Translocation (3;21) in Philadelphia positive chronic myeloid leukemia: high resolution chromosomal analysis and immunological study on five new cases

Translocation t(3;21)(q26;q22) is a rare but nonrandom event occurring in Philadelphia positive chronic myeloid leukemia. We describe five new cases (two males, three females) where t(3;21) is associated with the progression of the disease. Using FACS analysis, we confirm the myeloid type of the bla...

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Bibliographic Details
Published in:	Leukemia Vol. 3; no. 8; p. 554
Main Authors:	Lafage-Pochitaloff-Huvalé, M, Sainty, D, Adriaanssen, H J, Lopez, M, Maraninchi, D, Simonetti, J, Mannoni, P, Carcassonne, Y, Hagemeijer, A
Format:	Journal Article
Language:	English
Published:	England 01-08-1989
Subjects:	Adult Aged Antigens, Surface - analysis Chromosomes, Human, Pair 21 Chromosomes, Human, Pair 3 Female Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - immunology Male Middle Aged Translocation, Genetic
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Summary:	Translocation t(3;21)(q26;q22) is a rare but nonrandom event occurring in Philadelphia positive chronic myeloid leukemia. We describe five new cases (two males, three females) where t(3;21) is associated with the progression of the disease. Using FACS analysis, we confirm the myeloid type of the blast crisis. High resolution chromosomal analysis allowed us to define more precisely the chromosomal breakpoints to 3q26.2 and 21q22.2, close to the respective localizations of two genes important in cell proliferation and cancer pathogenesis: the transferrin receptor gene and the ets.2 proto-oncogene.
ISSN:	0887-6924