Search Results - "Adler, Victor"

Role of redox potential and reactive oxygen species in stress signaling: Stress signaling by ADLER, V, ZHIMIN YIN, TEW, K. D, RONAI, Z

“…Stress-activated signaling cascades are affected by altered redox potential. Key contributors to altered redox potential are reactive oxygen species (ROS)…”
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MEKK1/JNK Signaling Stabilizes and Activates p53 by Fuchs, Serge Y., Adler, Victor, Pincus, Matthew R., Ze'ev Ronai

“…Activation of the tumor suppressor p53 by stress and damage stimuli often correlates with induction of stress kinases, Jun-NH2kinase (JNK). As JNK association…”
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Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes by Sarafraz-Yazdi, Ehsan, Bowne, Wilbur B, Adler, Victor, Sookraj, Kelley A, Wu, Vernon, Shteyler, Vadim, Patel, Hunaiz, Oxbury, William, Brandt-Rauf, Paul, Zenilman, Michael E, Michl, Josef, Pincus, Matthew R

“…The anticancer peptide PNC-27, which contains an HDM-2-binding domain corresponding to residues 12-26 of p53 and a transmembrane-penetrating domain, has been…”
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JNK targets p53 ubiquitination and degradation in nonstressed cells by Fuchs, S Y, Adler, V, Buschmann, T, Yin, Z, Wu, X, Jones, S N, Ronai, Z

“…In this study we elucidated the role of nonactive JNK in regulating p53 stability. The amount of p53-JNK complex was inversely correlated with p53 level. A…”
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Anti-cancer peptides from ras-p21 and p53 proteins by Pincus, Matthew R, Fenelus, Maly, Sarafraz-Yazdi, Ehsan, Adler, Victor, Bowne, Wilbur, Michl, Josef

“…We have employed computer-based molecular modeling approaches to design peptides from the ras-p21 and p53 proteins that either induce tumor cell reversion to…”
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UV Irradiation and Heat Shock Mediate JNK Activation via Alternate Pathways (∗) by Adler, Victor, Schaffer, Andràs, Kim, Jeanette, Dolan, Lisa, Ronai, Ze'ev

“…To elucidate cellular pathways involved in Jun-NH2-terminal kinase (JNK) activation by different forms of stress, we have compared the effects of UV…”
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c-Jun NH2-terminal Kinases Target the Ubiquitination of Their Associated Transcription Factors by Fuchs, Serge Y., Xie, Bin, Adler, Victor, Fried, Victor A., Davis, Roger J., Ronai, Ze'ev

“…Regulatory proteins are often ubiquitinated, depending on their phosphorylation status as well as on their association with ancillary proteins that serve as…”
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p53-Derived peptide targets a novel death pathway inducing selective necrosis in cancer cells by Sookraj, Kelley A., MD, Adler, Victor, MD, PhD, Yazdi, Ehsan, MS, Zenilman, Michael E., MD, FACS, Michl, Josef, MD, Pincus, Matthew R., MD, PhD, Bowne, Wilbur B., MD

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Stabilization and Activation of p53 are Regulated Independently by Different Phosphorylation Events by Chernov, Mikhail V., Ramana, Chilakamarti V., Adler, Victor V., Stark, George R.

“…Treatment of mouse or human cells with the protein kinase C (PKC) inhibitors H7 or bisindolylmaleimide I induced an increase in the lifetime of p53, leading to…”
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Novel p53-derived peptide induces necrosis by membrane-pore formation in pancreatic cancer cells by Sookraj, Kelley A., MD, Adler, Victor, MD, PhD, Yazdi, Ehsan S., MS, Zenilman, Michael E., MD, FACS, Michl, Josef, MD, Pincus, Matthew R., MD, PhD, Bowne, Wilbur B., MD

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Conformation-Dependent Phosphorylation of p53 by Adler, Victor, Pincus, Matthew R., Minamoto, Toshinari, Fuchs, Serge Y., Bluth, Mark J., Brand-Rauf, Paul W., Friedman, Fred K., Robinson, Richard C., Chen, James M., Wang, Xin Wei, Harris, Curtis C., Ze'ev Ronai

“…Phosphorylation of the p53 tumor suppressor protein is known to modulate its functions. Using bacterially produced glutathione S-transferase (GST)-p53 fusion…”
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Contribution of phosphatidylinositol 3-kinase to radiation resistance in human melanoma cells by Krasilnikov, Mikhail, Adler, Victor, Fuchs, Serge Y., Dong, Zheng, Haimovitz-Friedman, Adriana, Herlyn, Meenhard, Ronai, Ze'ev

“…The activity of phosphatidylinositol 3‐kinase (PI3K), a key component of multiple signal transduction pathways, was investigated in early‐ and late‐stage…”
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Small, Highly Structured RNAs Participate in the Conversion of Human Recombinant PrPSen to PrPRes in Vitro by Adler, Victor, Zeiler, Brian, Kryukov, Valentin, Kascsak, Richard, Rubenstein, Richard, Grossman, Abraham

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Anti-Cancer Peptide PNC-27 Kills Cancer Cells by Unique Interactions with Plasma Membrane-Bound hdm-2 and with Mitochondrial Membranes Causing Mitochondrial Disruption by Krzesaj, Patryk, Adler, Victor, Feinman, Richard D, Miller, Anna, Silberstein, Miriam, Yazdi, Ehsan, Pincus, Matthew R

“…We have previously shown that the anti-cancer peptide PNC-27 kills cancer cells by co-localizing with membrane-expressed HDM-2, resulting in transmembrane pore…”
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Abstract LB218: Advanced ex vivo platform for drug response analysis: Evaluating the potent effects of NMC-521 mAb on mouse-and patient-derived organotypic tumor spheroids by Aref, Amir, Martin, Alyssa, Aboulkheyr Es, Hamidreza, Krzesaj, Patryk, Adler, Victor, Khardenavis, Kirti, Sarafraz-Yazdi, Ehsan, Perricone, Michael A.

“…Abstract In response to the high failure rate of new drugs in clinical trials, we have developed an innovative organotypic tumor spheroids platform, designed…”
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The writer's ethics and the commitment of children's literature to the formation of critical readers--the work of Georgina Martins /A etica na escrita e o empenho da literatura infantojuvenil na formacao de leitores criticos--a obra de Georgina Martins by Pereira, Victor Hugo Adler

“…The work analyzes the directions taken by literature that presents children with social problems and conflicts and pressing human issues. With the aim of…”
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Regulation of JNK signaling by GSTp by Adler, Victor, Yin, Zhimin, Fuchs, Serge Y., Benezra, Miriam, Rosario, Lilliam, Tew, Kenneth D., Pincus, Matthew R., Sardana, Mohinder, Henderson, Colin J., Wolf, C.Roland, Davis, Roger J., Ronai, Ze'ev

“…Studies of low basal Jun N‐terminal kinase (JNK) activity in non‐stressed cells led us to identify a JNK inhibitor that was purified and identified as…”
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Torto Arado, de Itamar Vieira Junior by Pereira, Victor Hugo Adler

“…Resenha…”
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Small, highly structured RNAs participate in the conversion of human recombinant PrP(Sen) to PrP(Res) in vitro by Adler, Victor, Zeiler, Brian, Kryukov, Valentin, Kascsak, Richard, Rubenstein, Richard, Grossman, Abraham

“…We have identified a small, highly structured (shs)RNA that binds human recombinant prion protein (hrPrP) with high affinity and specificity under…”
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The anti-cancer peptide, PNC-27, induces tumor cell lysis as the intact peptide by Sookraj, Kelley A., Bowne, Wilbur B., Adler, Victor, Sarafraz-Yazdi, Ehsan, Michl, Josef, Pincus, Matthew R.

“…Purpose PNC-27, a peptide that contains an HDM-2-binding domain from p53 attached to a membrane-penetrating peptide on its carboxyl terminal end, is cytotoxic…”
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