Search Results - "Affholter, Joseph A"

Molecular evolution by staggered extension process (StEP) in vitro recombination by Zhao, Huimin, Giver, Lori, Shao, Zhixin, Affholter, Joseph A, Arnold, Frances H

“…We have developed a simple and efficient method for in vitro mutagenesis and recombination of polynucleotide sequences. The staggered extension process (StEP)…”
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Haloalkane Dehalogenases:  Structure of a Rhodococcus Enzyme by Newman, Janet, Peat, Thomas S, Richard, Ruth, Kan, Lynn, Swanson, Paul E, Affholter, Joseph A, Holmes, Ian H, Schindler, John F, Unkefer, Clifford J, Terwilliger, Thomas C

“…The hydrolytic haloalkane dehalogenases are promising bioremediation and biocatalytic agents. Two general classes of dehalogenases have been reported from…”
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Human Insulin-Degrading Enzyme Shares Structural and Functional Homologies with E. coli Protease III by Affholter, Joseph A., Fried, Victor A., Roth, Richard A.

“…A proteinase with high affinity for insulin has been proposed to play a role in the cellular processing of this hormone. A complementary DNA (cDNA) coding for…”
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Colorless green ideas by Tobin, Matthew, Affholter, Joseph A, Stemmer, Willem P.C, Minshull, Jeremy

“…Who among us hasn't wondered where, exactly, that other red sock has disappeared to, only to find that one's entire collection of white laundry now exhibits a…”
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Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes by Affholter, J A, Hsieh, C L, Francke, U, Roth, R A

“…We have recently described the isolation of a cDNA encoding an enzyme thought to be involved in the degradation of insulin by insulin-responsive tissues. This…”
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Identification of residues in the insulin molecule important for binding to insulin-degrading enzyme by Affholter, Joseph A, Cascieri, Margaret A, Bayne, Marvin L, Brange, Jens, Casaretto, Monika, Roth, Richard A

“…Insulin-degrading enzyme (IDE) hydrolyzes insulin at a limited number of sites. Although the positions of these cleavages are known, the residues of insulin…”
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Design, structure-activity, and molecular modeling studies of potent renin inhibitory peptides having N-terminal Nin-For-Trp (Ftr): angiotensinogen congeners modified by P1-P1' Phe-Phe, Sta, Leu.psi.[CH(OH)CH2]Val or Leu.psi.[CH2NH]Val substitutions by Sawyer, Tomi K, Pals, Donald T, Mao, Boryeu, Staples, Douglas J, DeVaux, Anne E, Maggiora, Linda L, Affholter, Joseph A, Kati, Warren, Duchamp, David

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Structure-activity relationships of [Nle4, D-Phe7]alpha-MSH. Discovery of a tripeptidyl agonist exhibiting sustained bioactivity by Sawyer, T K, Castrucci, A M, Staples, D J, Affholter, J A, De Vaux, A, Hruby, V J, Hadley, M E

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Oligoclonal T-receptor (V beta) use in the response to connective tissue antigens by synovial fluid T-cells from rheumatoid arthritis patients by Wooley, P H, Cuesta, I A, Sud, S, Song, Z, Affholter, J A, Karvonen, R L, Fernández-Madrid, F

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