Search Results - "Adjou, KT"

Evaluation of Quinacrine Treatment for Prion Diseases by Barret, A, Tagliavini, F, Forloni, G, Bate, C, Salmona, M, Colombo, L, De Luigi, A, Limido, L, Suardi, S, Rossi, G, Auvré, F, Adjou, K T, Salès, N, Williams, A, Lasmézas, C, Deslys, J P

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BSE transmission to macaques by Lasmezas, C.I, Deslys, J.P, Demaimay, R, Adjou, I.T, Lamoury, F, Dormont, D, Robain, O, Ironside, J, Hauw, J.J

“…The recent description in the United Kingdom of a new variant of Creutzfeldt-Jacob disease (vCJD) with a unique clinicopathological presentation has raised…”
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A novel generation of heparan sulfate mimetics for the treatment of prion diseases by Adjou, Karim Tarik, Simoneau, Steve, Sales, Nicole, Lamoury, Francois, Dormont, Dominique, Papy-Garcia, Dulce, Barritault, Denis, Deslys, Jean-Philippe, Lasmezas, Corinne Ida

“…1 CEA, DSV/DRM, 18 route du Panorama, BP6, 92265 Fontenay aux Roses Cedex, France 2 OTR3 Sarl, 33 rue Pierre Brossolette, 94000 Créteil, France 3 Laboratoire…”
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Opposite Effects of Dextran Sulfate 500, the Polyene Antibiotic MS-8209, and Congo Red on Accumulation of the Protease-Resistant Isoform of PrP in the Spleens of Mice Inoculated Intraperitoneally with the Scrapie Agent by Beringue, V, Adjou, K T, Lamoury, F, Maignien, T, Deslys, J P, Race, R, Dormont, D

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Alpha-synuclein-immunoreactive deposits in human and animal prion diseases by HAÏK, S, PRIVAT, N, ADJOU, K. T, SAZDOVITCH, V, DORMONT, D, DUYCKAERTS, C, HAUW, J. J

“…Prion related disorders are associated with the accumulation of a misfolded isoform (PrPsc) of the host-encoded prion protein, PrP. There is strong evidence…”
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Late treatment with polyene antibiotics can prolong the survival time of scrapie-infected animals by Demaimay, R, Adjou, K T, Beringue, V, Demart, S, Lasmézas, C I, Deslys, J P, Seman, M, Dormont, D

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Strain specific and common pathogenic events in murine models of scrapie and bovine spongiform encephalopathy by Lasmezas, Corinne Ida, Deslys, Jean-Philippe, Demaimay, Remi, Adjou, Karim T, Hauw, Jean-Jacques, Dormont, Dominique

“…1 Service de Neurovirologie, DSV/DRM/CRSSA, Commissariat à l'Energie Atomique, 60-68 avenue Div. Leclerc, BP 6, 92 265 Fontenay-aux-Roses Cedex, France 2…”
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MS-8209, a water-soluble amphotericin B derivative, affects both scrapie agent replication and PrPres accumulation in Syrian hamster scrapie by Adjou, KT, Demaimay, R, Deslys, JP, Lasmezas, CI, Beringue, V, Demart, S, Lamoury, F, Seman, M, Dormont, D

“…KT Adjou, R Demaimay, JP Deslys, CI Lasmezas, V Beringue, S Demart, F Lamoury, M Seman and D Dormont CEA, Service de Neurovirologie, Fontenay aux Roses,…”
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MS-8209, a new amphotericin B derivative, provides enhanced efficacy in delaying hamster scrapie by KARIM TARIK ADJOU, DEMAIMAY, R, LASMEZAS, C, DESLYS, J.-P, SEMAN, M, DORMONT, D

“…To test the efficacy of a new amphotericin B derivative, MS-8209, in delaying scrapie, hamsters were infected intracerebrally with the 263K scrapie agent and…”
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MS-8209, amphotericin B analogue, delays the appearance of spongiosis, astrogliosis and PrPres accumulation in the brain of scrapie-infected hamsters by Adjou, K.T, Privat, N, Demart, S, Deslys, J.P, Seman, M, Hauw, J.J, Dormont, D

“…The histopathological response of scrapie-infected hamsters treated at the late stage of the infection with an "anti-scrapie" drug, a polyene macrolide…”
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Effects of MS-8209, an Amphotericin B Derivative, on Tumor Necrosis Factor Alpha Synthesis and Human Immunodeficiency Virus Replication in Macrophages by CLAYETTE, P, MARTIN, M, BERINGUE, V, DEREUDDRE-BOSQUET, N, ADJOU, K. T, SEMAN, M, DORMONT, D

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Inhibiting scrapie neuroinvasion by polyene antibiotic treatment of SCID mice by Beringue, V, Lasmezas, C.I, Adjou, K.T, Demaimay, R, Lamoury, F, Deslys, J.P, Seman, M, Dormont, D

“…The polyene antibiotic MS-8209 is currently one of the most effective drugs in the treatment of experimental scrapie. However, its mechanism of action and its…”
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Probing the dynamics of prion diseases with amphotericin B by Adjou, Karim Tarik, Deslys, Jean-Philippe, Demaimay, Rémi, Dormont, Dominique

“…Amphotericin B (AmB) is one of the rare drugs that affect the course of experimental prion diseases and modify the kinetics of abnormal prion protein…”
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Effects of the polyene antibiotic derivative MS-8209 on the astrocyte lysosomal system of scrapie-infected hamsters by Grigoriev, Vladimir B, Adjou, Karim T, Salès, Nicole, Simoneau, Steve, Deslys, Jean-Philippe, Seman, Michel, Dormont, Dominique, Fournier, Jean-Guy

“…Amphotericine B (AmB), a macrolide polyene antibiotic, is one of a few drugs that has shown therapeutic properties in scrapie-infected hamster. Its beneficial…”
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MS-8209, an Amphotericin B Analogue,Delays the Appearance of Spongiosis, Astrogliosis and PrPres Accumulation inthe Brain of Scrapie-infected Hamsters by Adjou, KT, Privat, N, Demart, S, Deslys, J -P, Seman, M, Hauw, J -J, Dormont, D

“…The histopathological response of scrapie-infected hamsters treated at the late stage of the infection with an “anti-scrapie” drug, a polyene macrolide…”
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Prospects for the pharmacological treatment of human prion diseases by ADJOU, K. T, DESLYS, J.-P, DEMAIMAY, R, SEMAN, M, DORMONT, D

“…There is currently no effective therapy available for Creutzfeldt-Jakob disease and related prion disorders. However, a limited number of drugs have been found…”
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Differential effects of a new amphotericin B derivative, MS-8209, on mouse bse and scrapie: implications for the mechanism of action of polyene antibiotics by Adjou, K.T., Demaimay, R., Lasmézas, C.I., Seman, M., Deslys, J.-P., Dormont, D.

“…Mice were infected intracerebrally with the bovine spongiform encephalopathy (BSE) or the scrapie agent and treated during 8 weeks postinfection to test the…”
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