Search Results - "Adragna, C."

K-Cl cotransporters, cell volume homeostasis, and neurological disease by Kahle, Kristopher T, Khanna, Arjun R, Alper, Seth L, Adragna, Norma C, Lauf, Peter K, Sun, Dandan, Delpire, Eric

“…Highlights • KCCs have roles in the nervous system beyond modulating GABAergic signaling. • KCCs regulate nervous system cell volume, and are mutated in…”
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Assessment of Silver-Nanoparticles-Induced Erythrocyte Cytotoxicity through Ion Transport Studies by Adragna, Norma C, Alla, Praveen K, Pavel-Sizmore, Ioana E, Paluri, Arathi S L, Yaklic, Jerome, Lauf, Peter K

“…Silver nanoparticles (AgNPs) are the most frequently used nanomaterials in industrial and biomedical applications. Their functionalization significantly…”
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SERS of Human Red Blood Cells in Non-Resonant Conditions: Benefits, Limitations, and Complementary Tools (CytoViva and GFAAS) by Wells, Kelsey L, Alla, Praveen K, Kaiser, Kyra G, Murgulet, Ioana T, Adragna, Norma C, Pavel, Ioana E

“…Herein, Raman and surface-enhanced Raman spectroscopies (SERS) were successfully employed to establish the chemical interactions of citrate-capped silver…”
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Sea Water Acidification Affects Osmotic Swelling, Regulatory Volume Decrease and Discharge in Nematocytes of the Jellyfish Pelagia noctiluca by Morabito, Rossana, Marino, Angela, Lauf, Peter K., Adragna, Norma C., La Spada, Giuseppa

“…Background: Increased acidification/P CO2 of sea water is a threat to the environment and affects the homeostasis of marine animals. In this study, the effect…”
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K-Cl cotransport: properties and molecular mechanism by Lauf, P K, Adragna, N C

“…K-Cl cotransport (COT), defined first in red blood cells as the Cl-dependent, ouabain-insensitive bidirectional K transport, encoded by at least four KCC…”
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Regulation of K-Cl Cotransport: from Function to Genes by Adragna, N.C, Di Fulvio, M, Lauf, P.K

“…This review intends to summarize the vast literature on K-Cl cotransport (COT) regulation from a functional and genetic viewpoint. Special attention has been…”
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Canonical Bcl-2 Motifs of the Na+/K+ Pump Revealed by the BH3 Mimetic Chelerythrine: Early Signal Transducers of Apoptosis? by Lauf, Peter K., Heiny, Judith, Meller, Jarek, Lepera, Michael A., Koikov, Leonid, Alter, Gerald M., Brown, Thomas L., Adragna, Norma C.

“…Background/Aims: Chelerythrine [CET], a protein kinase C [PKC] inhibitor, is a prop-apoptotic BH3-mimetic binding to BH1-like motifs of Bcl-2 proteins. CET…”
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Erythrocyte Signal Transduction Pathways, their Oxygenation Dependence and Functional Significance by Barvitenko, Nadezhda, Adragna, Norma, Weber, Roy

“…Erythrocytes play a key role in human and vertebrate metabolism. Tissue O 2 supply is regulated by both hemoglobin (Hb)-O 2 affinity and erythrocyte rheology,…”
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Surface-Enhanced Raman Spectroscopy (SERS) Tracking of Chelerythrine, a Na+/K+ Pump Inhibitor, into Cytosol and Plasma Membrane Fractions of Human Lens Epithelial Cell Cultures by Dorney, Kevin M., Sizemore, Ioana E.P., Alqahtani, Tariq, Adragna, Norma C., Lauf, Peter K.

“…Background/Aims: The quaternary benzo-phenanthridine alkaloid (QBA) chelerythrine (CET) is a pro-apoptotic drug and Na + /K + pump (NKP) inhibitor in human…”
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Kinetic studies of K-Cl cotransport in cultured rat vascular smooth muscle cells by Lauf, Peter K, Sharma, Neelima, Adragna, Norma C

“…During aging, and development of atherosclerosis and cardiovascular disease (CVD), aortic vascular smooth muscle cells (VSMCs) transition from healthy…”
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Genetic and biochemical determinants of abnormal monovalent ion transport in primary hypertension by Orlov, S N, Adragna, N C, Adarichev, V A, Hamet, P

“…Data obtained during the last two decades show that spontaneously hypertensive rats, an acceptable experimental model of primary human hypertension, possess…”
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Erythrocyte K-Cl cotransport: properties and regulation by Lauf, P K, Bauer, J, Adragna, N C, Fujise, H, Zade-Oppen, A M, Ryu, K H, Delpire, E

“…Erythrocytes possess a Cl-dependent, Na-independent K transport system cotransporting K and Cl in a 1:1 stoichiometry that is membrane potential independent…”
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Protein Kinase G Regulates Potassium Chloride Cotransporter-3 Expression in Primary Cultures of Rat Vascular Smooth Muscle Cells by Di Fulvio, Mauricio, Lincoln, Thomas M., Lauf, Peter K., Adragna, Norma C.

“…K-Cl cotransport (KCC) is activated by nitric oxide donors and appears to be regulated by the cGMP signaling pathway. Expression of KCC mRNAs (KCC1–KCC4) in…”
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Interaction between Na-K-ATPase and Bcl-2 proteins BclXL and Bak by Lauf, Peter K, Alqahtani, Tariq, Flues, Karin, Meller, Jaroslaw, Adragna, Norma C

“…In silico analysis predicts interaction between Na-K-ATPase (NKA) and Bcl-2 protein canonical BH3- and BH1-like motifs, consistent with NKA inhibition by the…”
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Regulation of potassium transport in human lens epithelial cells by Lauf, Peter K., Warwar, Ronald, Brown, Thomas L., Adragna, Norma C.

“…The major K influx pathways and their response to thiol modification by N-ethylmaleimide (NEM) and protein kinase and phosphatase inhibitors were characterized…”
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Synopsis of the 48th Annual Meeting of the Lake Cumberland Biological Transport Group and the Second Biannual Meeting of the Pendrin Consortium by Dossena, Silvia, Nofziger, Charity, Morabito, Rossana, Adragna, Norma C., Paulmichl, Markus

“…Ion transporters are the molecular basis for ion homeostasis of the cell and the whole organism. The anion exchanger pendrin is only one of a number of…”
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Signal transduction mechanisms of K+-Cl− cotransport regulation and relationship to disease by Adragna, N. C., Ferrell, C. M., Zhang, J., Di Fulvio, M., Temprana, C. F., Sharma, A., Fyffe, R. E. W., Cool, D. R., Lauf, P. K.

“…The K+‐Cl− cotransport (COT) regulatory pathways recently uncovered in our laboratory and their implication in disease state are reviewed. Three mechanisms of…”
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Nitric Oxide Signaling Pathway Regulates Potassium Chloride Cotransporter-1 mRNA Expression in Vascular Smooth Muscle Cells by Di Fulvio, M, Lauf, P K, Adragna, N C

“…Rat vascular smooth muscle cells (VSMCs) express at least two mRNAs for K-Cl cotransporters (KCC): KCC1 and KCC3. cGMP-dependent protein kinase I regulates…”
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K-Cl cotransport in vascular smooth muscle and erythrocytes: possible implication in vasodilation by Adragna, N C, White, R E, Orlov, S N, Lauf, P K

“…K-Cl cotransport, the electroneutral-coupled movement of K and Cl ions, plays an important role in regulatory volume decrease. We recently reported that…”
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Role of protein kinases in regulating sheep erythrocyte K-Cl cotransport by Flatman, P W, Adragna, N C, Lauf, P K

“…K-Cl cotransport in sheep erythrocytes can be activated by treatment either with A-23187 and EDTA to reduce concentration of internal ionized Mg [Mg]i) to…”
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