Search Results - "Adler, Julia M"

Development of safe and highly protective live-attenuated SARS-CoV-2 vaccine candidates by genome recoding by Trimpert, Jakob, Dietert, Kristina, Firsching, Theresa C., Ebert, Nadine, Thi Nhu Thao, Tran, Vladimirova, Daria, Kaufer, Susanne, Labroussaa, Fabien, Abdelgawad, Azza, Conradie, Andelé, Höfler, Thomas, Adler, Julia M., Bertzbach, Luca D., Jores, Joerg, Gruber, Achim D., Thiel, Volker, Osterrieder, Nikolaus, Kunec, Dusan

“…Safe and effective vaccines are urgently needed to stop the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We construct a…”
Get full text

An intranasal live-attenuated SARS-CoV-2 vaccine limits virus transmission by Adler, Julia M., Martin Vidal, Ricardo, Langner, Christine, Vladimirova, Daria, Abdelgawad, Azza, Kunecova, Daniela, Lin, Xiaoyuan, Nouailles, Geraldine, Voss, Anne, Kunder, Sandra, Gruber, Achim D., Wu, Haibo, Osterrieder, Nikolaus, Kunec, Dusan, Trimpert, Jakob

“…The development of effective SARS-CoV-2 vaccines has been essential to control COVID-19, but significant challenges remain. One problem is intramuscular…”
Get full text

Inhibition of SARS-CoV-2 Replication by a Small Interfering RNA Targeting the Leader Sequence by Tolksdorf, Beatrice, Nie, Chuanxiong, Niemeyer, Daniela, Röhrs, Viola, Berg, Johanna, Lauster, Daniel, Adler, Julia M., Haag, Rainer, Trimpert, Jakob, Kaufer, Benedikt, Drosten, Christian, Kurreck, Jens

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected almost 200 million people worldwide and led to approximately 4 million deaths as of…”
Get full text

The FDA-Approved Drug Cobicistat Synergizes with Remdesivir To Inhibit SARS-CoV-2 Replication In Vitro and Decreases Viral Titers and Disease Progression in Syrian Hamsters by Shytaj, Iart Luca, Fares, Mohamed, Gallucci, Lara, Lucic, Bojana, Tolba, Mahmoud M, Zimmermann, Liv, Adler, Julia M, Xing, Na, Bushe, Judith, Gruber, Achim D, Ambiel, Ina, Taha Ayoub, Ahmed, Cortese, Mirko, Neufeldt, Christopher J, Stolp, Bettina, Sobhy, Mohamed Hossam, Fathy, Moustafa, Zhao, Min, Laketa, Vibor, Diaz, Ricardo Sobhie, Sutton, Richard E, Chlanda, Petr, Boulant, Steeve, Bartenschlager, Ralf, Stanifer, Megan L, Fackler, Oliver T, Trimpert, Jakob, Savarino, Andrea, Lusic, Marina

“…Combinations of direct-acting antivirals are needed to minimize drug resistance mutations and stably suppress replication of RNA viruses. Currently, there are…”
Get full text

Single-cell-resolved interspecies comparison shows a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19 by Peidli, Stefan, Nouailles, Geraldine, Wyler, Emanuel, Adler, Julia M., Kunder, Sandra, Voß, Anne, Kazmierski, Julia, Pott, Fabian, Pennitz, Peter, Postmus, Dylan, Teixeira Alves, Luiz Gustavo, Goffinet, Christine, Gruber, Achim D., Blüthgen, Nils, Witzenrath, Martin, Trimpert, Jakob, Landthaler, Markus, Praktiknjo, Samantha D.

“…A key issue for research on COVID-19 pathogenesis is the lack of biopsies from patients and of samples at the onset of infection. To overcome these hurdles,…”
Get full text

In vitro and in vivo effects of Pelargonium sidoides DC. root extract EPs ® 7630 and selected constituents against SARS-CoV-2 B.1, Delta AY.4/AY.117 and Omicron BA.2 by Emanuel, Jackson, Papies, Jan, Galander, Celine, Adler, Julia M, Heinemann, Nicolas, Eschke, Kathrin, Merz, Sophie, Pischon, Hannah, Rose, Ruben, Krumbholz, Andi, Kulić, Žarko, Lehner, Martin D, Trimpert, Jakob, Müller, Marcel A

“…The occurrence of immune-evasive SARS-CoV-2 strains emphasizes the importance to search for broad-acting antiviral compounds. Our previous study showed that…”
Get full text

Improving the Antigenicity of SARS-CoV-2 Vaccine Genes by Merging Mutations from Different Variants of Concern by Herwig, Susanne, Adler, Julia M, Vladimirova, Daria, Trimpert, Jakob, Sehouli, Jalid, Cichon, Günter

“…During the COVID-19 pandemic, the early emergence of viral variants repeatedly undermined the effects of vaccination. Our aim here is to explore strategies for…”
Get full text

Early protective effect of a ("pan") coronavirus vaccine (PanCoVac) in Roborovski dwarf hamsters after single-low dose intranasal administration by Abdelaziz, Mohammed O, Raftery, Martin J, Weihs, Julian, Bielawski, Olivia, Edel, Richard, Köppke, Julia, Vladimirova, Daria, Adler, Julia M, Firsching, Theresa, Voß, Anne, Gruber, Achim D, Hummel, Luca V, Fernandez Munoz, Ivan, Müller-Marquardt, Francesca, Willimsky, Gerald, Elleboudy, Nooran S, Trimpert, Jakob, Schönrich, Günther

“…The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted the danger posed by…”
Get full text

Deciphering the Role of Humoral and Cellular Immune Responses in Different COVID-19 Vaccines-A Comparison of Vaccine Candidate Genes in Roborovski Dwarf Hamsters by Trimpert, Jakob, Herwig, Susanne, Stein, Julia, Vladimirova, Daria, Adler, Julia M, Abdelgawad, Azza, Firsching, Theresa C, Thoma, Tizia, Sehouli, Jalid, Osterrieder, Klaus, Gruber, Achim D, Sawitzki, Birgit, Sander, Leif Erik, Cichon, Günter

“…With the exception of inactivated vaccines, all SARS-CoV-2 vaccines currently used for clinical application focus on the spike envelope glycoprotein as a…”
Get full text

Preclinical safety and efficacy of a therapeutic antibody that targets SARS-CoV-2 at the sotrovimab face but is escaped by Omicron by Kreye, Jakob, Reincke, S. Momsen, Edelburg, Stefan, Jeworowski, Lara M., Kornau, Hans-Christian, Trimpert, Jakob, Hombach, Peter, Halbe, Sophia, Nölle, Volker, Meyer, Martin, Kattenbach, Stefanie, Sánchez-Sendin, Elisa, Schmidt, Marie L., Schwarz, Tatjana, Rose, Ruben, Krumbholz, Andi, Merz, Sophie, Adler, Julia M., Eschke, Kathrin, Abdelgawad, Azza, Schmitz, Dietmar, Sander, Leif E., Janssen, Uwe, Corman, Victor M., Prüss, Harald

“…The recurrent emerging of novel viral variants of concern (VOCs) with evasion of preexisting antibody immunity upholds severe acute respiratory syndrome…”
Get full text

Virus-induced senescence is a driver and therapeutic target in COVID-19 by Lee, Soyoung, Yu, Yong, Trimpert, Jakob, Benthani, Fahad, Mairhofer, Mario, Richter-Pechanska, Paulina, Wyler, Emanuel, Belenki, Dimitri, Kaltenbrunner, Sabine, Pammer, Maria, Kausche, Lea, Firsching, Theresa C., Dietert, Kristina, Schotsaert, Michael, Martínez-Romero, Carles, Singh, Gagandeep, Kunz, Séverine, Niemeyer, Daniela, Ghanem, Riad, Salzer, Helmut J. F., Paar, Christian, Mülleder, Michael, Uccellini, Melissa, Michaelis, Edward G., Khan, Amjad, Lau, Andrea, Schönlein, Martin, Habringer, Anna, Tomasits, Josef, Adler, Julia M., Kimeswenger, Susanne, Gruber, Achim D., Hoetzenecker, Wolfram, Steinkellner, Herta, Purfürst, Bettina, Motz, Reinhard, Di Pierro, Francesco, Lamprecht, Bernd, Osterrieder, Nikolaus, Landthaler, Markus, Drosten, Christian, García-Sastre, Adolfo, Langer, Rupert, Ralser, Markus, Eils, Roland, Reimann, Maurice, Fan, Dorothy N. Y., Schmitt, Clemens A.

“…Derailed cytokine and immune cell networks account for the organ damage and the clinical severity of COVID-19 (refs. 1 – 4 ). Here we show that SARS-CoV-2,…”
Get full text

A non-transmissible live attenuated SARS-CoV-2 vaccine by Adler, Julia M., Martin Vidal, Ricardo, Voß, Anne, Kunder, Sandra, Nascimento, Mariana, Abdelgawad, Azza, Langner, Christine, Vladimirova, Daria, Osterrieder, Nikolaus, Gruber, Achim D., Kunec, Dusan, Trimpert, Jakob

“…Live attenuated vaccines (LAVs) administered via the mucosal route may offer better control of the COVID-19 pandemic than non-replicating vaccines injected…”
Get full text

Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics by Wyler, Emanuel, Adler, Julia M., Eschke, Kathrin, Teixeira Alves, G., Peidli, Stefan, Pott, Fabian, Kazmierski, Julia, Michalick, Laura, Kershaw, Olivia, Bushe, Judith, Andreotti, Sandro, Pennitz, Peter, Abdelgawad, Azza, Postmus, Dylan, Goffinet, Christine, Kreye, Jakob, Reincke, S Momsen, Prüss, Harald, Blüthgen, Nils, Gruber, Achim D., Kuebler, Wolfgang M., Witzenrath, Martin, Landthaler, Markus, Nouailles, Geraldine, Trimpert, Jakob

“…For coronavirus disease 2019 (COVID-19), effective and well-understood treatment options are still scarce. Since vaccine efficacy is challenged by novel…”
Get full text

Functionalized Fullerene for Inhibition of SARS‐CoV‐2 Variants by Page, Taylor M., Nie, Chuanxiong, Neander, Lenard, Povolotsky, Tatyana L., Sahoo, Anil Kumar, Nickl, Philip, Adler, Julia M., Bawadkji, Obida, Radnik, Jörg, Achazi, Katharina, Ludwig, Kai, Lauster, Daniel, Netz, Roland R., Trimpert, Jakob, Kaufer, Benedikt, Haag, Rainer, Donskyi, Ievgen S.

“…As virus outbreaks continue to pose a challenge, a nonspecific viral inhibitor can provide significant benefits, especially against respiratory viruses…”
Get full text

Mucus‐Inspired Self‐Healing Hydrogels: A Protective Barrier for Cells against Viral Infection by Bej, Raju, Stevens, Corey Alfred, Nie, Chuanxiong, Ludwig, Kai, Degen, George D., Kerkhoff, Yannic, Pigaleva, Marina, Adler, Julia M., Bustos, Nicole A., Page, Taylor M., Trimpert, Jakob, Block, Stephan, Kaufer, Benedikt B., Ribbeck, Katharina, Haag, Rainer

“…Mucus is a dynamic biological hydrogel, composed primarily of the glycoprotein mucin, exhibits unique biophysical properties and forms a barrier protecting…”
Get full text

Mucin‐Inspired Single‐Chain Polymer (MIP) Fibers as Potent SARS‐CoV‐2 Inhibitors by Bej, Raju, Nie, Chuanxiong, Ludwig, Kai, Ahmadi, Vahid, Trimpert, Jakob, Adler, Julia M., Povolotsky, Tatyana L., Achazi, Katharina, Kagelmacher, Marten, Vidal, Ricardo Martin, Dernedde, Jens, Kaufer, Benedikt B., Haag, Rainer

“…Mucins are the key component of the defensive mucus barrier. They are extended fibers of very high molecular weight with diverse biological functions depending…”
Get full text

Antigenic cartography using variant-specific hamster sera reveals substantial antigenic variation among Omicron subvariants by Mühlemann, Barbara, Trimpert, Jakob, Walper, Felix, Schmidt, Marie L, Jansen, Jenny, Schroeder, Simon, Jeworowski, Lara M, Beheim-Schwarzbach, Jörn, Bleicker, Tobias, Niemeyer, Daniela, Richter, Anja, Adler, Julia M, Vidal, Ricardo Martin, Langner, Christine, Vladimirova, Daria, Wilks, Samuel H, Smith, Derek J, Voß, Mathias, Paltzow, Lea, Martínez Christophersen, Christina, Rose, Ruben, Krumbholz, Andi, Jones, Terry C, Corman, Victor M, Drosten, Christian

“…Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) has developed substantial antigenic variability. As the majority of the population now has…”
Get full text

Live attenuated virus vaccine protects against SARS-CoV-2 variants of concern B.1.1.7 (Alpha) and B.1.351 (Beta) by Trimpert, Jakob, Adler, Julia M, Eschke, Kathrin, Abdelgawad, Azza, Firsching, Theresa C, Ebert, Nadine, Thao, Tran Thi Nhu, Gruber, Achim D, Thiel, Volker, Osterrieder, Nikolaus, Kunec, Dusan

“…Vaccines are instrumental and indispensable in the fight against the COVID-19 pandemic. Several recent SARS-CoV-2 variants are more transmissible and evade…”
Get full text

Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters by Nouailles, Geraldine, Adler, Julia M., Pennitz, Peter, Peidli, Stefan, Teixeira Alves, Luiz Gustavo, Baumgardt, Morris, Bushe, Judith, Voss, Anne, Langenhagen, Alina, Langner, Christine, Martin Vidal, Ricardo, Pott, Fabian, Kazmierski, Julia, Ebenig, Aileen, Lange, Mona V., Mühlebach, Michael D., Goekeri, Cengiz, Simmons, Szandor, Xing, Na, Abdelgawad, Azza, Herwig, Susanne, Cichon, Günter, Niemeyer, Daniela, Drosten, Christian, Goffinet, Christine, Landthaler, Markus, Blüthgen, Nils, Wu, Haibo, Witzenrath, Martin, Gruber, Achim D., Praktiknjo, Samantha D., Osterrieder, Nikolaus, Wyler, Emanuel, Kunec, Dusan, Trimpert, Jakob

“…Vaccines play a critical role in combating the COVID-19 pandemic. Future control of the pandemic requires improved vaccines with high efficacy against newly…”
Get full text

Neural network-assisted humanisation of COVID-19 hamster transcriptomic data reveals matching severity states in human disease by Friedrich, Vincent D., Pennitz, Peter, Wyler, Emanuel, Adler, Julia M., Postmus, Dylan, Müller, Kristina, Teixeira Alves, Luiz Gustavo, Prigann, Julia, Pott, Fabian, Vladimirova, Daria, Hoefler, Thomas, Goekeri, Cengiz, Landthaler, Markus, Goffinet, Christine, Saliba, Antoine-Emmanuel, Scholz, Markus, Witzenrath, Martin, Trimpert, Jakob, Kirsten, Holger, Nouailles, Geraldine

“…Translating findings from animal models to human disease is essential for dissecting disease mechanisms, developing and testing precise therapeutic strategies…”
Get full text