Search Results - "Affrime, M. B."

Evaluation of the pharmacokinetics and electrocardiographic pharmacodynamics of loratadine with concomitant administration of ketoconazole or cimetidine by Kosoglou, T., Salfi, M., Lim, J. M., Batra, V. K., Cayen, M. N., Affrime, M. B.

“…Aims  To evaluate whether ketoconazole or cimetidine alter the pharmacokinetics of loratadine, or its major metabolite, desloratadine (DCL), or alter the…”
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Attenuation of proinflammatory response by recombinant human IL-10 in human endotoxemia: effect of timing of recombinant human IL-10 administration by Pajkrt, D, Camoglio, L, Tiel-van Buul, MC, de Bruin, K, Cutler, DL, Affrime, MB, Rikken, G, van der Poll, T, ten Cate, JW, van Deventer, SJ

“…To determine the effects of IL-10 on cytokine and granulocyte responses during endotoxemia, two groups of eight healthy male volunteers were challenged with…”
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In vivo effects of interleukin-10 on human cytochrome P450 activity by Gorski, J. Christopher, Hall, Stephen D., Becker, Paula, Affrime, Melton B., Cutler, David L., Haehner‐Daniels, Barbara

“…Background Injection of lipopolysaccharide into human volunteers leads to an increase in serum interleukin‐1β, interleukin‐6, and tumor necrosis factor‐α and a…”
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Bioavailability and Metabolism of Mometasone Furoate following Administration by Metered-Dose and Dry-Powder Inhalers in Healthy Human Volunteers by Affrime, Melton B., Cuss, Francis, Padhi, Desmond, Wirth, Mark, Pai, Sudhakar, Clement, Robert P., Lim, Josephine, Kantesaria, Bhavna, Alton, Kevin, Cayen, Mitchell N.

“…These studies were conducted to assess the systemic bioavailability of mometasone furoate (MF) administered by both the dry‐powder inhaler (DPI) and the…”
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Pharmacodynamics of subcutaneous recombinant human interleukin-10 in healthy volunteers by Huhn, Richard D., Radwanski, Elaine, Gallo, Jose, Affrime, Melton B., Sabo, Ron, Gonyo, Gerilyn, Monge, April, Cutler, David L.

“…Interleukin‐10 inhibits T‐lymphocyte activation and proliferation and lipopolysaccharide‐induced monocyte production of proinflammatory cytokines. Fifty‐four…”
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Safety and tolerability of once-daily mometasone furoate aqueous nasal spray in children by Brannan, Melvin D., Herron, Jerry M., Affrime, Melton B.

“…Sensitive and reproducible assessments of hypothalamic-pituitary-adrenal (HPA) axis function were used to assess the systemic exposure and tolerability of…”
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Pharmacokinetics and Immunomodulatory Properties of Intravenously Administered Recombinant Human Interleukin-10 in Healthy Volunteers by Huhn, Richard D., Radwanski, Elaine, O'Connell, Sean M., Sturgill, Marc G., Clarke, Laura, Cody, Ronald P., Affrime, Melton B., Cutler, David L.

“…Normal volunteers received single doses of recombinant human interleukin-10 (rhIL-10; n = 6 per group) or placebo (n = 3 per group) by intravenous injection to…”
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Loratadine administered concomitantly with erythromycin: pharmacokinetic and electrocardiographic evaluations by Brannan, M D, Reidenberg, P, Radwanski, E, Shneyer, L, Lin, C C, Cayen, M N, Affrime, M B

“…To evaluate the effects of coadministration of loratadine and erythromycin on the pharmacokinetics and electrocardiographic repolarization (QTc)…”
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Population pharmacokinetics of temozolomide in cancer patients by JEN, J. Frank, CUTLER, David L, PAI, Sudhakar M, BATRA, Vijay K, AFFRIME, Melton B, ZAMBAS, Demetris N, HEFT, Samuel, HAJIAN, Gerald

“…To evaluate covariate effects on the pharmacokinetics of temozolomide in cancer patients, and to explore the dose-pharmacokinetics-toxicity relationship of…”
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Single‐dose pharmacokinetics of felbamate in patients with renal dysfunction by Glue, P., Sulowicz, W., Colucci, R., Banfield, C., Pai, S., Lin, C., Affrime, M. B.

“…Aims The purpose of this study was to evaluate the effects of renal impairment on the single‐dose pharmacokinetics of the antiepileptic felbamate…”
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The pharmacokinetics, electrocardiographic effects, and tolerability of loratadine syrup in children aged 2 to 5 years by Salmun, Luis M., Herron, Jerry M., Banfield, Christopher, Padhi, Desmond, Lorber, Richard, Affrime, Melton B.

“…Abstract We assessed the pharmacokinetics and tolerability of 5 mg loratadine syrup (1 mg/mL) in children aged 2 to 5 years. Two studies were undertaken. A…”
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Single and multiple dose pharmacokinetics of felbamate in the elderly by Richens, A., Banfield, C. R., Salfi, M., Nomeir, A., Lin, C. C., Jensen, P., Affrime, M. B., Glue, P.

“…Aims The objective of this study was to compare the pharmacokinetics, safety and tolerability of the antiepileptic drug felbamate in young and elderly healthy…”
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Pharmacokinetics and leukocyte responses of recombinant human interleukin-10 by RADWANSKI, E, CHAKRABORTY, A, VAN WART, S, HUHN, R. D, CUTLER, D. L, AFFRIME, M. B, JUSKO, W. J

“…To study the pharmacokinetics and ex vivo leukocyte responses of recombinant human IL-10 (rHuIL-10) following single s.c. and i.v. dosing. A randomized two-way…”
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Disposition of Recombinant Human Interleukin-10 in Subjects with Various Degrees of Renal Function by Andersen, Scott R., Lambrecht, Lawrence J., Swan, Suzanne K., Cutler, David L., Radwanski, Elaine, Affrime, Melton B., Garaud, Jean-Jacques

“…The pharmacokinetics of intravenously administered recombinant human interleukin‐10 (rHuIL‐10) were evaluated in 18 subjects with creatinine clearances (Clcr)…”
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Pharmacokinetics of flutamide in patients with renal insufficiency by ANJUM, S, SWAN, S. K, LAMBRECHT, L. J, RADWANSKI, E, CUTLER, D. L, AFFRIME, M. B, HALSTENSON, C. E

“…Aims The aim of this study was to determine the pharmacokinetic parameters of flutamide, a nonsteroidal antiandrogenic compound, and its pharmacologically…”
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Clinical, hematologic, and immunologic effects of interleukin-10 in humans by FUCHS, A. C, GRANOWITZ, E. V, CUTLER, D. L, GRINT, P. C, DINARELLO, C. A, SHAPIRO, L, VANNIER, E, LONNEMANN, G, ANGEL, J. B, KENNEDY, J. S, RABSON, A. R, RADWANSKI, E, AFFRIME, M. B

“…We conducted a double-blind, placebo-controlled study to investigate the safety, pharmacokinetics, and immunological properties of interleukin-10 (IL-10)…”
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Pharmacokinetics of the triazole antifungal agent genaconazole in healthy men after oral and intravenous administration by Mojaverian, P, Radwanski, E, Affrime, M B, Cayen, M N, Lin, C C

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Lack of hypothalamic-pituitary-adrenal axis suppression with once-daily or twice-daily beclomethasone dipropionate aqueous nasal spray administered to patients with allergic rhinitis by Brannan, Melvin D., Herron, Jerry M., Reidenberg, Pascale, Affrime, Melton B.

“…The potential for a newly developed, double-strength (0.084%) beclomethasone dipropionate (BDP) aqueous (AQ) nasal suspension to produce effects associated…”
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Comparative Pharmacokinetics of Oral Ceftibuten, Cefixime, Cefaclor, and Cefuroxime Axetil in Healthy Volunteers by Nix, David E., Symonds, William T., Hyatt, Judith M., Wilton, John H., Teal, Marilyn A., Reidenberg, Pascale, Affrime, Melton B.

“…Study Objective. To compare the pharmacokinetics of ceftibuten, cefixime, cefuroxime axetil, and cefaclor after oral administration. Design. Randomized,…”
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Interleukin-10 inhibits activation of coagulation and fibrinolysis during human endotoxemia by PAJKRT, D, VAN DER POLL, T, LEVI, M, CUTLER, D. L, AFFRIME, M. B, VAN DEN ENDE, A, TEN CATE, J. W, VAN DEVENTER, S. J. H

“…Interleukin-10 (IL-10) has been found to inhibit lipopolysaccharide (LPS)-induced tissue factor expression by monocytes in vitro. To determine the effects of…”
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