Search Results - "Adler, Scott H."

Sodium Zirconium Cyclosilicate among Individuals with Hyperkalemia: A 12-Month Phase 3 Study by Spinowitz, Bruce S, Fishbane, Steven, Pergola, Pablo E, Roger, Simon D, Lerma, Edgar V, Butler, Javed, von Haehling, Stephan, Adler, Scott H, Zhao, June, Singh, Bhupinder, Lavin, Philip T, McCullough, Peter A, Kosiborod, Mikhail, Packham, David K

“…Oral sodium zirconium cyclosilicate (formerly ZS-9) binds and removes potassium the gastrointestinal tract. Sodium zirconium cyclosilicate-associated…”
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Anti-interleukin-6 antibody clazakizumab in late antibody-mediated kidney transplant rejection: effect on cytochrome P450 drug metabolism by Mühlbacher, Jakob, Schörgenhofer, Christian, Doberer, Konstantin, Dürr, Michael, Budde, Klemens, Eskandary, Farsad, Mayer, Katharina A, Schranz, Sabine, Ely, Sarah, Reiter, Birgit, Chong, Edward, Adler, Scott H, Jilma, Bernd, Böhmig, Georg A

“…Targeting interleukin-6 (IL-6) is a promising strategy to counteract antibody-mediated rejection (ABMR). In inflammatory states, IL-6 antagonism was shown to…”
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Notch and the Immune System by Maillard, Ivan, Adler, Scott H., Pear, Warren S.

“…Notch proteins are used repeatedly to direct developmental cell fate decisions in multiple organs. During hematopoiesis and immune development, Notch is…”
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Notch Signaling Augments T Cell Responsiveness by Enhancing CD25 Expression by Adler, Scott H, Chiffoleau, Elise, Xu, Lanwei, Dalton, Nicole M, Burg, Jennifer M, Wells, Andrew D, Wolfe, Michael S, Turka, Laurence A, Pear, Warren S

“…Notch receptors signal through a highly conserved pathway to influence cell fate decisions. Notch1 is required for T lineage commitment; however, a role for…”
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Characterization of renal biomarkers for use in clinical trials: biomarker evaluation in healthy volunteers by Brott, David A, Adler, Scott H, Arani, Ramin, Lovick, Susan C, Pinches, Mark, Furlong, Stephen T

“…Several preclinical urinary biomarkers have been qualified and accepted by the health authorities (US Food and Drug Administration, European Medicines Agency,…”
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Characterization of renal biomarkers for use in clinical trials: effect of preanalytical processing and qualification using samples from subjects with diabetes by Brott, David A, Furlong, Stephen T, Adler, Scott H, Hainer, James W, Arani, Ramin B, Pinches, Mark, Rossing, Peter, Chaturvedi, Nish

“…Identifying the potential for drug-induced kidney injury is essential for the successful research and development of new drugs. Newer and more sensitive…”
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Bcl-XL Expression in Stem Cells Facilitates Engraftment and Reduces the Need for Host Conditioning During Bone Marrow Transplantation by Mata, Marielena, Chiffoleau, Elise, Adler, Scott H, Gray, Tynua, Hancock, Wayne, Turka, Laurence A

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An open-label, pilot study evaluating the safety and efficacy of converting from calcineurin inhibitors to sirolimus in established renal allograft recipients with moderate renal insufficiency by Ram Peddi, V, Jensik, Stephen, Pescovitz, Mark, Pirsch, John, Adler, Scott H, Richard Thistlethwaite, J, Vincenti, Flavio, Cohen, David J

“…:  This pilot study was designed to evaluate the safety and efficacy of converting from a calcineurin inhibitor (CI) to a sirolimus (SRL)‐based regimen in…”
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Bcl‐XL Expression in Stem Cells Facilitates Engraftment and Reduces the Need for Host Conditioning During Bone Marrow Transplantation by Mata, Marielena, Chiffoleau, Elise, Adler, Scott H., Gray, Tynua, Hancock, Wayne, Turka, Laurence A.

“…The prolonged survival of donor hematopoietic stem cells is crucial to the success of bone marrow transplantation. The anti‐apoptotic gene Bcl‐xL has been…”
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Encaleret Normalized Mineral Homeostasis in Autosomal Dominant Hypocalcemia Type 1 (ADH1) in a Phase 2 Study: FR-OR08 by Roszko, Kelly, Gafni, Rachel, Hartley, Iris R., Nemeth, Edward F., Pozo, Karen A., Lombardi, Ed, Roberts, Mary S., Adler, Scott H., Collins, Michael

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Stemming the tide of rejection by Adler, Scott H, Bensinger, Steven J, Turka, Laurence A

“…Transplant recipients require chronic administration of drugs that suppress their immune system to prevent rejection of foreign tissues. The finding in rats…”
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OR23-03 Sustained Normalization Of Mineral Homeostasis In Autosomal Dominant Hypocalcemia Type 1: Results From A Phase 2 Study Over 18 Months Of Encaleret (CLTX-305) Treatment (NCT04581629) by Ilana Gafni, Rachel, Ruth Hartley, Iris, Lauter Roszko, Kelly, Nemeth, Edward F, Pozo, Karen A, Mathew, Arun, Scott Roberts, Mary, Adler, Scott H, Collins, Michael T

“…Disclosure: R.I. Gafni: Advisory Board Member; Self; Ascendis Pharma, Hypoparathyroidism Association. Grant Recipient; Self; Calcilytix Therapeutics. I.R…”
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Immunotherapy as a means to induce transplantation tolerance by Adler, Scott H, Turka, Laurence A

“…There have been several recent advances in the use of immunotherapy to induce transplantation tolerance. These include newer and safer protocols to create…”
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Nuclear factor-κB binding to the HIV-1 LTR in kidney: Implications for HIV-associated nephropathy by Bruggeman, Leslie A., Adler, Scott H., Klotman, Paul E.

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Negative ion chemical ionization mass spectrometry of deoxynivalenol (DON): application to identification of DON in grains and snack foods after quantitation/isolation by thin-layer chromatography by Brumley, William C, Trucksess, Mary W, Adler, Scott H, Cohen, Clara K, White, Kevin D, Sphon, James A

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Nuclear factor- B binding to the HIV-1 LTR in kidney: Implications for HIV-associated nephropathy by Bruggeman, Leslie A, Adler, Scott H, Klotman, Paul E

“…We have recently shown that renal epithelium is infected by HIV-1 and supports HIV-1 transcription in seropositive patients with renal disease. To investigate…”
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Progressive Glomerulosclerosis and Enhanced Renal Accumulation of Basement Membrane Components in Mice Transgenic for Human Immunodeficiency Virus Type 1 Genes by Kopp, Jeffrey B., Klotman, Mary E., Adler, Scott H., Bruggeman, Leslie A., Dickie, Peter, Marinos, Nancy J., Eckhaus, Michael, Bryant, Joseph L., Notkins, Abner L., Klotman, Paul E.

“…Patients infected with human immunodeficiency virus type 1 (HIV-1) develop a renal syndrome characterized by proteinuria, renal failure, and focal segmental…”
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Nuclear factor-kB binding to the HIV-1 LTR in kidney : Implications for HIV-associated nephropathy by BRUGGEMAN, Leslie A, ADLER, Scott H, KLOTMAN, Paul E

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Nuclear factor-κB binding to the HIV-1 LTR in kidney: Implications for HIV-associated nephropathy by Bruggeman, Leslie A., Adler, Scott H., Klotman, Paul E.

“…Nuclear factor-κB binding to the HIV-1 LTR in kidney: Implications for HIV-associated nephropathy. We have recently shown that renal epithelium is infected by…”
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Laminin in neuronal development by Kleinman, H K, Sephel, G C, Tashiro, K, Weeks, B S, Burrous, B A, Adler, S H, Yamada, Y, Martin, G R

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