Search Results - "Aehle, W."

Zooming In on Metagenomics: Molecular Microdiversity of Subtilisin Carlsberg in Soil by Gabor, E., Niehaus, F., Aehle, W., Eck, J.

“…Evolution has led to the development of a gigantic repertoire of microbial genes that can be exploited for industrial purposes. Due to microevolutionary…”
Get full text

Construction of stabilized proteins by combinatorial consensus mutagenesis by Amin, N., Liu, A.D., Ramer, S., Aehle, W., Meijer, D., Metin, M., Wong, S., Gualfetti, P., Schellenberger, V.

“…We constructed stabilized variants of β-lactamase (BLA) from Enterobacter cloacae by combinatorial recruitment of consensus mutations. By aligning the…”
Get full text

Wege zur effizienten Erschließung des Metagenoms by Aehle, W., Eck, J.

Get full text

Rational protein engineering and industrial application: structure prediction by homology and rational design of protein-variants with improved 'washing performance'--the alkaline protease from Bacillus alcalophilus by Aehle, W, Sobek, H, Amory, A, Vetter, R, Wilke, D, Schomburg, D

“…The successful attempt is presented to engineer an enzyme with respect to its technical application by the use of computer-aided protein design techniques…”
Get more information

Buchbesprechung: Artificial Enzymes. Von R. Breslow by Aehle, W.

Get full text

X-ray structure determination and comparison of two crystal forms of a variant (Asn115Arg) of the alkaline protease from Bacillus alcalophilus refined at 1.85 A resolution by Sobek, H, Hecht, H J, Aehle, W, Schomburg, D

“…The X-ray structure determination, refinement and comparison of two crystal forms of a variant (Asn115Arg) of the alkaline protease from Bacillus alcalophilus…”
Get more information

Crystal structure of an alkaline protease from Bacillus alcalophilus at 2.4 Å resolution by SOBEK, H, HECHT, H. J, HOFMANN, B, AEHLE, W, SCHOMBURG, D

“…The crystal structure of an alkaline protease from Bacillus alcalophilus has been determined by X-ray diffraction at 2.4 A resolution. The enzyme crystallizes…”
Get full text

A β-lactamase with reduced immunogenicity for the targeted delivery of chemotherapeutics using antibody-directed enzyme prodrug therapy by Harding, Fiona A, Liu, Amy D, Stickler, Marcia, Razo, O Jennifer, Chin, Regina, Faravashi, Nargol, Viola, Wendy, Graycar, Tom, Yeung, V Pete, Aehle, Wolfgang, Meijer, Daan, Wong, Stephanie, Rashid, M Harunur, Valdes, Ana M, Schellenberger, Volker

“…Antibody-directed enzyme prodrug therapy (ADEPT) delivers chemotherapeutic agents in high concentration to tumor tissue while minimizing systemic drug…”
Get full text

Wege zur effizienten Erschließung des Metagenoms by Aehle, W., Eck, J.

Get full text

Buchbesprechung: Artificial Enzymes. Von R. Breslow by Aehle, W.

Get full text

The three-dimensional structure of an intact glucoamylase by Bott, R., Saldajeno, M., Cuevas, B., Ward, D., Scheffers, M., Aehle, W., Sandgren, M., Hansson, H.

“…Abstract only…”
Get full text

Evaluation of protein 3-D structure prediction: Comparison of modelled and X-ray structure of an alkaline serine protease by Aehle, Wolfgang, Sobek, Harald, Schomburg, Dietmar

“…We describe the modelling of the structure of the highly alkaline subtilisin protease OPTICLEAN from Bacillus alcalophilus. The model was developed through…”
Get full text

Crystal structure of an alkaline protease from Bacillus alcalophilus at 2.4Åresolution by Sobek, H., Hecht, H.J., Hofmann, B., Aehle, W., Schomburg, D.

“…The crystal structure of an alkaline protease from Bacillus alcahphilus has been determined by X-ray diffraction at 2.4Åresolution. The enzyme crystallizes in…”
Get full text

Crystal structure of an alkaline protease from Bacillus alcalophilus at 2.4 angstroms resolution by Sobek, H, Hecht, HJ, Hofmann, B, Aehle, W, Schomburg, D

“…The crystal structure of an alkaline protease from Bacillus alcalophilus has been determined by X-ray diffraction at 2.4 angstroms resolution. The enzyme…”
Get full text

Structure/activity relationship of adenine‐modified NAD derivatives with respect to porcine heart lactate dehydrogenase isozyme H 4 simulated with molecular mechanics by HENDLE, Jörg, BÜCKMANN, Andreas F., AEHLE, Wolfgang, SCHOMBURG, Dietmar, SCHMID, Rolf D.

“…Using a significantly simplifed modification procedure, four charged analogues of the coenzyme NAD, N (1)‐ and N 6 ‐(2‐hydroxy‐3‐trimethylammoniumpropyl)‐NAD,…”
Get full text

Structure/activity relationship of adenine‐modified NAD derivatives with respect to porcine heart lactate dehydrogenase isozyme H4 simulated with molecular mechanics by HENDLE, Jörg, BÜCKMANN, Andreas F., AEHLE, Wolfgang, SCHOMBURG, Dietmar, SCHMID, Rolf D.

“…Using a significantly simplifed modification procedure, four charged analogues of the coenzyme NAD, N(1)‐ and N6‐(2‐hydroxy‐3‐trimethylammoniumpropyl)‐NAD,…”
Get full text