Search Results - "Adkins, Chris E."

Heterogeneous Blood-Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer by LOCKMAN, Paul R, MITTAPALLI, Rajendar K, SUYUN HUANG, PALMIERI, Diane, STEEG, Patricia S, SMITH, Quentin R, TASKAR, Kunal S, RUDRARAJU, Vinay, GRIL, Brunilde, BOHN, Kaci A, ADKINS, Chris E, ROBERTS, Amanda, THORSHEIM, Helen R, GAASCH, Julie A

“…Brain metastases of breast cancer appear to be increasing in incidence, confer significant morbidity, and threaten to compromise gains made in systemic…”
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Quantitative Fluorescence Microscopy Measures Vascular Pore Size in Primary and Metastatic Brain Tumors by Mittapalli, Rajendar K, Adkins, Chris E, Bohn, Kaci A, Mohammad, Afroz S, Lockman, Julie A, Lockman, Paul R

“…Tumors residing in the central nervous system (CNS) compromise the blood-brain barrier (BBB) via increased vascular permeability, with the magnitude of changes…”
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Characterization of passive permeability at the blood–tumor barrier in five preclinical models of brain metastases of breast cancer by Adkins, Chris E., Mohammad, Afroz S., Terrell-Hall, Tori B., Dolan, Emma L., Shah, Neal, Sechrest, Emily, Griffith, Jessica, Lockman, Paul R.

“…The blood–brain barrier (BBB) is compromised in brain metastases, allowing for enhanced drug permeation into brain. The extent and heterogeneity of BBB…”
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Inhibition of VEGF and Angiopoietin-2 to Reduce Brain Metastases of Breast Cancer Burden by Bohn, Kaci A, Adkins, Chris E, Nounou, Mohamed I, Lockman, Paul R

“…For metastases in the central nervous system, angiogenesis enhances metastatic potential and promotes progression. Primary factors which drive vessel growth…”
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Permeability changes and effect of chemotherapy in brain adjacent to tumor in an experimental model of metastatic brain tumor from breast cancer by Mohammad, Afroz S, Adkins, Chris E, Shah, Neal, Aljammal, Rawaa, Griffith, Jessica I G, Tallman, Rachel M, Jarrell, Katherine L, Lockman, Paul R

“…Brain tumor vasculature can be significantly compromised and leakier than that of normal brain blood vessels. Little is known if there are vascular…”
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P-glycoprotein mediated efflux limits substrate and drug uptake in a preclinical brain metastases of breast cancer model by Adkins, Chris E, Mittapalli, Rajendar K, Manda, Vamshi K, Nounou, Mohamed I, Mohammad, Afroz S, Terrell, Tori B, Bohn, Kaci A, Yasemin, Celik, Grothe, Tiffany R, Lockman, Julie A, Lockman, Paul R

“…The blood-brain barrier (BBB) is a specialized vascular interface that restricts the entry of many compounds into brain. This is accomplished through the…”
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Deception by obfuscation: Studnicki et al.’s retracted longitudinal cohort study of emergency room utilization following abortion by Upadhyay, Ushma D., Adkins, Chris E.

“…In November 2022, the anti-abortion advocacy group Alliance for Hippocratic Medicine filed a lawsuit against the U.S. Food and Drug Administration challenging…”
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Alterations in Pericyte Subpopulations Are Associated with Elevated Blood-Tumor Barrier Permeability in Experimental Brain Metastasis of Breast Cancer by Lyle, L Tiffany, Lockman, Paul R, Adkins, Chris E, Mohammad, Afroz Shareef, Sechrest, Emily, Hua, Emily, Palmieri, Diane, Liewehr, David J, Steinberg, Seth M, Kloc, Wojciech, Izycka-Swieszewska, Ewa, Duchnowska, Renata, Nayyar, Naema, Brastianos, Priscilla K, Steeg, Patricia S, Gril, Brunilde

“…The blood-brain barrier (BBB) is modified to a blood-tumor barrier (BTB) as a brain metastasis develops from breast or other cancers. We (i) quantified the…”
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Liposomal Irinotecan Accumulates in Metastatic Lesions, Crosses the Blood-Tumor Barrier (BTB), and Prolongs Survival in an Experimental Model of Brain Metastases of Triple Negative Breast Cancer by Mohammad, Afroz S., Griffith, Jessica I., Adkins, Chris E., Shah, Neal, Sechrest, Emily, Dolan, Emma L., Terrell-Hall, Tori B., Hendriks, Bart S., Lee, Helen, Lockman, Paul R.

“…Purpose The blood-tumor barrier (BTB) limits irinotecan distribution in tumors of the central nervous system. However, given that the BTB has increased passive…”
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Molecular determinants of blood-brain barrier permeation by Geldenhuys, Werner J, Mohammad, Afroz S, Adkins, Chris E, Lockman, Paul R

“…The blood-brain barrier (BBB) is a microvascular unit which selectively regulates the permeability of drugs to the brain. With the rise in CNS drug targets and…”
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Anti-cancer Antibody Trastuzumab-Melanotransferrin Conjugate (BT2111) for the Treatment of Metastatic HER2+ Breast Cancer Tumors in the Brain: an In-Vivo Study by Nounou, Mohamed Ismail, Adkins, Chris E., Rubinchik, Evelina, Terrell-Hall, Tori B., Afroz, Mohamed, Vitalis, Tim, Gabathuler, Reinhard, Tian, Mei Mei, Lockman, Paul R.

“…Purpose The ability of human melanotransferrin (hMTf) to carry a therapeutic concentration of trastuzumab (BTA) in the brain after conjugation (in the form of…”
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Paclitaxel-hyaluronic nanoconjugates prolong overall survival in a preclinical brain metastases of breast cancer model by Mittapalli, Rajendar K, Liu, Xinli, Adkins, Chris E, Nounou, Mohamed I, Bohn, Kaci A, Terrell, Tori B, Qhattal, Hussaini S, Geldenhuys, Werner J, Palmieri, Diane, Steeg, Patricia S, Smith, Quentin R, Lockman, Paul R

“…Brain (central nervous system; CNS) metastases pose a life-threatening problem for women with advanced metastatic breast cancer. It has recently been shown…”
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Impact of L-DOPA treatment on regional cerebral blood flow and metabolism in the basal ganglia in a rat model of Parkinson's disease by Ohlin, K. Elisabet, Sebastianutto, Irene, Adkins, Chris E., Lundblad, Cornelia, Lockman, Paul R., Cenci, M. Angela

“…Large increases in regional cerebral blood flow (rCBF) have been measured in patients with Parkinson's disease (PD) following the administration of L-DOPA, but…”
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NKTR-102 Efficacy versus irinotecan in a mouse model of brain metastases of breast cancer by Adkins, Chris E, Nounou, Mohamed I, Hye, Tanvirul, Mohammad, Afroz S, Terrell-Hall, Tori, Mohan, Neel K, Eldon, Michael A, Hoch, Ute, Lockman, Paul R

“…Brain metastases are an increasing problem in women with invasive breast cancer. Strategies designed to treat brain metastases of breast cancer, particularly…”
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Semi-automated rapid quantification of brain vessel density utilizing fluorescent microscopy by Bohn, Kaci A., Adkins, Chris E., Mittapalli, Rajendar K., Terrell-Hall, Tori B., Mohammad, Afroz S., Shah, Neal, Dolan, Emma L., Nounou, Mohamed I., Lockman, Paul R.

“…[Display omitted] Vascular density varies significantly between brain regions and between healthy and diseased tissue. However, current methods are arduous and…”
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Abstract 2080: Demonstration of casual relationship between blood-tumor barrier permeability changes and chemotherapeutic uptake and effect in brain micrometastases of breast cancer by Mohammad, Afroz Shareef, Adkins, Chris E., Dolan, Emma L., Terrell-Hall, Tori B., Lockman, Paul R.

“…Background: 10-16% of women with advanced breast cancer will develop symptomatic brain metastases, the survival rate of which is less than 2 years. When…”
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Modulation of the blood-tumor barrier to enhance drug delivery and efficacy for brain metastases by Blethen, Kathryn E, Arsiwala, Tasneem A, Fladeland, Ross A, Sprowls, Samuel A, Panchal, Dhruvi M, Adkins, Chris E, Kielkowski, Brooke N, Earp, Leland E, Glass, Morgan J, Pritt, Trenton A, Cabuyao, Yssabela M, Aulakh, Sonikpreet, Lockman, Paul R

“…Abstract The blood-brain barrier is the selectively permeable vasculature of the brain vital for maintaining homeostasis and neurological function. Low…”
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Nicotine and cotinine increases the brain penetration of saquinavir in rat by Manda, Vamshi K, Mittapalli, Rajendar K, Bohn, Kaci A, Adkins, Chris E, Lockman, Paul R

“…J. Neurochem. (2010) 115, 1495-1507. ABSTRACT: Endothelial tight junctions and efflux transporters of the blood-brain barrier (BBB) significantly limit brain…”
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Quantitative fluorescence microscopy provides high resolution imaging of passive diffusion and P-gp mediated efflux at the in vivo blood–brain barrier by Mittapalli, Rajendar K., Manda, Vamshi K., Bohn, Kaci A., Adkins, Chris E., Lockman, Paul R.

“…Quantitative fluorescence microscopy provides significant insight into various fields. A novel method to calculate the blood to brain transfer rates of the…”
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A novel preclinical method to quantitatively evaluate early-stage metastatic events at the murine blood-brain barrier by Adkins, Chris E, Nounou, Mohamed I, Mittapalli, Rajendar K, Terrell-Hall, Tori B, Mohammad, Afroz S, Jagannathan, Rajaganapathi, Lockman, Paul R

“…The observation that approximately 15% of women with disseminated breast cancer will develop symptomatic brain metastases combined with treatment guidelines…”
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