Search Results - "Adolf, Andrej"
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Release of astroglial vimentin by extracellular vesicles: Modulation of binding and internalization of C3 transferase in astrocytes and neurons
Published in Glia (01-04-2019)“…Clostridium botulinum C3 transferase (C3bot) ADP‐ribosylates rho proteins to change cellular functions in a variety of cell types including astrocytes and…”
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The Higher Sensitivity of GABAergic Compared to Glutamatergic Neurons to Growth-Promoting C3bot Treatment Is Mediated by Vimentin
Published in Frontiers in cellular neuroscience (03-11-2020)“…The current study investigates the neurotrophic effects of Clostridium botulinum C3 transferase (C3bot) on highly purified, glia-free, GABAergic and…”
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The Rho ADP-ribosylating C3 exoenzyme binds cells via an Arg–Gly–Asp motif
Published in The Journal of biological chemistry (27-10-2017)“…The Rho ADP-ribosylating C3 exoenzyme (C3bot) is a bacterial protein toxin devoid of a cell-binding or -translocation domain. Nevertheless, C3 can efficiently…”
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The intermediate filament protein vimentin is essential for axonotrophic effects of Clostridium botulinum C3 exoenzyme
Published in Journal of neurochemistry (01-10-2016)“…The type III intermediate filament protein vimentin was recently identified to mediate binding and uptake of Clostridium botulinum C3 exoenzyme (C3bot) in two…”
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