Search Results - "Afifi, Tarek H."

Development of Polyvinyl Alcohol/Kaolin Sponges Stimulated by Marjoram as Hemostatic, Antibacterial, and Antioxidant Dressings for Wound Healing Promotion by Tamer, Tamer M, Alsehli, Mosa H, Omer, Ahmed M, Afifi, Tarek H, Sabet, Maysa M, Mohy-Eldin, Mohamed S, Hassan, Mohamed A

“…The predominant impediments to cutaneous wound regeneration are hemorrhage and bacterial infections that lead to extensive inflammation with lethal impact. We…”
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A New Family of Benzo[ h ]Chromene Based Azo Dye: Synthesis, In-Silico and DFT Studies with In Vitro Antimicrobial and Antiproliferative Assessment by Abd-El-Aziz, Alaa S, Alsaggaf, Azhaar, Assirey, Eman, Naqvi, Arshi, Okasha, Rawda M, Afifi, Tarek H, Hagar, Mohamed

“…The high biological activity of the chromene compounds coupled with the intriguing optical features of azo chromophores prompted our desire to construct novel…”
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Synthesis and Characterization of a New Class of Chromene-Azo Sulfonamide Hybrids as Promising Anticancer Candidates with the Exploration of Their EGFR, hCAII, and MMP-2 Inhibitors Based on Molecular Docking Assays by Alblewi, Fawzia F., Alsehli, Mosa H., Hritani, Zainab M., Eskandrani, Areej, Alsaedi, Wael H., Alawad, Majed O., Elhenawy, Ahmed A., Ahmed, Hanaa Y., El-Gaby, Mohamed S. A., Afifi, Tarek H., Okasha, Rawda M.

“…In this study, novel selective antitumor compounds were synthesized based on their fundamental pharmacophoric prerequisites associated with EGFR inhibitors. A…”
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DFT and In-silico Investigations, along with In-vitro Antitumor and Antimicrobial Assessments of Pharmacological Molecules by Alsehli, Mosa H, Seth, Daya S, El-Gaby, Mohamed S A, Okasha, Rawda M, Hagar, Mohamed, Afifi, Tarek H, Naqvi, Arshi

“…Molecules bearing an active methylene bridge are one of the most fruitful and remarkable precursors that have been incorporated into the synthetic strategy of…”
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Synthesis of 9-Hydroxy-1H-Benzo[f]chromene Derivatives with Effective Cytotoxic Activity on MCF7/ADR, P-Glycoprotein Inhibitors, Cell Cycle Arrest and Apoptosis Effects by Albalawi, Fawzia F., El-Nassag, Mohammed A. A., El-Eisawy, Raafat A., Mohamed, Mahmoud Basseem I., Fouda, Ahmed M., Afifi, Tarek H., Elhenawy, Ahmed A., Mora, Ahmed, El-Agrody, Ahmed M., El-Mawgoud, Heba K. A.

“…β-Enaminonitriles bearing 9-hydroxy-1H-benzo[f]chromene moiety was synthesized. The targeted compounds were evaluated for their anti-proliferative activity…”
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Synthesis, Biological Assessment, and Structure Activity Relationship Studies of New Flavanones Embodying Chromene Moieties by Assirey, Eman, Alsaggaf, Azhaar, Naqvi, Arshi, Moussa, Ziad, Okasha, Rawda M, Afifi, Tarek H, Abd-El-Aziz, Alaa S

“…Novel flavanones that incorporate chromene motifs are synthesized via a one-step multicomponent reaction. The structures of the new chromenes are elucidated by…”
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Design of New Benzo[h]chromene Derivatives: Antitumor Activities and Structure-Activity Relationships of the 2,3-Positions and Fused Rings at the 2,3-Positions by Okasha, Rawda M, Alblewi, Fawzia F, Afifi, Tarek H, Naqvi, Arshi, Fouda, Ahmed M, Al-Dies, Al-Anood M, El-Agrody, Ahmed M

“…A series of novel 4 -benzo[ ]chromenes , - , , ; 7 -benzo[ ]chromeno[2,3- ]pyrimidines - , , and 14 -benzo[ ]chromeno[3,2- ][1,2,4]triazolo[1,5- ]pyrimidine…”
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Design and Synthesis of Novel Heterocyclic-Based 4H-benzo[h]chromene Moieties: Targeting Antitumor Caspase 3/7 Activities and Cell Cycle Analysis by Alblewi, Fawzia, Okasha, Rawda, Eskandrani, Areej, Afifi, Tarek, Mohamed, Hany, Halawa, Ahmed, Fouda, Ahmed, Al-Dies, Al-Anood, Mora, Ahmed, El-Agrody, Ahmed

“…Novel fused chromenes (4,7–11) and pyrimidines (12–16) were designed, synthesized, and evaluated for their mammary gland breast cancer (MCF-7), human colon…”
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Introducing novel potent anticancer agents of 1H-benzo[f]chromene scaffolds, targeting c-Src kinase enzyme with MDA-MB-231 cell line anti-invasion effect by Ahmed, Hany E. A., El-Nassag, Mohammed A. A., Hassan, Ahmed H., Okasha, Rawda M., Ihmaid, Saleh, Fouda, Ahmed M., Afifi, Tarek H., Aljuhani, Ateyatallah, El-Agrody, Ahmed M.

“…In our effort to develop novel and powerful agents with anti-proliferative activity, two new series of 1H-benzo[f]chromene derivatives, 4a-h and 6a-h, were…”
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Structural Characterization and Antimicrobial Activities of 7H-Benzo[h]chromeno[2,3-d]pyrimidine and 14H-Benzo[h]chromeno[3,2-e][1,2,4]triazolo[1,5-c] pyrimidine Derivatives by Okasha, Rawda M, Albalawi, Fawzia F, Afifi, Tarek H, Fouda, Ahmed M, Al-Dies, Al-Anood M, El-Agrody, Ahmed M

“…Three new series of chromene molecules have been synthesized in order to explore their antimicrobial activity. The series encompass 2-substituted…”
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Novel 2-Hydroselenonicotinonitriles and Selenopheno[2, 3-b]pyridines: Efficient Synthesis, Molecular Docking-DFT Modeling, and Antimicrobial Assessment by Abdellattif, Magda H., Abdel-Rahman, Adel A. H., Arief, Mohamed Mohamed Helmy, Mouneir, Samar M., Ali, Amena, Hussien, Mostafa A., Okasha, Rawda M., Afifi, Tarek H., Hagar, Mohamed

“…Selenium containing heterocyclic compounds gained great interest as bioactive molecules as of late. This report explores the design, synthesis,…”
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Catalytic Activity of Sulfated and Phosphated Catalysts towards the Synthesis of Substituted Coumarin by Nagi R. E. Radwan, Mohamed Hagar, Tarek H. Afifi, Fahd Al-wadaani, Rawda M. Okasha

“…New modified acidic catalysts were prepared from the treatment of silica, titania and silica prepared from hydrolyzed tetraethyl orthosilicate (TEOS) with…”
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Design of Thermochromic Polynorbornene Bearing Spiropyran Chromophore Moieties: Synthesis, Thermal Behavior and Dielectric Barrier Discharge Plasma Treatment by Ahmed, Saleh A, Okasha, Rawda M, Khairou, Khalid S, Afifi, Tarek H, Mohamed, Abdel-Aleam H, Abd-El-Aziz, Alaa S

“…A new class of thermochromic polynorbornene with pendent spiropyran moieties has been synthesized. Functionalization of norbornene monomers with…”
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Novel chromenes and benzochromenes bearing arylazo moiety: molecular docking, in-silico admet, in-vitro antimicrobial and anticancer screening by Afifi, Tarek H., Riyadh, Sayed M., Deawaly, Anwar A., Naqvi, Arshi

“…Novel derivatives of benzochromene 9a – e and chromene 10a – e were synthesized via multi components reaction that utilizes azo dyes, malononitrile, and…”
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First example of Azo-Sulfa conjugated chromene moieties: Synthesis, characterization, antimicrobial assessment, docking simulation as potent class I histone deacetylase inhibitors and antitumor agents by Okasha, Rawda M., Alsehli, Mosa, Ihmaid, Saleh, Althagfan, Sultan S., El-Gaby, Mohamed S.A., Ahmed, Hany E.A., Afifi, Tarek H.

“…[Display omitted] •Novel and primary model of sulfonamide compounds encompassing a chromene azo motif.•Cytotoxic screening was performed against three cancer…”
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Microwave synthesis of novel halogenated β-enaminonitriles linked 9-bromo-1H-benzo[f]chromene moieties: Induces cell cycle arrest and apoptosis in human cancer cells via dual inhibition of topoisomerase I and II by Fouda, Ahmed M., Assiri, Mohammed A., Mora, Ahmed, Ali, Tarik E., Afifi, Tarek H., El-Agrody, Ahmed M.

“…Novel halogenated β-enaminonitriles linked 9-bromo-1H-benzo[f]-chromene moieties with dual inhibition of Topoisomerase I and II. [Display omitted]…”
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Antimicrobial screening and pharmacokinetic profiling of novel phenyl-[1,2,4]triazolo[4,3-a]quinoxaline analogues targeting DHFR and E. coli DNA gyrase B by Omar, Abdelsattar M., Alswah, Mohamed, Ahmed, Hany E.A., Bayoumi, Ashraf H., El-Gamal, Kamal M., El-Morsy, Ahmed, Ghiaty, Adel, Afifi, Tarek H., Sherbiny, Farag F., Mohammed, Adel Saad, Mansour, Baseem Awad

“…A series of novel [1,2,4]triazolo[4,3-a]quinoxaline derivatives were synthesized and evaluated for their antimicrobial inhibiting activity. Compound 6e…”
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Antiproliferative effect, cell cycle arrest and apoptosis generation of novel synthesized anticancer heterocyclic derivatives based 4H-benzo[h]chromene by Alblewi, Fawzia F., Okasha, Rawda M., Hritani, Zainab M., Mohamed, Hany M., El-Nassag, Mohammed A.A., Halawa, Ahmed H., Mora, Ahmed, Fouda, Ahmed M., Assiri, Mohammed A., Al-Dies, Al-Anood M., Afifi, Tarek H., El-Agrody, Ahmed M.

“…[Display omitted] •Design of novel fused chromene and pyrimidine derivatives as promising anticancer agents.•The cytotoxic activity of the new molecules was…”
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A proficient microwave synthesis with structure elucidation and the exploitation of the biological behavior of the newly halogenated 3-amino-1H-benzo[f]chromene molecules, targeting dual inhibition of topoisomerase II and microtubules by Fouda, Ahmed M., Okasha, Rawda M., Alblewi, Fawzia F., Mora, Ahmed, Afifi, Tarek H, El-Agrody, Ahmed M.

“…[Display omitted] •β-enamionitriles, linked 8-bromo-1H-benzo[f]chromene moieties were synthesized as potential anticancer agents.•The cytotoxic activity was…”
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Thermodynamic Parameters of Non-isothermal Degradation of a New Family of Organometallic Dendrimer with Isoconversional Methods by Joraid, Ahmad A., Okasha, Rawda M., Al-Maghrabi, Mahdi A., Afifi, Tarek H., Agatemor, Christian, Abd-El-Aziz, Alaa S.

“…The objective of this work is to obtain the thermodynamic parameters (the changes in enthalpy, Gibbs free energy, and entropy) of two degradation steps…”
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