Search Results - "Adrian Erlebacher"

Immunology of the Maternal-Fetal Interface by Erlebacher, Adrian

“…The immune cells that reside at the interface between the placenta and uterus are thought to play many important roles in pregnancy. Recent work has revealed…”
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Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils by Mahiddine, Karim, Blaisdell, Adam, Ma, Stephany, Créquer-Grandhomme, Amandine, Lowell, Clifford A, Erlebacher, Adrian

“…Polymorphonuclear neutrophils (PMNs) are increasingly recognized to influence solid tumor development, but why their effects are so context dependent and even…”
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Immune mechanisms at the maternal-fetal interface: perspectives and challenges by PrabhuDas, Mercy, Bonney, Elizabeth, Caron, Kathleen, Dey, Sudhansu, Erlebacher, Adrian, Fazleabas, Asgerally, Fisher, Susan, Golos, Thaddeus, Matzuk, Martin, McCune, Joseph M, Mor, Gil, Schulz, Laura, Soares, Michael, Spencer, Thomas, Strominger, Jack, Way, Sing Sing, Yoshinaga, Koji

“…Leaders gathered at the US National Institutes of Health in November 2014 to discuss recent advances and emerging research areas in aspects of maternal-fetal…”
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Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells by Blaisdell, Adam, Crequer, Amandine, Columbus, Devin, Daikoku, Takiko, Mittal, Khush, Dey, Sudhansu K., Erlebacher, Adrian

“…Polymorphonuclear neutrophils (PMNs) are largely considered to foster cancer development despite wielding an arsenal of cytotoxic agents. Using a mouse model…”
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Dendritic cell entrapment within the pregnant uterus inhibits immune surveillance of the maternal/fetal interface in mice by Collins, Mary K, Tay, Chin-Siean, Erlebacher, Adrian

“…Embryo implantation induces formation of the decidua, a stromal cell-derived structure that encases the fetus and placenta. Using the mouse as a model…”
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Strangers no more: Uterine NK cell recognition of the placenta in mice by Erlebacher, Adrian

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H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition by Nancy, Patrice, Siewiera, Johan, Rizzuto, Gabrielle, Tagliani, Elisa, Osokine, Ivan, Manandhar, Priyanka, Dolgalev, Igor, Clementi, Caterina, Tsirigos, Aristotelis, Erlebacher, Adrian

“…Uncovering the causes of pregnancy complications such as preterm labor requires greater insight into how the uterus remains in a noncontractile state until…”
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Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1 by Tagliani, Elisa, Shi, Chao, Nancy, Patrice, Tay, Chin-Siean, Pamer, Eric G, Erlebacher, Adrian

“…Tissue macrophages (Mφs) and dendritic cells (DCs) play essential roles in tissue homeostasis and immunity. How these cells are maintained at their…”
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miR-30b/30d Regulation of GalNAc Transferases Enhances Invasion and Immunosuppression during Metastasis by Gaziel-Sovran, Avital, Segura, Miguel F., Di Micco, Raffaella, Collins, Mary K., Hanniford, Douglas, Vega-Saenz de Miera, Eleazar, Rakus, John F., Dankert, John F., Shang, Shulian, Kerbel, Robert S., Bhardwaj, Nina, Shao, Yongzhao, Darvishian, Farbod, Zavadil, Jiri, Erlebacher, Adrian, Mahal, Lara K., Osman, Iman, Hernando, Eva

“…To metastasize, a tumor cell must acquire abilities such as the capacity to colonize new tissue and evade immune surveillance. Recent evidence suggests that…”
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Mechanisms of T cell tolerance towards the allogeneic fetus by Erlebacher, Adrian

“…Key Points Recent work in mice has revealed several mechanisms that either minimize the activation of maternal T cells with fetal or placental specificity, or…”
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Cis-acting pathways selectively enforce the non-immunogenicity of shed placental antigen for maternal CD8 T cells by Tay, Chin-Siean, Tagliani, Elisa, Collins, Mary K, Erlebacher, Adrian

“…Maternal immune tolerance towards the fetus and placenta is thought to be established in part by pathways that attenuate T cell priming to antigens released…”
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Trophoblast antigens, fetal blood cell antigens, and the paradox of fetomaternal tolerance by Rizzuto, Gabrielle, Erlebacher, Adrian

“…The paradox of fetomaternal tolerance has puzzled immunologists and reproductive biologists alike for almost 70 yr. Even the idea that the conceptus evokes a…”
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T cell behavior at the maternal-fetal interface by Nancy, Patrice, Erlebacher, Adrian

“…Understanding the function of T cells at the maternal-fetal interface remains one of the most difficult problems in reproductive immunology. A great deal of…”
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Inflammation and Autism: From Maternal Gut to Fetal Brain by Osokine, Ivan, Erlebacher, Adrian

“…Maternal immune activation (MIA) during pregnancy is associated with an increased risk of behavioral disorders in the offspring of affected mothers. Two recent…”
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Differential transcription of Eomes and T-bet during maturation of mouse uterine natural killer cells by Chandrakant Tayade, Yuan Fang, Gordon P. Black, Paffaro VA, Jr, Adrian Erlebacher, B. Anne Croy

“…During human and rodent uterine decidualization, transient but abundant numbers of uterine natural killer (uNK) cells appear, proliferate, and differentiate…”
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Immune surveillance of the maternal/fetal interface: controversies and implications by Erlebacher, Adrian

“…How the fetal ‘allograft’ avoids rejection during pregnancy remains a major unresolved immunological paradox. Recent work has suggested that fetomaternal…”
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Dendritic cell function at the maternal-fetal interface by Tagliani, Elisa, Erlebacher, Adrian

“…Understanding the evolutionary adaptation of the immune system to the developing fetus and placenta represents one of the most fascinating problems in…”
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Chemokine Gene Silencing in Decidual Stromal Cells Limits T Cell Access to the Maternal-Fetal Interface by Nancy, Patrice, Tagliani, Elisa, Tay, Chin-Siean, Asp, Patrik, Levy, David E., Erlebacher, Adrian

“…The chemokine-mediated recruitment of effector T cells to sites of inflammation is a central feature of the immune response. The extent to which chemokine…”
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CD22/Lyn-mediated suppression of trophoblast antigen-specific B cells underlies fetomaternal tolerance by Rizzuto, Gabrielle, Brooks, Jeremy, Fisher, Susan, Zikherman, Julie, Erlebacher, Adrian

“…Abstract The placenta releases allogeneic trophoblast antigens into maternal circulation during pregnancy. Maternal antigen presenting cells present these…”
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Myometrial leukocytes by Siewiera, Johan, Erlebacher, Adrian

“…The myometrium, like all tissues, is home to a cadre of different kinds of leukocytes. As with other tissues, these leukocytes are presumed to contribute not…”
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