Search Results - "Adla, Santosh Kumar"

Current approaches to facilitate improved drug delivery to the central nervous system by Markowicz-Piasecka, Magdalena, Darłak, Patrycja, Markiewicz, Agata, Sikora, Joanna, Kumar Adla, Santosh, Bagina, Sreelatha, Huttunen, Kristiina M.

“…[Display omitted] Although many pharmaceuticals have therapeutic potentials for central nervous system (CNS) diseases, few of these agents have been…”
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Comparative Modelling of Organic Anion Transporting Polypeptides: Structural Insights and Comparison of Binding Modes by Tonduru, Arun Kumar, Adla, Santosh Kumar, Huttunen, Kristiina M, Kronenberger, Thales, Poso, Antti

“…To better understand the functionality of organic anion transporting polypeptides (OATPs) and to design new ligands, reliable structural data of each OATP is…”
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Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP) by Markowicz-Piasecka, Magdalena, Huttunen, Johanna, Montaser, Ahmed, Adla, Santosh Kumar, Auriola, Seppo, Lehtonen, Marko, Huttunen, Kristiina M.

“…Efflux transporters, namely ATP-binding cassette (ABC), are one of the primary reasons for cancer chemoresistance and the clinical failure of chemotherapy…”
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Neurosteroids: Structure-Uptake Relationships and Computational Modeling of Organic Anion Transporting Polypeptides (OATP)1A2 by Adla, Santosh Kumar, Tonduru, Arun Kumar, Kronenberger, Thales, Kudova, Eva, Poso, Antti, Huttunen, Kristiina M

“…In this study, we investigated the delivery of synthetic neurosteroids into MCF-7 human breast adenocarcinoma cells via Organic Anionic Transporting…”
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Increased/Targeted Brain (Pro)Drug Delivery via Utilization of Solute Carriers (SLCs) by Huttunen, Johanna, Adla, Santosh Kumar, Markowicz-Piasecka, Magdalena, Huttunen, Kristiina M.

“…Membrane transporters have a crucial role in compounds’ brain drug delivery. They allow not only the penetration of a wide variety of different compounds to…”
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Strong Inhibitory Effect, Low Cytotoxicity and High Plasma Stability of Steroidal Inhibitors of N -Methyl-D-Aspartate Receptors With C-3 Amide Structural Motif by Adla, Santosh Kumar, Slavikova, Barbora, Chodounska, Hana, Vyklicky, Vojtech, Ladislav, Marek, Hubalkova, Pavla, Krausova, Barbora, Smejkalova, Tereza, Nekardova, Michaela, Smidkova, Marketa, Monincova, Lenka, Soucek, Radko, Vyklicky, Ladislav, Kudova, Eva

“…Herein, we report the synthesis, structure-activity relationship study, and biological evaluation of neurosteroid inhibitors of -methyl-D-aspartate receptors…”
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Novel inhibitors of bromodomain and extra-terminal domain trigger cell death in breast cancer cell lines by Rahnasto-Rilla, Minna, Puumalainen, Tatu, Karttunen, Vilma, Adla, Santosh Kumar, Lahtela-Kakkonen, Maija

“…[Display omitted] •Novel scaffolds for the development of the bromodomain and extra-terminal domain (BET) inhibitors.•Some compounds also inhibited Sirtuins…”
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Amino acid transporters in neurological disorders and neuroprotective effects of cysteine derivatives by Adla, Santosh Kumar, Virtanen, Heinileena, Thongsodsaeng, Thanavit, Huttunen, Kristiina M.

“…For most diseases and disorders occurring in the brain, the full causes behind them are yet unknown, but many show signs of dysfunction of amino acid…”
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Current Chemical, Biological, and Physiological Views in the Development of Successful Brain-Targeted Pharmaceutics by Markowicz-Piasecka, Magdalena, Markiewicz, Agata, Darłak, Patrycja, Sikora, Joanna, Adla, Santosh Kumar, Bagina, Sreelatha, Huttunen, Kristiina M.

“…One of the greatest challenges with successful pharmaceutical treatments of central nervous system (CNS) diseases is the delivery of drugs into their target…”
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5β-reduced neuroactive steroids as modulators of growth and viability of postnatal neurons and glia by Munawar Cheema, Marie, Macakova Kotrbova, Zuzana, Hrcka Krausova, Barbora, Adla, Santosh Kumar, Slavikova, Barbora, Chodounska, Hana, Kratochvil, Miroslav, Vondrasek, Jiri, Sedlak, David, Balastik, Martin, Kudova, Eva

“…Endogenous neurosteroids (NS) and their synthetic analogs, neuroactive steroids (NAS), are potentially useful drug-like compounds affecting the pathophysiology…”
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Targeting Glial Cells by Organic Anion-Transporting Polypeptide 1C1 (OATP1C1)-Utilizing l-Thyroxine-Derived Prodrugs by Tonduru, Arun Kumar, Maljaei, Seyed Hamed, Adla, Santosh Kumar, Anamea, Landry, Tampio, Janne, Králová, Adéla, Jalkanen, Aaro J, Espada, Catarina, Santos, Inês Falcato, Montaser, Ahmed B, Rautio, Jarkko, Kronenberger, Thales, Poso, Antti, Huttunen, Kristiina M

“…OATP1C1 (organic anion-transporting polypeptide 1C1) transports thyroid hormones, particularly thyroxine (T ), into human astrocytes. In this study, we…”
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Indole prenylation in alkaloid synthesis by Lindel, Thomas, Marsch, Nils, Adla, Santosh Kumar

“…Important biologically active indole alkaloids are decorated with prenyl (3,3-dimethylallyl) and tert-prenyl (1,1-dimethylallyl) groups. Covering the…”
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Altering distribution profile of palbociclib by its prodrugs by Järvinen, Juulia, Montaser, Ahmed B., Adla, Santosh Kumar, Leppänen, Jukka, Lehtonen, Marko, Vellonen, Kati-Sisko, Laitinen, Tuomo, Jalkanen, Aaro, Elmquist, William F., Timonen, Juri, Huttunen, Kristiina M., Rautio, Jarkko

“…Palbociclib, a cyclin-dependent kinase (CDK) 4/6 inhibitor, is currently used clinically for treating hormone receptor-positive and human epidermal growth…”
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Screening of novel 3α5β-neurosteroids for neuroprotective activity against glutamate- or NMDA-induced excitotoxicity by Smidkova, Marketa, Hajek, Miroslav, Adla, Santosh Kumar, Slavikova, Barbora, Chodounska, Hana, Matousova, Marika, Mertlikova-Kaiserova, Helena, Kudova, Eva

“…[Display omitted] •3α5β-Neurosteroids suppress both glutamate- and NMDA-induced excitotoxicity.•Ca2+ entry and consequent ROS release and caspase-3 activation…”
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Synthesis of carbocyclic analogs of dehydroaltenusin: identification of a stable inhibitor of calf DNA polymerase α by Kováčová, Silvia, Adla, Santosh Kumar, Maier, Lukáš, Babiak, Michal, Mizushina, Yoshiyuki, Paruch, Kamil

“…Syntheses of carbocyclic analogs of dehydroaltenusin tautomers are reported. Both target compounds, cDHA…”
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Doubly prenylated tryptamines: cytotoxicity, antimicrobial activity and cyclisation to the marine natural product flustramine A by Adla, Santosh Kumar, Sasse, Florenz, Kelter, Gerhard, Fiebig, Heinz-Herbert, Lindel, Thomas

“…The marine natural product flustramine A was synthesised via oxidative cyclisation of Nb-methylated 1-prenyl-2-tert-prenyl-6-bromotryptamine and subsequent…”
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Physicochemical and biological properties of novel amide-based steroidal inhibitors of NMDA receptors by Adla, Santosh Kumar, Slavikova, Barbora, Smidkova, Marketa, Tloustova, Eva, Svoboda, Martin, Vyklicky, Vojtech, Krausova, Barbora, Hubalkova, Pavla, Nekardova, Michaela, Holubova, Kristina, Vales, Karel, Budesinsky, Milos, Vyklicky, Ladislav, Chodounska, Hana, Kudova, Eva

“…[Display omitted] •Synthesis of new amide-based inhibitors of NMDA receptors.•Strong inhibitors of NMDA currents.•The Caco-2 assay was used to evaluate…”
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Diastereoselective Flexible Synthesis of Carbocyclic C‑Nucleosides by Maier, Lukáš, Khirsariya, Prashant, Hylse, Ondřej, Adla, Santosh Kumar, Černová, Lenka, Poljak, Michal, Krajčovičová, Soňa, Weis, Erik, Drápela, Stanislav, Souček, Karel, Paruch, Kamil

“…Carbocyclic C-nucleosides are quite rare. Our route enables flexible preparation of three classes of these nucleoside analogs from common precursors–properly…”
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