Multifocal visual evoked potential for evaluation of open-angle glaucoma

Background: To correlate multifocal visual evoked potential (mf VEP) findings with static automated perimetry (SAP) and spectral-domain optical coherence tomography (SD-OCT) in eyes with primary openangle glaucoma (POAG).Methods: This cross-sectional study included a consecutive sample of 40 eyes of...

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Published in:	Medical hypothesis, discovery and innovation in ophthalmology Vol. 10; no. 3; pp. 114 - 120
Main Authors:	Afify, Mostafa EmadEldeen Hussien Mohamed, Abdelgawad, Randa Hesham Ali, Hamdi, Momen Mahmoud, El-Shazly, Amany Abd El-Fattah, Abdelshafik, Mohamed Adel
Format:	Journal Article
Language:	English
Published:	Austin International Virtual Ophthalmic Research Center (IVORC) 17-11-2021 International Virtual Ophthalmic Research Center
Subjects:	Automation Cross-sectional studies Diabetic retinopathy Glaucoma Hypotheses Ophthalmology Optics Original Signal to noise ratio Tomography Ultrasonic imaging Visual acuity
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Summary:	Background: To correlate multifocal visual evoked potential (mf VEP) findings with static automated perimetry (SAP) and spectral-domain optical coherence tomography (SD-OCT) in eyes with primary openangle glaucoma (POAG).Methods: This cross-sectional study included a consecutive sample of 40 eyes of 40 patients with POAG. The participants underwent a complete ophthalmologic assessment, axial length (AL) measurement, and assessments with SAP, SD-OCT, and mf VEP.Results: POAG cases were aged 49.70 ± 14.16 years (mean ± SD) and most were females (n = 24, 60%). For eyes of patients with POAG, the mf VEP upper-ring signal-to-noise ratio (SNR) showed a significant negative correlation with best-corrected logMAR visual acuity (r = - 0.33; P = 0.038), and a significant positive correlation with the superior hemifield of the visual field (VF) and the inferior-quadrant retinal nerve fiber layer (RNFL) thickness (r = + 0.34; P = 0.030; r = + 0.51; P < 0.001, respectively). Similarly, the mf VEP lower-ring SNR showed a significant negative correlation with best-corrected logMAR visual acuity (r = - 0.36; P = 0.024) and a significant positive correlation with the inferior hemifield of the VF and superior quadrant RNFL thickness (r = + 0.55; P < 0.001 and r = + 0.70; P < 0.001, respectively).Conclusions: mf VEP is a promising tool for objective assessment of the VF in patients with POAG, as it is positively correlated with the VF and OCT RNFL thickness. Future longitudinal studies with a larger sample size and a specific glaucoma subtype, along with multiple follow-up evaluations, are warranted to confirm our preliminary results.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2322-3219 2322-4436 2322-3219
DOI:	10.51329/mehdiophthal1429