Retrospective study of maternal HIV-1 and HIV-2 infections and child survival in Abidjan, Cote d'Ivoire

Objectives : To compare the effects of maternal HIV-1 and HIV-2 infections on outcome of pregnancy, infant mortality, and child survival, and to measure serological concordance between mothers and children. Design : Retrospective cohort study with cross sectional study of concordance for HIV antibod...

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Published in:BMJ Vol. 308; no. 6926; pp. 441 - 443
Main Authors: De Cock, K M, Zadi, F, Adjorolo, G, Diallo, M O, Sassan-Morokro, M, Ekpini, E, Sibailly, T, Doorly, R, Batter, V, Brattegaard, K, Gayle, H
Format: Journal Article
Language:English
Published: England British Medical Journal Publishing Group 12-02-1994
British Medical Association
BMJ Publishing Group LTD
BMJ Group
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Summary:Objectives : To compare the effects of maternal HIV-1 and HIV-2 infections on outcome of pregnancy, infant mortality, and child survival, and to measure serological concordance between mothers and children. Design : Retrospective cohort study with cross sectional study of concordance for HIV antibodies. Setting - Hospital, tuberculosis clinic, and maternal and child health centre in Abidjan, Cote d'Ivoire, west Africa. Subjects : 986 women who had had a total of 2758 pregnancies since 1980. The last born children of 194 of these women. Main outcome measures : Pregnancy outcomes; mortality for all children born since 1980; and outcome for last born children. Serological concordance between mothers and last born children. Results : Women with HIV-1 and HIV-2 infections had higher rates of spontaneous abortion and stillbirth than uninfected women (86/769 in HIV-1 positive women, 48/421 in HIV-2 positive, 31/234 in dually reactive, and 96/1131 in uninfected). Compared with children born to uninfected mothers (mortality 10.3%), greater proportions of children of HIV-1 positive (20.6%) and dually reactive (20.3%) mothers had died; mortality in children of HIV-2 infected women (13.1%) was not significantly increased. Infant mortalities for the last born children of HIV-1 positive, dually reactive, HIV-2 positive, and seronegative women were, respectively, 133, 82, 32, and 40 per 1000 live births. Nine of 77 last born children of HIV-1 positive mothers were concordantly seropositive compared with none of 21 children of HIV-2 infected mothers. Conclusions : Maternal HIV-2 infection has less influence on child survival than infection with HIV-1, probably because of a lower vertical transmission rate.
Bibliography:istex:EE12CAAF7CE86D626E6E60D6F538A1B8A90C7125
PMID:8124173
Correspondence to: Dr K M De Cock.
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ISSN:0959-8138
1468-5833
1756-1833
DOI:10.1136/bmj.308.6926.441