Search Results - "Aeschimann, Florian"

Autoregulation of the nonsense-mediated mRNA decay pathway in human cells by Yepiskoposyan, Hasmik, Aeschimann, Florian, Nilsson, Daniel, Okoniewski, Michal, Mühlemann, Oliver

“…Nonsense-mediated mRNA decay (NMD) is traditionally portrayed as a quality-control mechanism that degrades mRNAs with truncated open reading frames (ORFs)…”
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A branched heterochronic pathway directs juvenile-to-adult transition through two LIN-29 isoforms by Azzi, Chiara, Aeschimann, Florian, Neagu, Anca, Großhans, Helge

“…Robust organismal development relies on temporal coordination of disparate physiological processes. In , the heterochronic pathway controls a timely…”
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The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan by Mittal, Nitish, Guimaraes, Joao C., Gross, Thomas, Schmidt, Alexander, Vina-Vilaseca, Arnau, Nedialkova, Danny D., Aeschimann, Florian, Leidel, Sebastian A., Spang, Anne, Zavolan, Mihaela

“…In Saccharomyces cerevisiae , deletion of large ribosomal subunit protein-encoding genes increases the replicative lifespan in a Gcn4-dependent manner…”
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Timing mechanism of sexually dimorphic nervous system differentiation by Pereira, Laura, Aeschimann, Florian, Wang, Chen, Lawson, Hannah, Serrano-Saiz, Esther, Portman, Douglas S, Großhans, Helge, Hobert, Oliver

“…The molecular mechanisms that control the timing of sexual differentiation in the brain are poorly understood. We found that the timing of sexually dimorphic…”
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The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing by Stalder, Lukas, Heusermann, Wolf, Sokol, Lena, Trojer, Dominic, Wirz, Joel, Hean, Justin, Fritzsche, Anja, Aeschimann, Florian, Pfanzagl, Vera, Basselet, Pascal, Weiler, Jan, Hintersteiner, Martin, Morrissey, David V, Meisner-Kober, Nicole C

“…Despite progress in mechanistic understanding of the RNA interference (RNAi) pathways, the subcellular sites of RNA silencing remain under debate. Here we show…”
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LSM2-8 and XRN-2 contribute to the silencing of H3K27me3-marked genes through targeted RNA decay by Mattout, Anna, Gaidatzis, Dimos, Padeken, Jan, Schmid, Christoph D., Aeschimann, Florian, Kalck, Véronique, Gasser, Susan M.

“…In fission yeast and plants, RNA processing and degradation contribute to heterochromatin silencing, alongside conserved pathways of transcriptional…”
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Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition by Kumari, Pooja, Aeschimann, Florian, Gaidatzis, Dimos, Keusch, Jeremy J., Ghosh, Pritha, Neagu, Anca, Pachulska-Wieczorek, Katarzyna, Bujnicki, Janusz M., Gut, Heinz, Großhans, Helge, Ciosk, Rafal

“…RNA-binding proteins regulate all aspects of RNA metabolism. Their association with RNA is mediated by RNA-binding domains, of which many remain…”
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Extensive Oscillatory Gene Expression during C. elegans Larval Development by Hendriks, Gert-Jan, Gaidatzis, Dimos, Aeschimann, Florian, Großhans, Helge

“…Oscillations are a key to achieving dynamic behavior and thus occur in biological systems as diverse as the beating heart, defecating worms, and nascent…”
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LIN41 Post-transcriptionally Silences mRNAs by Two Distinct and Position-Dependent Mechanisms by Aeschimann, Florian, Kumari, Pooja, Bartake, Hrishikesh, Gaidatzis, Dimos, Xu, Lan, Ciosk, Rafal, Großhans, Helge

“…The RNA-binding protein (RBP) LIN41, also known as LIN-41 or TRIM71, is a key regulator of animal development, but its physiological targets and molecular…”
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Bayesian prediction of RNA translation from ribosome profiling by Malone, Brandon, Atanassov, Ilian, Aeschimann, Florian, Li, Xinping, Großhans, Helge, Dieterich, Christoph

“…Ribosome profiling via high-throughput sequencing (ribo-seq) is a promising new technique for characterizing the occupancy of ribosomes on messenger RNA (mRNA)…”
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An optimized protocol for quality control of gene therapy vectors using nanopore direct RNA sequencing by Zeglinski, Kathleen, Montellese, Christian, Ritchie, Matthew E, Alhamdoosh, Monther, Vonarburg, Cédric, Bowden, Rory, Jordi, Monika, Gouil, Quentin, Aeschimann, Florian, Hsu, Arthur

“…Despite recent advances made toward improving the efficacy of lentiviral gene therapies, a sizeable proportion of produced vector contains an incomplete and…”
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Transcriptome-wide measurement of ribosomal occupancy by ribosome profiling by Aeschimann, Florian, Xiong, Jieyi, Arnold, Andreas, Dieterich, Christoph, Großhans, Helge

“…•Detailed protocol for ribosome profiling experiments in model organisms.•Presentation of bioinformatic strategies to evaluate ribosome profiling…”
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let-7 coordinates the transition to adulthood through a single primary and four secondary targets by Aeschimann, Florian, Neagu, Anca, Rausch, Magdalene, Großhans, Helge

“…The juvenile-to-adult (J/A) transition, or puberty, is a period of extensive changes of animal body morphology and function. The onset of puberty is…”
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Structural basis of siRNA recognition by TRBP double‐stranded RNA binding domains by Masliah, Gregoire, Maris, Christophe, König, Sebastian LB, Yulikov, Maxim, Aeschimann, Florian, Malinowska, Anna L, Mabille, Julie, Weiler, Jan, Holla, Andrea, Hunziker, Juerg, Meisner‐Kober, Nicole, Schuler, Benjamin, Jeschke, Gunnar, Allain, Frederic H‐T

“…The accurate cleavage of pre‐micro(mi)RNAs by Dicer and mi/siRNA guide strand selection are important steps in forming the RNA‐induced silencing complex…”
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DNA-PK inhibition enhances gene editing efficiency in HSPCs for CRISPR-based treatment of X-linked hyper IgM syndrome by Pugliano, Cole M., Berger, Mason, Ray, Roslyn M., Sapkos, Kai, Wu, Betty, Laird, Aidan, Ye, Yidian, Thomson, Daniel, DeGottardi, M. Quinn, Khan, Iram F., Tatiossian, Kristina, Miles, Brodie A., Aeschimann, Florian, Pasquier, Jerome, Kim, Mihee M., Rawlings, David J.

“…Targeted gene editing to restore CD40L expression via homology-directed repair (HDR) in CD34+ hematopoietic stem and progenitor cells (HSPCs) represents a…”
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RNA specificity of NHL domains revisited: LIN-41/TRIM71 binds a defined RNA stem-loop element via shape and electrostatic complementarity by Gut, Heinz, Kumari, Pooja, Aeschimann, Florian, Gaidatzis, Dimos, Keusch, Jeremy J., Neagu, Anca, Pachulska-Wieczorek, Katarzyna, Grosshans, Helge, Ciosk, Rafal

“…Abstract only…”
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Structural basis of si RNA recognition by TRBP double‐stranded RNA binding domains by Masliah, Gregoire, Maris, Christophe, König, Sebastian LB, Yulikov, Maxim, Aeschimann, Florian, Malinowska, Anna L, Mabille, Julie, Weiler, Jan, Holla, Andrea, Hunziker, Juerg, Meisner‐Kober, Nicole, Schuler, Benjamin, Jeschke, Gunnar, Allain, Frederic H‐T

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