Search Results - "Afink, Gijs B"

ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice by Ho, Lena, van Dijk, Marie, Chye, Sam Tan Jian, Messerschmidt, Daniel M., Chng, Serene C., Ong, Sheena, Yi, Ling Ka, Boussata, Souad, Goh, Grace Hui-Yi, Afink, Gijs B., Lim, Chin Yan, Dunn, N. Ray, Solter, Davor, Knowles, Barbara B., Reversade, Bruno

“…Preeclampsia (PE) is a gestational hypertensive syndrome affecting between 5 and 8% of all pregnancies. Although PE is the leading cause of fetal and maternal…”
Get full text

Role of soluble endoglin in BMP9 signaling by Lawera, Aleksandra, Tong, Zhen, Thorikay, Midory, Redgrave, Rachael E., Cai, Jie, van Dinther, Maarten, Morrell, Nicholas W., Afink, Gijs B., Charnock-Jones, D. Stephen, Arthur, Helen M., Dijke, Peter ten, Li, Wei

“…Endoglin (ENG) is a coreceptor of the transforming growth factor-β (TGFβ) family signaling complex, which is highly expressed on endothelial cells and plays a…”
Get full text

Corrigendum to “COVID-19 mRNA vaccination during pregnancy does not harm syncytiotrophoblast development” [International Journal of Infectious Diseases, 140C (2024) pages 95-98] by van Voorden, Jantine, de Groot, Christianne J.M., Ris-Stalpers, Carrie, Afink, Gijs B., van Leeuwen, Elisabeth

Get full text

Differentially expressed genes in the pre-eclamptic placenta: a systematic review and meta-analysis by Kleinrouweler, C Emily, van Uitert, Miranda, Moerland, Perry D, Ris-Stalpers, Carrie, van der Post, Joris A M, Afink, Gijs B

“…To systematically review the literature on human gene expression data of placental tissue in pre-eclampsia and to characterize a meta-signature of…”
Get full text

COVID-19 mRNA vaccination during pregnancy does not harm syncytiotrophoblast development by van Voorden, Jantine, de Groot, Christianne J.M., Ris-Stalpers, Carrie, Afink, Gijs B., van Leeuwen, Elisabeth

“…•Maternal response to COVID-19 messenger RNA vaccine does not impair trophoblast development.•SARS-CoV-2 antibodies in maternal blood do not impair trophoblast…”
Get full text

Meta-Analysis of Placental Transcriptome Data Identifies a Novel Molecular Pathway Related to Preeclampsia by van Uitert, Miranda, Moerland, Perry D, Enquobahrie, Daniel A, Laivuori, Hannele, van der Post, Joris A M, Ris-Stalpers, Carrie, Afink, Gijs B

“…Studies using the placental transcriptome to identify key molecules relevant for preeclampsia are hampered by a relatively small sample size. In addition, they…”
Get full text

The idiopathic preterm delivery methylation profile in umbilical cord blood DNA by Fernando, Febilla, Keijser, Remco, Henneman, Peter, van der Kevie-Kersemaekers, Anne-Marie F, Mannens, Marcel Mam, van der Post, Joris Am, Afink, Gijs B, Ris-Stalpers, Carrie

“…Preterm delivery is the leading cause of neonatal morbidity and mortality. Two-thirds of preterm deliveries are idiopathic. The initiating molecular mechanisms…”
Get full text

Associations of vomiting and antiemetic use in pregnancy with levels of circulating GDF15 early in the second trimester: A nested case-control study by Petry, Clive J, Ong, Ken K, Burling, Keith A, Barker, Peter, Goodburn, Sandra F, Perry, John R B, Acerini, Carlo L, Hughes, Ieuan A, Painter, Rebecca C, Afink, Gijs B, Dunger, David B, O'Rahilly, Stephen

“…Although nausea and vomiting are very common in pregnancy, their pathogenesis is poorly understood. We tested the hypothesis that circulating growth and…”
Get full text

Knockdown of Splicing Complex Protein PCBP2 Reduces Extravillous Trophoblast Differentiation Through Transcript Switching by Georgiadou, Danai, Boussata, Souad, Keijser, Remco, Janssen, Dianta A. M., Afink, Gijs B., van Dijk, Marie

“…Mutations in the LINC-HELLP non-coding RNA ( HELLPAR ) have been associated with familial forms of the pregnancy-specific HELLP syndrome. These mutations…”
Get full text

TBX2, a Novel Regulator of Labour by Fernando, Febilla, Veenboer, Geertruda J M, Oudijk, Martijn A, Kampman, Marlies A M, Heida, Karst Y, Lagendijk, Louise J M, van der Post, Joris A M, Jongejan, Aldo, Afink, Gijs B, Ris-Stalpers, Carrie

“…: Therapeutic interventions targeting molecular factors involved in the transition from uterine quiescence to overt labour are not substantially reducing the…”
Get full text

GFAP promoter driven transgenic expression of PDGFB in the mouse brain leads to glioblastoma in a Trp53 null background by Hede, Sanna-Maria, Hansson, Inga, Afink, Gijs B., Eriksson, Anna, Nazarenko, Inga, Andrae, Johanna, Genove, Guillem, Westermark, Bengt, Nistér, Monica

“…Glioblastomas are the most common and malignant astrocytic brain tumors in human adults. The tumor suppressor gene TP53 is commonly mutated and/or lost in…”
Get full text

Brain abnormalities and glioma-like lesions in mice overexpressing the long isoform of PDGF-A in astrocytic cells by Nazarenko, Inga, Hedrén, Anna, Sjödin, Hanna, Orrego, Abiel, Andrae, Johanna, Afink, Gijs B, Nistér, Monica, Lindström, Mikael S

“…Deregulation of platelet-derived growth factor (PDGF) signaling is a hallmark of malignant glioma. Two alternatively spliced PDGF-A mRNAs have been described,…”
Get full text

High-quality human preimplantation embryos stimulate endometrial stromal cell migration via secretion of microRNA hsa-miR-320a by Berkhout, Robbert P, Keijser, Remco, Repping, Sjoerd, Lambalk, Cornelis B, Afink, Gijs B, Mastenbroek, Sebastiaan, Hamer, Geert

“…Abstract STUDY QUESTION How do high-quality human preimplantation embryos influence the endometrium to promote their own implantation? SUMMARY ANSWER…”
Get full text

EP300 facilitates human trophoblast stem cell differentiation by van Voorden, A Jantine, Keijser, Remco, Veenboer, Geertruda J M, Lopes Cardozo, Solange A, Diek, Dina, Vlaardingerbroek, Jennifer A, van Dijk, Marie, Ris-Stalpers, Carrie, van Pelt, Ans M M, Afink, Gijs B

“…Early placenta development involves cytotrophoblast differentiation into extravillous trophoblast (EVT) and syncytiotrophoblast (STB). Defective trophoblast…”
Get full text

The apelinergic-axis in human preeclamptic pregnancies: A systematic review by Georgiadou, Danai, Afink, Gijs B., van Dijk, Marie

“…•Circulating Apelin levels are increased in early-onset/severe preeclampsia.•Apelin levels are decreased in severe preeclamptic placenta tissues.•Circulating…”
Get full text

Peptide hormone ELABELA enhances extravillous trophoblast differentiation, but placenta is not the major source of circulating ELABELA in pregnancy by Georgiadou, Danai, Boussata, Souad, Ranzijn, Willemijn H. M., Root, Leah E. A., Hillenius, Sanne, bij de Weg, Jeske M., Abheiden, Carolien N. H., de Boer, Marjon A., de Vries, Johanna I. P., Vrijkotte, Tanja G. M., Lambalk, Cornelis B., Kuijper, Esther A. M., Afink, Gijs B., van Dijk, Marie

“…Preeclampsia is a frequent gestational hypertensive disorder with equivocal pathophysiology. Knockout of peptide hormone ELABELA (ELA) has been shown to cause…”
Get full text

Resistance Artery Creatine Kinase mRNA and Blood Pressure in Humans by Karamat, Fares A, Oudman, Inge, Ris-Stalpers, Carrie, Afink, Gijs B, Keijser, Remco, Clark, Joseph F, van Montfrans, Gert A, Brewster, Lizzy M

“…Hypertension remains the main risk factor for cardiovascular death. Environmental and biological factors are known to contribute to the condition, and…”
Get full text

Plasma ceramide is increased and associated with proteinuria in women with pre-eclampsia and HELLP syndrome by Amraoui, Fouad, Hassani Lahsinoui, Hajar, Spijkers, Leon J.A., Vogt, Liffert, Peters, Stephan L.M., Wijesinghe, Dayanjan S., Warncke, Urszula O., Chalfant, Charles E., Ris-Stalpers, Carrie, van den Born, Bert-Jan H., Afink, Gijs B.

“…•Plasma, but not placental, ceramide is elevated in women with pre-eclampsia/HELLP.•Plasma sphingolipid levels are not correlated with placental sphingolipid…”
Get full text

Initial characterization of C16orf89, a novel thyroid-specific gene by Afink, Gijs B, Veenboer, Geertruda, de Randamie, Janine, Keijser, Remco, Meischl, Christof, Niessen, Hans, Ris-Stalpers, Carrie

“…Thyroid hormone is prerequisite for proper fetal and postnatal neurodevelopment, growth, and metabolism. Although much progress has been made in the…”
Get more information

Soluble fms-like tyrosine kinase 1 and soluble endoglin are elevated circulating anti-angiogenic factors in pre-eclampsia by Liu, Zhen, Afink, Gijs B, Dijke, Peter ten

“…Abstract Pre-eclampsia, characterized by hypertension and proteinuria, affects approximately 3–5% of all pregnancies worldwide and is a major cause of maternal…”
Get full text