Search Results - "Adler, Marc J."

Opportunities and Challenges for the Development of MRCK Kinases Inhibitors as Potential Cancer Chemotherapeutics by Ruscetta, Vanessa M, Seaton, Taj J, Shakeel, Aleen, Vasconcelos, Stanley N S, Viirre, Russell D, Adler, Marc J, Olson, Michael F

“…Cytoskeleton organization and dynamics are rapidly regulated by post-translational modifications of key target proteins. Acting downstream of the Cdc42 GTPase,…”
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Direct Alkylative Amination Using 1‐Allylsilatrane by Raveenthrarajan, David, Satkunarajah, Thershan, Kostiuk, Brooklyn A., Adler, Marc J.

“…Homoallylic amines prepared via addition of allylsilanes often require preformed imine substrates, metal catalysts, fluoride activators, or use of protected…”
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Chiral Brønsted Acid-Catalyzed Metal-Free Asymmetric Direct Reductive Amination Using 1‑Hydrosilatrane by Skrypai, Vladislav, Varjosaari, Sami E, Azam, Fawwaz, Gilbert, Thomas M, Adler, Marc J

“…The asymmetric direct reductive amination of prochiral ketones with aryl amines using 1-hydrosilatrane with a chiral Brønsted acid catalyst is reported. This…”
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Computational Study of Ways by Which exo-Silatranes Might Be Prepared by Hoeksema, Carolynn, Adler, Marc J, Gilbert, Thomas M

“…exo-Silatranes involve cage structures where the nitrogen lone pair points away from the cage rather than into it. This distinguishes them from the…”
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Silatrane as a Practical and Selective Reagent for the Reduction of Aryl Aldehydes to Benzylic Alcohols by Skrypai, Vladislav, Hurley, Joseph J. M., Adler, Marc J.

“…Hydrosilanes are cheap, readily available substrates, yet they do not see as extensive use for simple carbonyl reductions as borohydrides. Hydrosilane reducing…”
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Simple Metal‐Free Direct Reductive Amination Using Hydrosilatrane to Form Secondary and Tertiary Amines by Varjosaari, Sami E., Skrypai, Vladislav, Suating, Paolo, Hurley, Joseph J. M., Lio, Ashley M. De, Gilbert, Thomas M., Adler, Marc J.

“…This work describes the use of cheap, safe, and easy‐to‐handle hydrosilatrane as the reductant in direct reductive amination reactions. This efficient method…”
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Control of Porphyrin Planarity and Aggregation by Covalent Capping: Bissilyloxy Porphyrin Silanes by Hussein, Burhan A, Shakeel, Zainab, Turley, Andrew T, Bismillah, Aisha N, Wolfstadt, Kody M, Pia, Julia E, Pilkington, Melanie, McGonigal, Paul R, Adler, Marc J

“…Porphyrins are cornerstone functional materials that are useful in a wide variety of settings, ranging from molecular electronics to biology and medicine…”
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1‐Hydrosilatrane: A Locomotive for Efficient Ketone Reductions by Varjosaari, Sami E., Skrypai, Vladislav, Suating, Paolo, Hurley, Joseph J. M., Gilbert, Thomas M., Adler, Marc J.

“…An efficient method for the reduction of ketones with 1‐hydrosilatrane is described. In the presence of a Lewis base activator, the resulting secondary…”
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Oligophenylenaminones as Scaffolds for α-Helix Mimicry by Adler, Marc J, Hamilton, Andrew D

“…The design and synthesis of small molecule α-helix mimetics has been a productive field over the past decade. These compounds have performed well in a variety…”
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Extended Aromatic and Heteroaromatic Ring Systems in the Chalcone–Flavanone Molecular Switch Scaffold by Muller, Brian M, Litberg, Theodore J, Yocum, Reid A, Pniewski, Chanté A, Adler, Marc J

“…Previous work on the o-hydroxychalcone/flavanone molecular switching scaffold showed that simple substitutions alter the pH range in which rapid…”
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Front Cover: 1‐Hydrosilatrane: A Locomotive for Efficient Ketone Reductions (Eur. J. Org. Chem. 2/2017) by Varjosaari, Sami E., Skrypai, Vladislav, Suating, Paolo, Hurley, Joseph J. M., Gilbert, Thomas M., Adler, Marc J.

“…The cover picture shows artist Jesse Mai's imagination of the reduction of ketones to alcohols by 1‐hydrosilatrane. The accompanying work describes this mild…”
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Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions by Adler, Marc J, Jamieson, Andrew G, Hamilton, Andrew D

“…Small molecules which can mimic the key structural facets of protein secondary structure, in particular the α-helix, β-strand, and β-sheet, have been shown to…”
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Enaminone-Based Mimics of Extended and Hydrophilic α-Helices by Adler, Marc J., Scott, Richard T. W., Hamilton, Andrew D.

“…Synthetic molecules capable of the mimicry of α‐helices that are elongated and/or contain hydrophilic side chains have been largely elusive. However, the…”
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Stereoelectronics of silyloxybenzoic acids by Varjosaari, Sami E., Hess, Jeremy P., Suating, Paolo, Price, John M., Gilbert, Thomas M., Adler, Marc J.

“…[Display omitted] Synthetic organic chemists generally think of silyl ethers as easier-to-cleave alkyl ethers, frequently neglecting to consider both the…”
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Altered Binding of a Multimeric Protein by Changing the Self-Assembling Properties of its Substrate by Rosenzweig, Brooke A, Ross, Nathan T, Adler, Marc J, Hamilton, Andrew D

“…Artificially controlled cell recognition has potentially far-reaching applications in both the understanding and altering of biological function. The event of…”
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One-Pot Reductive Acetylation of Aldehydes using 1-Hydrosilatrane in Acetic Acid by James, Reuben, Herlugson, Sharon, Varjosaari, Sami, Skrypai, Vladislav, Shakeel, Zainab, Gilbert, Thomas, Adler, Marc

“…A one-pot, direct reductive acetylation of aldehydes was achieved under mild conditions using 1-hydrosilatrane as a safe and easily accessible catalyst…”
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Metal-free selective reduction of acid chlorides to aldehydes using 1-hydrosilatrane by Azam, Fawwaz, Raveenthrarajan, David, Adler, Marc J.

“…•metal-free•commercially available silane reagent•straightforward reaction setup and workup•no over-reduction observed This work uses 1-hydrosilatrane – an…”
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Forensics as a Gateway: Promoting Undergraduate Interest in Science, and Graduate Student Professional Development through a First-Year Seminar Course by Charkoudian, Louise K, Heymann, Jared J, Adler, Marc J, Haas, Kathryn L, Mies, Kassy A, Bonk, James F

“…A group of five graduate students and a faculty mentor used the cultural popularity of forensics to develop a first-year undergraduate seminar. This course…”
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Porphyrin silanes by Pia, Julia E., Hussein, Burhan A., Skrypai, Vladislav, Sarycheva, Olga, Adler, Marc J.

“…•Porphyrin silanes have been known since 1967.•Not nearly as well explored as many other metalloporphyrins.•Their covalent axial ligands serve as a handle to…”
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Computational investigation of the effect of alkoxy carbon substitution on the mechanism of carbonyl group reduction by 1-hydridosilatranes by Pixler, Alexander S., DeLio, Ashley M., Varjosaari, Sami E., Skrypai, Vladislav, Adler, Marc J., Gilbert, Thomas M.

“…•Computational studies of reduction of acetone by 1-hydridosilatranes show sizably exergonic formation of dialkoxides, in agreement with experiment.•Reductions…”
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