Retrospective study of maternal HIV-1 and HIV-2 infections and child survival in Abidjan, Cote d'Ivoire
Objectives : To compare the effects of maternal HIV-1 and HIV-2 infections on outcome of pregnancy, infant mortality, and child survival, and to measure serological concordance between mothers and children. Design : Retrospective cohort study with cross sectional study of concordance for HIV antibod...
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Published in: | BMJ Vol. 308; no. 6926; pp. 441 - 443 |
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Main Authors: | , , , , , , , , , , |
Format: | Journal Article |
Language: | English |
Published: |
England
British Medical Journal Publishing Group
12-02-1994
British Medical Association BMJ Publishing Group LTD BMJ Group |
Subjects: | |
Online Access: | Get full text |
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Summary: | Objectives : To compare the effects of maternal HIV-1 and HIV-2 infections on outcome of pregnancy, infant mortality, and child survival, and to measure serological concordance between mothers and children. Design : Retrospective cohort study with cross sectional study of concordance for HIV antibodies. Setting - Hospital, tuberculosis clinic, and maternal and child health centre in Abidjan, Cote d'Ivoire, west Africa. Subjects : 986 women who had had a total of 2758 pregnancies since 1980. The last born children of 194 of these women. Main outcome measures : Pregnancy outcomes; mortality for all children born since 1980; and outcome for last born children. Serological concordance between mothers and last born children. Results : Women with HIV-1 and HIV-2 infections had higher rates of spontaneous abortion and stillbirth than uninfected women (86/769 in HIV-1 positive women, 48/421 in HIV-2 positive, 31/234 in dually reactive, and 96/1131 in uninfected). Compared with children born to uninfected mothers (mortality 10.3%), greater proportions of children of HIV-1 positive (20.6%) and dually reactive (20.3%) mothers had died; mortality in children of HIV-2 infected women (13.1%) was not significantly increased. Infant mortalities for the last born children of HIV-1 positive, dually reactive, HIV-2 positive, and seronegative women were, respectively, 133, 82, 32, and 40 per 1000 live births. Nine of 77 last born children of HIV-1 positive mothers were concordantly seropositive compared with none of 21 children of HIV-2 infected mothers. Conclusions : Maternal HIV-2 infection has less influence on child survival than infection with HIV-1, probably because of a lower vertical transmission rate. |
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Bibliography: | istex:EE12CAAF7CE86D626E6E60D6F538A1B8A90C7125 PMID:8124173 Correspondence to: Dr K M De Cock. href:bmj-308-441.pdf local:bmj;308/6926/441 ark:/67375/NVC-M5JPMS97-1 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0959-8138 1468-5833 1756-1833 |
DOI: | 10.1136/bmj.308.6926.441 |