria
Intraocular pressure
Antiglaucomatous agent
Human
Seeds
Spice
Extract
Biological activity
Medicinal plant
Eye
Treatment
Folk medicine
Dicotyledones
Angiospermae
Plant origin
Spermatophyta
Annonaceae
Phytotherapy
Mechanism of action
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Summary:Xylopia aethiopica, African guinea pepper, is an angiosperm belonging to the family Annonecae, and used mainly as spice and in traditional medicine. The ocular dynamics of bolus consumption of 300 mg total dose was undertaken on visually active volunteers with a view to finding its ocular effects or complications. Results showed that the aqueous extract of X. aethiopica was neither a miotic nor a mydriatic, but lowered the intraocular pressure (17.48%), reduced the near point of convergence (31.1%) and increased the amplitude of accommodation (8.98%) which are positively correlated ( r=0.95). On the other hand, the systemic extract had no effect on the visual acuity at far and near as well as the phoria status at the appropriate distances. The convergence excess resulted in esophoria and the increased amplitude of accommodation placed greater demand on accommodation mechanism without any discomfort. The nonspecific mechanism of action makes it a safer spice which can be exploited in the management of exophoria and raised intraocular pressure (glaucoma) in instances where the efficacy of the older conventional drugs is insufficient.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(02)00371-9