Search Results - "Aebersold, Ruedi"

Mass-spectrometric exploration of proteome structure and function by Aebersold, Ruedi, Mann, Matthias

“…Numerous biological processes are concurrently and coordinately active in every living cell. Each of them encompasses synthetic, catalytic and regulatory…”
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Proteomic and interactomic insights into the molecular basis of cell functional diversity by Bludau, Isabell, Aebersold, Ruedi

“…The ability of living systems to adapt to changing conditions originates from their capacity to change their molecular constitution. This is achieved by…”
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Selected reaction monitoring–based proteomics: workflows, potential, pitfalls and future directions by Picotti, Paola, Aebersold, Ruedi

“…In this Review, the authors provide a guide through to the different steps involved in selected reaction monitoring as well as discuss its applications…”
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On the Dependency of Cellular Protein Levels on mRNA Abundance by Liu, Yansheng, Beyer, Andreas, Aebersold, Ruedi

“…The question of how genomic information is expressed to determine phenotypes is of central importance for basic and translational life science research and has…”
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Lysine-specific chemical cross-linking of protein complexes and identification of cross-linking sites using LC-MS/MS and the xQuest/xProphet software pipeline by Leitner, Alexander, Walzthoeni, Thomas, Aebersold, Ruedi

“…Chemical cross-linking in combination with LC-MS/MS (XL-MS) is an emerging technology to obtain low-resolution structural (distance) restraints of proteins and…”
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Options and considerations when selecting a quantitative proteomics strategy by Domon, Bruno, Aebersold, Ruedi

“…The vast majority of proteomic studies to date have relied on mass spectrometric techniques to identify, and in some cases quantify, peptides that have been…”
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Crosslinking and Mass Spectrometry: An Integrated Technology to Understand the Structure and Function of Molecular Machines by Leitner, Alexander, Faini, Marco, Stengel, Florian, Aebersold, Ruedi

“…In recent years, chemical crosslinking of protein complexes and the identification of crosslinked residues by mass spectrometry (XL-MS; sometimes abbreviated…”
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Applying mass spectrometry-based proteomics to genetics, genomics and network biology by Gstaiger, Matthias, Aebersold, Ruedi

“…Key Points Mass spectrometry-based proteomics is the only method currently available to comprehensively analyse changes in mutant proteomes. Several…”
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Mass Spectrometry and Protein Analysis by Domon, Bruno, Aebersold, Ruedi

“…Mass spectrometry is a central analytical technique for protein research and for the study of biomolecules in general. Driven by the need to identify,…”
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Data‐independent acquisition‐based SWATH‐MS for quantitative proteomics: a tutorial by Ludwig, Christina, Gillet, Ludovic, Rosenberger, George, Amon, Sabine, Collins, Ben C, Aebersold, Ruedi

“…Many research questions in fields such as personalized medicine, drug screens or systems biology depend on obtaining consistent and quantitatively accurate…”
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diaPASEF: parallel accumulation–serial fragmentation combined with data-independent acquisition by Meier, Florian, Brunner, Andreas-David, Frank, Max, Ha, Annie, Bludau, Isabell, Voytik, Eugenia, Kaspar-Schoenefeld, Stephanie, Lubeck, Markus, Raether, Oliver, Bache, Nicolai, Aebersold, Ruedi, Collins, Ben C., Röst, Hannes L., Mann, Matthias

“…Data-independent acquisition modes isolate and concurrently fragment populations of different precursors by cycling through segments of a predefined precursor…”
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Selected reaction monitoring for quantitative proteomics: a tutorial by Aebersold, Ruedi, Lange, Vinzenz, Domon, Bruno, Picotti, Paola

“…Systems biology relies on data sets in which the same group of proteins is consistently identified and precisely quantified across multiple samples, a…”
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JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications by Kasinath, Vignesh, Beck, Curtis, Sauer, Paul, Poepsel, Simon, Kosmatka, Jennifer, Faini, Marco, Toso, Daniel, Aebersold, Ruedi, Nogales, Eva

“…Polycomb repressive complexes 1 and 2 (PRC1 and PRC2) cooperate to determine cell identity by epigenetic gene expression regulation. However, the mechanism of…”
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Mass Spectrometry Applied to Bottom-Up Proteomics: Entering the High-Throughput Era for Hypothesis Testing by Gillet, Ludovic C, Leitner, Alexander, Aebersold, Ruedi

“…Proteins constitute a key class of molecular components that perform essential biochemical reactions in living cells. Whether the aim is to extensively…”
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Architecture and conformational switch mechanism of the ryanodine receptor by Efremov, Rouslan G., Leitner, Alexander, Aebersold, Ruedi, Raunser, Stefan

“…Muscle contraction is initiated by the release of calcium (Ca 2+ ) from the sarcoplasmic reticulum into the cytoplasm of myocytes through ryanodine receptors…”
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Quantitative Analysis of Fission Yeast Transcriptomes and Proteomes in Proliferating and Quiescent Cells by Marguerat, Samuel, Schmidt, Alexander, Codlin, Sandra, Chen, Wei, Aebersold, Ruedi, Bähler, Jürg

“…Data on absolute molecule numbers will empower the modeling, understanding, and comparison of cellular functions and biological systems. We quantified…”
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Targeted Data Extraction of the MS/MS Spectra Generated by Data-independent Acquisition: A New Concept for Consistent and Accurate Proteome Analysis by Gillet, Ludovic C., Navarro, Pedro, Tate, Stephen, Röst, Hannes, Selevsek, Nathalie, Reiter, Lukas, Bonner, Ron, Aebersold, Ruedi

“…Most proteomic studies use liquid chromatography coupled to tandem mass spectrometry to identify and quantify the peptides generated by the proteolysis of a…”
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ChromID identifies the protein interactome at chromatin marks by Villaseñor, Rodrigo, Pfaendler, Ramon, Ambrosi, Christina, Butz, Stefan, Giuliani, Sara, Bryan, Elana, Sheahan, Thomas W., Gable, Annika L., Schmolka, Nina, Manzo, Massimiliano, Wirz, Joël, Feller, Christian, von Mering, Christian, Aebersold, Ruedi, Voigt, Philipp, Baubec, Tuncay

“…Chromatin modifications regulate genome function by recruiting proteins to the genome. However, the protein composition at distinct chromatin modifications has…”
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Structures of human PRC2 with its cofactors AEBP2 and JARID2 by Kasinath, Vignesh, Faini, Marco, Poepsel, Simon, Reif, Dvir, Feng, Xinyu Ashlee, Stjepanovic, Goran, Aebersold, Ruedi, Nogales, Eva

“…Transcriptionally repressive histone H3 lysine 27 methylation by Polycomb repressive complex 2 (PRC2) is essential for cellular differentiation and…”
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NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice by Zhang, Hongbo, Ryu, Dongryeol, Wu, Yibo, Gariani, Karim, Wang, Xu, Luan, Peiling, D'Amico, Davide, Ropelle, Eduardo R., Lutolf, Matthias P., Aebersold, Ruedi, Schoonjans, Kristina, Menzies, Keir J., Auwerx, Johan

“…Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to senescence during aging. We demonstrate the importance of…”
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