Search Results - "Af Hallstrom, TM"

Clonal heterogeneity influences drug responsiveness in renal cancer assessed by ex vivo drug testing of multiple patient‐derived cancer cells by Saeed, Khalid, Ojamies, Poojitha, Pellinen, Teijo, Eldfors, Samuli, Turkki, Riku, Lundin, Johan, Järvinen, Petrus, Nisen, Harry, Taari, Kimmo, af Hällström, Taija M., Rannikko, Antti, Mirtti, Tuomas, Kallioniemi, Olli, Östling, Päivi

“…Renal cell cancer (RCC) has become a prototype example of the extensive intratumor heterogeneity and clonal evolution of human cancers. However, there is…”
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KeepEX, a simple dilution protocol for improving extracellular vesicle yields from urine by Puhka, M., Nordberg, M-E., Valkonen, S., Rannikko, A., Kallioniemi, O., Siljander, P., af Hällström, T.M.

“…Urinary extracellular vesicles (EVs) are a promising source of biomarkers, which can be obtained in a non-invasive manner. However, the yield of EVs from urine…”
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Metabolomic Profiling of Extracellular Vesicles and Alternative Normalization Methods Reveal Enriched Metabolites and Strategies to Study Prostate Cancer-Related Changes by Puhka, Maija, Takatalo, Maarit, Nordberg, Maria-Elisa, Valkonen, Sami, Nandania, Jatin, Aatonen, Maria, Yliperttula, Marjo, Laitinen, Saara, Velagapudi, Vidya, Mirtti, Tuomas, Kallioniemi, Olli, Rannikko, Antti, Siljander, Pia R-M, Af Hällström, Taija Maria

“…Body fluids are a rich source of extracellular vesicles (EVs), which carry cargo derived from the secreting cells. So far, biomarkers for pathological…”
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Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer by Saeed, Khalid, Rahkama, Vesa, Eldfors, Samuli, Bychkov, Dmitry, Mpindi, John Patrick, Yadav, Bhagwan, Paavolainen, Lassi, Aittokallio, Tero, Heckman, Caroline, Wennerberg, Krister, Peehl, Donna M, Horvath, Peter, Mirtti, Tuomas, Rannikko, Antti, Kallioniemi, Olli, Östling, Päivi, af Hällström, Taija M

“…Abstract Background Technology development to enable the culture of human prostate cancer (PCa) progenitor cells is required for the identification of new,…”
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Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras‐driven lung tumours by Närhi, Katja, Nagaraj, Ashwini S, Parri, Elina, Turkki, Riku, van Duijn, Petra W, Hemmes, Annabrita, Lahtela, Jenni, Uotinen, Virva, Mäyränpää, Mikko I, Salmenkivi, Kaisa, Räsänen, Jari, Linder, Nina, Trapman, Jan, Rannikko, Antti, Kallioniemi, Olli, Af Hällström, Taija M, Lundin, Johan, Sommergruber, Wolfgang, Anders, Simon, Verschuren, Emmy W

“…A key question in precision medicine is how functional heterogeneity in solid tumours informs therapeutic sensitivity. We demonstrate that spatial…”
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Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras‐driven lung tumours by Narhi, K, Nagaraj, AS, Parri, E, Turkki, R, van Duijn, PW, Hemmes, A, Lahtela, J, Uotinen, V, Mayranpaa, MI, Salmenkivi, K, Rasanen, J, Linder, N, Trapman, J, Rannikko, A, Kallioniemi, O, Af Hallstrom, TM, Lundin, J, Sommergruber, W, Anders, S, Verschuren, EW

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Precision systems medicine in urological Tumors – Molecular profiling and functional testing by Saeed, K., Ojamies, P., Pellinen, T., Rahkama, V., Eldfors, S., Paavolainen, L., Turkki, R., Horvath, P., Lundin, J., Nisen, H., af Hällström, T.M., Rannikko, A., Mirtti, T., Kallioniemi, O., Östling, P.

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DNA Damage Recognition via Activated ATM and p53 Pathway in Nonproliferating Human Prostate Tissue by JÄÄMAA, Sari, AF HÄLLSTRÖM, Taija M, RUUTU, Mirja, ANDERSSON, Leif C, LAIHO, Marikki, SANKILA, Anna, RANTANEN, Ville, KOISTINEN, Hannu, STENMAN, Ulf-Håkan, ZHEWEI ZHANG, ZHIMING YANG, DE MARZO, Angelo M, TAARI, Kimmo

“…DNA damage response (DDR) pathways have been extensively studied in cancer cell lines and mouse models, but little is known about how DNA damage is recognized…”
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Circulating tumor DNA in early‐stage breast cancer: personalized biomarkers for occult metastatic disease and risk of relapse? by af Hällström, Taija M, Puhka, Maija, Kallioniemi, Olli

“…The availability of blood‐based markers to predict response of a solid tumor to treatment, estimate patient prognosis and diagnose relapse well before clinical…”
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