Search Results - "Advani, Sunil J."

Monomethyl auristatin antibody and peptide drug conjugates for trimodal cancer chemo-radio-immunotherapy by Hingorani, Dina V., Allevato, Michael M., Camargo, Maria F., Lesperance, Jacqueline, Quraishi, Maryam A., Aguilera, Joseph, Franiak-Pietryga, Ida, Scanderbeg, Daniel J., Wang, Zhiyong, Molinolo, Alfredo A., Alvarado, Diego, Sharabi, Andrew B., Bui, Jack D., Cohen, Ezra E. W., Adams, Stephen R., Gutkind, J. Silvio, Advani, Sunil J.

“…Locally advanced cancers remain therapeutically challenging to eradicate. The most successful treatments continue to combine decades old non-targeted…”
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A FZD7-specific Antibody-Drug Conjugate Induces Ovarian Tumor Regression in Preclinical Models by Do, Myan, Wu, Christina C N, Sonavane, Pooja R, Juarez, Edwin F, Adams, Stephen R, Ross, Jason, Rodriguez Y Baena, Alessandra, Patel, Charmi, Mesirov, Jill P, Carson, Dennis A, Advani, Sunil J, Willert, Karl

“…Although WNT signaling is frequently dysregulated in solid tumors, drugging this pathway has been challenging due to off-tumor effects. Current clinical…”
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MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment by Wilson, RaeAnna, Espinosa-Diez, Cristina, Kanner, Nathan, Chatterjee, Namita, Ruhl, Rebecca, Hipfinger, Christina, Advani, Sunil J., Li, Jie, Khan, Omar F., Franovic, Aleksandra, Weis, Sara M., Kumar, Sushil, Coussens, Lisa M., Anderson, Daniel G., Chen, Clark C., Cheresh, David A., Anand, Sudarshan

“…Rather than targeting tumour cells directly, elements of the tumour microenvironment can be modulated to sensitize tumours to the effects of therapy. Here we…”
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Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize by Adams, Stephen R., Yang, Howard C., Savariar, Elamprakash N., Aguilera, Joe, Crisp, Jessica L., Jones, Karra A., Whitney, Michael A., Lippman, Scott M., Cohen, Ezra E. W., Tsien, Roger Y., Advani, Sunil J.

“…Tumour resistance to radiotherapy remains a barrier to improving cancer patient outcomes. To overcome radioresistance, certain drugs have been found to…”
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Tumor Activated Cell Penetrating Peptides to Selectively Deliver Immune Modulatory Drugs by Hingorani, Dina V, Camargo, Maria F, Quraishi, Maryam A, Adams, Stephen R, Advani, Sunil J

“…Recent advances in immunotherapy have revolutionized cancer therapy. Immunotherapies can engage the adaptive and innate arms of the immune system. Therapeutics…”
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ReVOLT: radiation-enhanced viral oncolytic therapy by Advani, Sunil J, Mezhir, James J, Roizman, Bernard, Weichselbaum, Ralph R

“…Viral oncolytic therapy has been pursued with renewed interest as the molecular basis of carcinogenesis and viral replication has been elucidated. Genetically…”
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Phase I Trial of Intravenous Oncolytic Vaccinia Virus (GL-ONC1) with Cisplatin and Radiotherapy in Patients with Locoregionally Advanced Head and Neck Carcinoma by Mell, Loren K, Brumund, Kevin T, Daniels, Gregory A, Advani, Sunil J, Zakeri, Kaveh, Wright, Mary E, Onyeama, Sara-Jane, Weisman, Robert A, Sanghvi, Parag R, Martin, Peter J, Szalay, Aladar A

“…Preclinical models have shown that the effectiveness of GL-ONC1, a modified oncolytic vaccinia virus, is enhanced by radiation and chemotherapy. The purpose of…”
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The Carboxyl-Terminal Domain of RNA Polymerase II Is Phosphorylated by a Complex Containing cdk9 and Infected-Cell Protein 22 of Herpes Simplex Virus 1 by DURAND, Lizette O, ADVANI, Sunil J, POON, Alice P. W, ROIZMAN, Bernard

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Enhancing Radiotherapy With Genetically Engineered Viruses by Advani, Sunil J, Weichselbaum, Ralph R, Chmura, Steven J

“…Concurrent radiotherapy and chemotherapy have been used to treat a variety of tumors to improve local control and overall survival. Gene therapy strategies…”
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Establishment of Patient-Derived Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumor Models for Predicting Therapeutic Response by Yebra, Mayra, Bhargava, Shruti, Kumar, Avi, Burgoyne, Adam M, Tang, Chih-Min, Yoon, Hyunho, Banerjee, Sudeep, Aguilera, Joseph, Cordes, Thekla, Sheth, Vipul, Noh, Sangkyu, Ustoy, Rowan, Li, Sam, Advani, Sunil J, Corless, Christopher L, Heinrich, Michael C, Kurzrock, Razelle, Lippman, Scott M, Fanta, Paul T, Harismendy, Olivier, Metallo, Christian, Sicklick, Jason K

“…Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the gastrointestinal tract, with mutant succinate dehydrogenase ( ) subunits (A-D)…”
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Herpes Simplex Virus 1 Activates cdc2 to Recruit Topoisomerase IIα for Post-DNA Synthesis Expression of Late Genes by Advani, Sunil J., Weichselbaum, Ralph R., Roizman, Bernard

“…A subset (γ2) of late herpes simplex virus 1 genes depends on viral DNA synthesis for its expression. For optimal expression, a small number of these genes,…”
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Precision Chemoradiotherapy for HER2 Tumors Using Antibody Conjugates of an Auristatin Derivative with Reduced Cell Permeability by Hingorani, Dina V, Doan, Matthew K, Camargo, Maria F, Aguilera, Joseph, Song, Seung M, Pizzo, Donald, Scanderbeg, Daniel J, Cohen, Ezra E W, Lowy, Andrew M, Adams, Stephen R, Advani, Sunil J

“…The most successful therapeutic strategies for locally advanced cancers continue to combine decades-old classical radiosensitizing chemotherapies with…”
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Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery by Buckel, Lisa, Savariar, Elamprakash N, Crisp, Jessica L, Jones, Karra A, Hicks, Angel M, Scanderbeg, Daniel J, Nguyen, Quyen T, Sicklick, Jason K, Lowy, Andrew M, Tsien, Roger Y, Advani, Sunil J

“…Intrinsic tumor resistance to radiotherapy limits the efficacy of ionizing radiation (IR). Sensitizing cancer cells specifically to IR would improve tumor…”
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Kinase-independent role for CRAF-driving tumour radioresistance via CHK2 by Advani, Sunil J., Camargo, Maria Fernanda, Seguin, Laetitia, Mielgo, Ainhoa, Anand, Sudarshan, Hicks, Angel M., Aguilera, Joseph, Franovic, Aleksandra, Weis, Sara M., Cheresh, David A.

“…Although oncology therapy regimens commonly include radiation and genotoxic drugs, tumour cells typically develop resistance to these interventions. Here we…”
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Redirecting extracellular proteases to molecularly guide radiosensitizing drugs to tumors by Hingorani, Dina V., Crisp, Jessica L., Doan, Matthew K., Camargo, Maria F., Quraishi, Maryam A., Aguilera, Joseph, Gilardi, Mara, Gross, Larry A., Jiang, Tao, Li, Wei T., Ongkeko, Weg M., Cohen, Ezra E.W., Gutkind, J. Silvio, Adams, Stephen R., Advani, Sunil J.

“…Patients with advanced cancers are treated with combined radiotherapy and chemotherapy, however curability is poor and treatment side effects severe. Drugs…”
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The Role of cdc2 in the Expression of Herpes Simplex Virus Genes by Advani, Sunil J., Weichselbaum, Ralph R., Roizman, Bernard

“…Earlier reports have shown that cdc2 kinase is activated in cells infected with herpes simplex virus 1 and that the activation is mediated principally by two…”
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Radiation-Drug Combinations to Improve Clinical Outcomes and Reduce Normal Tissue Toxicities: Current Challenges and New Approaches: Report of the Symposium Held at the 63rd Annual Meeting of the Radiation Research Society, 15–18 October 2017; Cancun, Mexico by Falls, Kelly C., Sharma, Ricky A., Lawrence, Yaacov R., Amos, Richard A., Advani, Sunil J., Ahmed, Mansoor M., Vikram, Bhadrasain, Coleman, C. Norman, Prasanna, Pataje G.

“…The National Cancer Institute's (NCI) Radiation Research Program (RRP) is endeavoring to increase the relevance of preclinical research to improve outcomes of…”
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A MEK-independent role for CRAF in mitosis and tumor progression by Mielgo, Ainhoa, Seguin, Laetitia, Huang, Miller, Camargo, Maria Fernanda, Anand, Sudarshan, Franovic, Aleksandra, Weis, Sara M, Advani, Sunil J, Murphy, Eric A, Cheresh, David A

“…Raf kinase activity is deregulated in cancers and is thought to promote tumor growth by inducing proliferation signaling through MEK/Erk. This report…”
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An in vitro study for the dosimetric and radiobiological validation of respiratory gating in conventional and hypofractionated radiotherapy of the lung: effect of dose, dose rate, and breathing pattern by Cerviño, Laura I, Soultan, Dima, Advani, Sunil J, Cornell, Mariel, Yock, Adam, Pettersson, Niclas, Song, William Y, Aguilera, Joseph, Murphy, James, Hoh, Carl, James, Claude, Paravati, Anthony, Coope, Robin, Gill, Bradford, Moiseenko, Vitali

“…Stereotactic body radiotherapy (SBRT) of the lung has become a standard of care for early-stage inoperable non-small cell lung cancer (NSCLC). A common…”
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Combination of fractionated irradiation with anti‐VEGF expressing vaccinia virus therapy enhances tumor control by simultaneous radiosensitization of tumor associated endothelium by Buckel, Lisa, Advani, Sunil J., Frentzen, Alexa, Zhang, Qian, Yu, Yong A., Chen, Nanhai G., Ehrig, Klaas, Stritzker, Jochen, Mundt, Arno J., Szalay, Aladar A.

“…Oncolytic viruses are currently in clinical trials for a variety of tumors, including high grade gliomas. A characteristic feature of high grade gliomas is…”
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