Search Results - "Affrime, MB"

QT and QTc Interval With Standard and Supratherapeutic Doses of Darifenacin, a Muscarinic M 3 Selective Receptor Antagonist for the Treatment of Overactive Bladder by Serra, Denise B., Affrime, Melton B., Bedigian, Martin P., Greig, Gerard, Milosavljev, Slavica, Skerjanec, Andrej, Wang, Yibin

“…Prolongation of QT interval on an electrocardiogram is a valuable predictor of a drug's ability to cause potentially fatal ventricular tachyarrhythmia…”
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Loratadine administered concomitantly with erythromycin: pharmacokinetic and electrocardiographic evaluations by Brannan, M D, Reidenberg, P, Radwanski, E, Shneyer, L, Lin, C C, Cayen, M N, Affrime, M B

“…To evaluate the effects of coadministration of loratadine and erythromycin on the pharmacokinetics and electrocardiographic repolarization (QTc)…”
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Comparative Pharmacokinetics of Oral Ceftibuten, Cefixime, Cefaclor, and Cefuroxime Axetil in Healthy Volunteers by Nix, David E., Symonds, William T., Hyatt, Judith M., Wilton, John H., Teal, Marilyn A., Reidenberg, Pascale, Affrime, Melton B.

“…Study Objective. To compare the pharmacokinetics of ceftibuten, cefixime, cefuroxime axetil, and cefaclor after oral administration. Design. Randomized,…”
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Pharmacodynamic interaction between the new selective cholesterol absorption inhibitor ezetimibe and simvastatin by Kosoglou, Teddy, Meyer, Ingo, Veltri, Enrico P., Statkevich, Paul, Yang, Bo, Zhu, Yali, Mellars, Lillian, Maxwell, Stephen E., Patrick, James E., Cutler, David L., Batra, Vijay K., Affrime, Melton B.

“…Aims  The primary aims of these two single‐centre, randomized, evaluator‐blind, placebo/positive‐controlled, parallel‐group studies were to evaluate the…”
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Mometasone furoate has minimal effects on the hypothalamic-pituitary-adrenal axis when delivered at high doses by Affrime, M B, Kosoglou, T, Thonoor, C M, Flannery, B E, Herron, J M

“…To investigate the potential for mometasone furoate (MF) to exert systemic effects following administration by dry powder inhaler (DPI) or metered-dose inhaler…”
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Ribavirin dosing in chronic hepatitis C: Application of population pharmacokinetic-pharmacodynamic models by Jen, Juif, Laughlin, Mark, Chung, Carol, Heft, Samuel, Affrime, Melton B., Gupta, Samir K., Glue, Paul, Hajian, Gerald

“…Background Combination therapy of ribavirin with interferon alfa‐2b and pegylated interferon alfa‐2b is currently approved for the treatment of chronic…”
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Attenuation of proinflammatory response by recombinant human IL-10 in human endotoxemia: effect of timing of recombinant human IL-10 administration by Pajkrt, D, Camoglio, L, Tiel-van Buul, MC, de Bruin, K, Cutler, DL, Affrime, MB, Rikken, G, van der Poll, T, ten Cate, JW, van Deventer, SJ

“…To determine the effects of IL-10 on cytokine and granulocyte responses during endotoxemia, two groups of eight healthy male volunteers were challenged with…”
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In vivo effects of interleukin-10 on human cytochrome P450 activity by Gorski, J. Christopher, Hall, Stephen D., Becker, Paula, Affrime, Melton B., Cutler, David L., Haehner‐Daniels, Barbara

“…Background Injection of lipopolysaccharide into human volunteers leads to an increase in serum interleukin‐1β, interleukin‐6, and tumor necrosis factor‐α and a…”
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Bioavailability and Metabolism of Mometasone Furoate following Administration by Metered-Dose and Dry-Powder Inhalers in Healthy Human Volunteers by Affrime, Melton B., Cuss, Francis, Padhi, Desmond, Wirth, Mark, Pai, Sudhakar, Clement, Robert P., Lim, Josephine, Kantesaria, Bhavna, Alton, Kevin, Cayen, Mitchell N.

“…These studies were conducted to assess the systemic bioavailability of mometasone furoate (MF) administered by both the dry‐powder inhaler (DPI) and the…”
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Pharmacodynamics of subcutaneous recombinant human interleukin-10 in healthy volunteers by Huhn, Richard D., Radwanski, Elaine, Gallo, Jose, Affrime, Melton B., Sabo, Ron, Gonyo, Gerilyn, Monge, April, Cutler, David L.

“…Interleukin‐10 inhibits T‐lymphocyte activation and proliferation and lipopolysaccharide‐induced monocyte production of proinflammatory cytokines. Fifty‐four…”
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Safety and tolerability of once-daily mometasone furoate aqueous nasal spray in children by Brannan, Melvin D., Herron, Jerry M., Affrime, Melton B.

“…Sensitive and reproducible assessments of hypothalamic-pituitary-adrenal (HPA) axis function were used to assess the systemic exposure and tolerability of…”
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Pharmacokinetics and Immunomodulatory Properties of Intravenously Administered Recombinant Human Interleukin-10 in Healthy Volunteers by Huhn, Richard D., Radwanski, Elaine, O'Connell, Sean M., Sturgill, Marc G., Clarke, Laura, Cody, Ronald P., Affrime, Melton B., Cutler, David L.

“…Normal volunteers received single doses of recombinant human interleukin-10 (rhIL-10; n = 6 per group) or placebo (n = 3 per group) by intravenous injection to…”
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Evaluation of the pharmacokinetics and electrocardiographic pharmacodynamics of loratadine with concomitant administration of ketoconazole or cimetidine by Kosoglou, T., Salfi, M., Lim, J. M., Batra, V. K., Cayen, M. N., Affrime, M. B.

“…Aims  To evaluate whether ketoconazole or cimetidine alter the pharmacokinetics of loratadine, or its major metabolite, desloratadine (DCL), or alter the…”
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Population pharmacokinetics of temozolomide in cancer patients by JEN, J. Frank, CUTLER, David L, PAI, Sudhakar M, BATRA, Vijay K, AFFRIME, Melton B, ZAMBAS, Demetris N, HEFT, Samuel, HAJIAN, Gerald

“…To evaluate covariate effects on the pharmacokinetics of temozolomide in cancer patients, and to explore the dose-pharmacokinetics-toxicity relationship of…”
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The pharmacokinetics, electrocardiographic effects, and tolerability of loratadine syrup in children aged 2 to 5 years by Salmun, Luis M., Herron, Jerry M., Banfield, Christopher, Padhi, Desmond, Lorber, Richard, Affrime, Melton B.

“…Abstract We assessed the pharmacokinetics and tolerability of 5 mg loratadine syrup (1 mg/mL) in children aged 2 to 5 years. Two studies were undertaken. A…”
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Pharmacokinetics and leukocyte responses of recombinant human interleukin-10 by RADWANSKI, E, CHAKRABORTY, A, VAN WART, S, HUHN, R. D, CUTLER, D. L, AFFRIME, M. B, JUSKO, W. J

“…To study the pharmacokinetics and ex vivo leukocyte responses of recombinant human IL-10 (rHuIL-10) following single s.c. and i.v. dosing. A randomized two-way…”
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Systemic bioavailability of inhaled corticosteroids: appropriate and comparable methodology by Affrime, M B, Banfield, C, Nolop, K

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Regional lung deposition of a technetium 99m-labeled formulation of mometasone furoate administered by hydrofluoroalkane 227 metered-dose inhaler by Pickering, Hannah, Pitcairn, Gary R., Hirst, Peter H., Bacon, Rachel E., Newman, Stephen P., Affrime, Melton B., Marino, Mark

“…Background: A new inhaled suspension formulation of mometasone furoate (MF), a potent corticosteroid with minimal systemic availability, has been developed for…”
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Effects of felbamate on the pharmacokinetics of a low-dose combination oral contraceptive by Saano, V, Glue, P, Banfield, C R, Reidenberg, P, Colucci, R D, Meehan, J W, Haring, P, Radwanski, E, Nomeir, A, Lin, C C

“…The effects of felbamate on the pharmacokinetics of a low-dose combination oral contraceptive containing 30 micrograms ethinyl estradiol and 75 micrograms…”
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Clinical, hematologic, and immunologic effects of interleukin-10 in humans by FUCHS, A. C, GRANOWITZ, E. V, CUTLER, D. L, GRINT, P. C, DINARELLO, C. A, SHAPIRO, L, VANNIER, E, LONNEMANN, G, ANGEL, J. B, KENNEDY, J. S, RABSON, A. R, RADWANSKI, E, AFFRIME, M. B

“…We conducted a double-blind, placebo-controlled study to investigate the safety, pharmacokinetics, and immunological properties of interleukin-10 (IL-10)…”
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