Search Results - "Aeschimann, Walter"
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Self-assembled α-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier
Published in Scientific reports (10-07-2017)“…Vitamin E is one of the most important natural antioxidants, protecting polyunsaturated fatty acids in the membranes of cells. Among different chemical…”
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Engineering of a functional γ-tocopherol transfer protein
Published in Redox biology (01-01-2021)“…α-tocopherol transfer protein (TTP) was previously reported to self-aggregate into 24-meric spheres (α-TTPS) and to possess transcytotic potency across…”
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Engineering tocopherol selectivity in α-TTP: a combined in vitro/in silico study
Published in PloS one (13-11-2012)“…We present a combined in vitro/in silico study to determine the molecular origin of the selectivity of [Formula: see text]-tocopherol transfer protein…”
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Mechanisms of Ligand-Protein Interaction in Sec-14-like Transporters Investigated by Computer Simulations
Published in Chimia (01-09-2014)“…We review our recent work on protein-ligand interactions in vitamin transporters of the Sec-14-like protein. Our studies focused on the cellular-retinaldehyde…”
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Structural insights on cholesterol endosynthesis: Binding of squalene and 2,3-oxidosqualene to supernatant protein factor
Published in Journal of structural biology (01-06-2015)“…We present the crystal structures of the SEC14-like domain of supernatant protein factor (SPF) in complex with squalene and 2,3-oxidosqualene. The structures…”
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Structural insight into DNA-assembled oligochromophores: crystallographic analysis of pyrene- and phenanthrene-modified DNA in complex with BpuJI endonuclease
Published in Nucleic acids research (06-09-2016)“…The use of the DNA duplex as a supramolecular scaffold is an established approach for the assembly of chromophore aggregates. In the absence of detailed…”
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Engineering Tocopherol Selectivity in [alpha]-TTP: A Combined In Vitro/In Silico Study
Published in PloS one (13-11-2012)“…We present a combined in vitro/in silico study to determine the molecular origin of the selectivity of -tocopherol transfer protein (-TTP) towards -tocopherol…”
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