Search Results - "Adney, Scott K."

Phosphoinositide Control of Membrane Protein Function: A Frontier Led by Studies on Ion Channels by Logothetis, Diomedes E, Petrou, Vasileios I, Zhang, Miao, Mahajan, Rahul, Meng, Xuan-Yu, Adney, Scott K, Cui, Meng, Baki, Lia

“…Anionic phospholipids are critical constituents of the inner leaflet of the plasma membrane, ensuring appropriate membrane topology of transmembrane proteins…”
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Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs by Fribourg, Miguel, Moreno, José L., Holloway, Terrell, Provasi, Davide, Baki, Lia, Mahajan, Rahul, Park, Gyu, Adney, Scott K., Hatcher, Candice, Eltit, José M., Ruta, Jeffrey D., Albizu, Laura, Li, Zheng, Umali, Adrienne, Shim, Jihyun, Fabiato, Alexandre, MacKerell, Alexander D., Brezina, Vladimir, Sealfon, Stuart C., Filizola, Marta, González-Maeso, Javier, Logothetis, Diomedes E.

“…Atypical antipsychotic drugs, such as clozapine and risperidone, have a high affinity for the serotonin 5-HT2A G protein-coupled receptor (GPCR), the 2AR,…”
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PIP2 controls voltage-sensor movement and pore opening of Kv channels through the S4–S5 linker by Rodriguez-Menchaca, Aldo A, Adney, Scott K, Tang, Qiong-Yao, Meng, Xuan-Yu, Rosenhouse-Dantsker, Avia, Cui, Meng, Logothetis, Diomedes E

“…Voltage-gated K + (Kv) channels couple the movement of a voltage sensor to the channel gate(s) via a helical intracellular region, the S4–S5 linker. A number…”
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A Critical Gating Switch at a Modulatory Site in Neuronal Kir3 Channels by Adney, Scott K, Ha, Junghoon, Meng, Xuan-Yu, Kawano, Takeharu, Logothetis, Diomedes E

“…Inwardly rectifying potassium channels enforce tight control of resting membrane potential in excitable cells. The Kir3.2 channel, a member of the Kir3…”
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Functional and pharmacological evaluation of a novel SCN2A variant linked to early‐onset epilepsy by Adney, Scott K., Millichap, John J., DeKeyser, Jean‐Marc, Abramova, Tatiana, Thompson, Christopher H., George, Alfred L.

“…Objective We identified a novel de novo SCN2A variant (M1879T) associated with infantile‐onset epilepsy that responded dramatically to sodium channel blocker…”
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Unifying Mechanism of Controlling Kir3 Channel Activity by G Proteins and Phosphoinositides by Logothetis, Diomedes E, Mahajan, Rahul, Adney, Scott K, Ha, Junghoon, Kawano, Takeharu, Meng, Xuan-Yu, Cui, Meng

“…The question that started with the pioneering work of Otto Loewi in the 1920s, to identify how stimulation of the vagus nerve decreased heart rate, is…”
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Dual Regulation of Voltage-Sensitive Ion Channels by PIP2 by Rodríguez-Menchaca, Aldo A., Adney, Scott K., Zhou, Lei, Logothetis, Diomedes E.

“…Over the past 16 years, there has been an impressive number of ion channels shown to be sensitive to the major phosphoinositide in the plasma membrane,…”
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Channelopathies linked to plasma membrane phosphoinositides by Logothetis, Diomedes E., Petrou, Vasileios I., Adney, Scott K., Mahajan, Rahul

“…The plasma membrane phosphoinositide phosphatidylinositol 4,5-bisphosphate (PIP 2 ) controls the activity of most ion channels tested thus far through direct…”
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Posterior reversible encephalopathy syndrome and takotsubo cardiomyopathy associated with lenvatinib therapy for thyroid cancer: a case report and review by Chae, Young Kwang, Chiec, Lauren, Adney, Scott K, Waitzman, Josh, Costa, Ricardo, Carneiro, Benedito, Matsangou, Maria, Agulnik, Mark, Kopp, Peter, Giles, Frank

“…As immunotherapies including tyrosine kinase inhibitors become more widely used for the treatment of a variety of malignancies, it is important for prescribers…”
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Regulation of Kv2.1 channel inactivation by phosphatidylinositol 4,5-bisphosphate by Delgado-Ramírez, Mayra, De Jesús-Pérez, José J., Aréchiga-Figueroa, Iván A., Arreola, Jorge, Adney, Scott K., Villalba-Galea, Carlos A., Logothetis, Diomedes E., Rodríguez-Menchaca, Aldo A.

“…Phosphatidylinositol 4,5-bisphosphate (PIP 2 ) is a membrane phospholipid that regulates the function of multiple ion channels, including some members of the…”
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Meningeal defects and focal cortical dysplasia: an unrecognized relationship? Illustrative case by Ellis, Erin M., Trybula, S. Joy, Adney, Scott K., Lee, Paula K. J., Bandt, S. Kathleen

“…BACKGROUNDFocal cortical dysplasias (FCDs) are a heterogenous cluster of histopathologic entities classically associated with medically refractory epilepsy…”
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Molecular basis for the modulation of native T-type Ca2+ channels in vivo by Ca2+/calmodulin-dependent protein kinase II by Yao, Junlan, Davies, Lucinda A, Howard, Jason D, Adney, Scott K, Welsby, Philip J, Howell, Nancy, Carey, Robert M, Colbran, Roger J, Barrett, Paula Q

“…Ang II receptor activation increases cytosolic Ca2+ levels to enhance the synthesis and secretion of aldosterone, a recently identified early pathogenic…”
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Unique PIP2 Sensitivity at a Putative PKC Site in GIRK2 (Kir3.2) by Adney, Scott K., Meng, Xuan-Yu, Logothetis, Diomedes E.

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Distant Cytosolic Residues Mediate a Two-way Molecular Switch That Controls the Modulation of Inwardly Rectifying Potassium (Kir) Channels by Cholesterol and Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P2) by Rosenhouse-Dantsker, Avia, Noskov, Sergei, Han, Huazhi, Adney, Scott K., Tang, Qiong-Yao, Rodríguez-Menchaca, Aldo A., Kowalsky, Gregory B., Petrou, Vasileios I., Osborn, Catherine V., Logothetis, Diomedes E., Levitan, Irena

“…Inwardly rectifying potassium (Kir) channels play an important role in setting the resting membrane potential and modulating membrane excitability. An emerging…”
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Dual Regulation of Kv1.2 Activation by PIP2 by Rodriguez-Menchaca, Aldo A., Adney, Scott K., Logothetis, Diomedes E.

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PIP 2 controls voltage-sensor movement and pore opening of Kv channels through the S4–S5 linker by Rodriguez-Menchaca, Aldo A., Adney, Scott K., Tang, Qiong-Yao, Meng, Xuan-Yu, Rosenhouse-Dantsker, Avia, Cui, Meng, Logothetis, Diomedes E.

“…Voltage-gated K + (Kv) channels couple the movement of a voltage sensor to the channel gate(s) via a helical intracellular region, the S4–S5 linker. A number…”
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PIP^sub 2^ controls voltage-sensor movement and pore opening of Kv channels through the S4-S5 linker by Rodriguez-Menchaca, Aldo A, Adney, Scott K, Tang, Qiong-Yao, Meng, Xuan-Yu, Rosenhouse-Dantsker, Avia, Cui, Meng, Logothetis, Diomedes E

“…Voltage-gated K+ (Kv) channels couple the movement of a voltage sensor to the channel gate(s) via a helical intracellular region, the S4-S5 linker. A number of…”
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PIP₂ controls voltage-sensor movement and pore opening of Kv channels through the S4-S5 linker by Rodriguez-Menchaca, Aldo A., Adney, Scott K., Tang, Qiong-Yao, Meng, Xuan-Yu, Rosenhouse-Dantsker, Avia, Cui, Meng, Logothetis, Diomedes E.

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Distant Cytosolic Residues in Kir Channels Control Channel Gating and Modulation by Cholesterol and PI(4,5)P2 by Rosenhouse-Dantsker, Avia, Noskov, Sergei, Han, Huazhi, Adney, Scott K., Tang, Qiong-Yao, Rodríguez-Menchaca, Aldo A., Kowalsky, Gregory B., Petrou, Vasileios I., Osborn, Catherine V., Logothetis, Diomedes E., Levitan, Irena

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Regulation Of The Slo2.2 Channel By Na+ Ions And Phosphatidylinositol 4,5 Bisphosphate by Zhang, Zhe, Rosenhouse-Dantsker, Avia, Adney, Scott K., Logothetis, Diomedes E.

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