Search Results - "Adjemian, Sandy"

Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity by Wiernicki, Bartosz, Maschalidi, Sophia, Pinney, Jonathan, Adjemian, Sandy, Vanden Berghe, Tom, Ravichandran, Kodi S., Vandenabeele, Peter

“…Immunogenic cell death significantly contributes to the success of anti-cancer therapies, but immunogenicity of different cell death modalities widely varies…”
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Pattern Recognition Receptors and the Host Cell Death Molecular Machinery by Amarante-Mendes, Gustavo P, Adjemian, Sandy, Branco, Laura Migliari, Zanetti, Larissa C, Weinlich, Ricardo, Bortoluci, Karina R

“…Pattern Recognition Receptors (PRRs) are proteins capable of recognizing molecules frequently found in pathogens (the so-called Pathogen-Associated Molecular…”
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Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death by Adjemian, Sandy, Oltean, Teodora, Martens, Sofie, Wiernicki, Bartosz, Goossens, Vera, Vanden Berghe, Tom, Cappe, Benjamin, Ladik, Maria, Riquet, Franck B., Heyndrickx, Liesbeth, Bridelance, Jolien, Vuylsteke, Marnik, Vandecasteele, Katrien, Vandenabeele, Peter

“…Radiotherapy is commonly used as a cytotoxic treatment of a wide variety of tumors. Interestingly, few case reports underlined its potential to induce…”
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Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice by Michaud, Mickaël, Martins, Isabelle, Sukkurwala, Abdul Qader, Adjemian, Sandy, Ma, Yuting, Pellegatti, Patrizia, Shen, Shensi, Kepp, Oliver, Scoazec, Marie, Mignot, Grégoire, Rello-Varona, Santiago, Tailler, Maximilien, Menger, Laurie, Vacchelli, Erika, Galluzzi, Lorenzo, Ghiringhelli, François, di Virgilio, Francesco, Zitvogel, Laurence, Kroemer, Guido

“…Antineoplastic chemotherapies are particularly efficient when they elicit immunogenic cell death, thus provoking an anticancer immune response. Here we…”
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Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells by Ma, Yuting, Adjemian, Sandy, Mattarollo, Stephen R., Yamazaki, Takahiro, Aymeric, Laetitia, Yang, Heng, Portela Catani, João Paulo, Hannani, Dalil, Duret, Helene, Steegh, Kim, Martins, Isabelle, Schlemmer, Frederic, Michaud, Mickaël, Kepp, Oliver, Sukkurwala, Abdul Qader, Menger, Laurie, Vacchelli, Erika, Droin, Nathalie, Galluzzi, Lorenzo, Krzysiek, Roman, Gordon, Siamon, Taylor, Philip R., Van Endert, Peter, Solary, Eric, Smyth, Mark J., Zitvogel, Laurence, Kroemer, Guido

“…The therapeutic efficacy of anthracyclines relies on antitumor immune responses elicited by dying cancer cells. How chemotherapy-induced cell death leads to…”
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Cytoplasmic STAT3 Represses Autophagy by Inhibiting PKR Activity by Shen, Shensi, Niso-Santano, Mireia, Adjemian, Sandy, Takehara, Tetsuo, Malik, Shoaib Ahmad, Minoux, Hervé, Souquere, Sylvie, Mariño, Guillermo, Lachkar, Sylvie, Senovilla, Laura, Galluzzi, Lorenzo, Kepp, Oliver, Pierron, Gérard, Maiuri, Maria Chiara, Hikita, Hayato, Kroemer, Romano, Kroemer, Guido

“…In a screen designed to identify novel inducers of autophagy, we discovered that STAT3 inhibitors potently stimulate the autophagic flux. Accordingly, genetic…”
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Molecular determinants of immunogenic cell death elicited by anticancer chemotherapy by Kepp, Oliver, Galluzzi, Lorenzo, Martins, Isabelle, Schlemmer, Frederic, Adjemian, Sandy, Michaud, Mickael, Sukkurwala, Abdul Qader, Menger, Laurie, Zitvogel, Laurence, Kroemer, Guido

“…The success of some chemo- and radiotherapeutic regimens relies on the induction of immunogenic tumor cell death and on the induction of an anticancer immune…”
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Surface-exposed calreticulin in the interaction between dying cells and phagocytes by Martins, Isabelle, Kepp, Oliver, Galluzzi, Lorenzo, Senovilla, Laura, Schlemmer, Frederic, Adjemian, Sandy, Menger, Laurie, Michaud, Mickael, Zitvogel, Laurence, Kroemer, Guido

“…Phagocytosis is essential for pathogen elimination and for the removal of apoptotic corpses, a process that has been long considered immunologically silent…”
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Association of Cell Death Markers With Tumor Immune Cell Infiltrates After Chemo-Radiation in Cervical Cancer by Oltean, Teodora, Lippens, Lien, Lemeire, Kelly, De Tender, Caroline, Vuylsteke, Marnik, Denys, Hannelore, Vandecasteele, Katrien, Vandenabeele, Peter, Adjemian, Sandy

“…Irradiation induces distinct cellular responses such as apoptosis, necroptosis, iron-dependent cell death (a feature of ferroptosis), senescence, and mitotic…”
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Premortem autophagy determines the immunogenicity of chemotherapy-induced cancer cell death by Martins, Isabelle, Michaud, Mickaël, Sukkurwala, Abdul Qader, Adjemian, Sandy, Ma, Yuting, Shen, Shensi, Kepp, Oliver, Menger, Laurie, Vacchelli, Erika, Galluzzi, Lorenzo, Zitvogel, Laurence, Kroemer, Guido

“…One particular strategy to render anticancer therapies efficient consists of converting the patient's own tumor cells into therapeutic vaccines, via the…”
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Immunohistochemical detection of cytoplasmic LC3 puncta in human cancer specimens by Ladoire, Sylvain, Chaba, Kariman, Martins, Isabelle, Sukkurwala, Abdul Qader, Adjemian, Sandy, Michaud, Mickaël, Poirier-Colame, Vichnou, Andreiuolo, Felipe, Galluzzi, Lorenzo, White, Eileen, Rosenfeldt, Mathias, Ryan, Kevin M., Zitvogel, Laurence, Kroemer, Guido

“…Autophagy is an evolutionarily conserved catabolic process that involves the entrapment of cytoplasmic components within characteristic vesicles for their…”
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Chemokines and chemokine receptors required for optimal responses to anticancer chemotherapy by Ma, Yuting, Adjemian, Sandy, Galluzzi, Lorenzo, Zitvogel, Laurence, Kroemer, Guido

“…Depending on tumor type, stage and immunological contexture, the inhibition of chemokines or their receptors may yield positive or deleterious effects on…”
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Direct interaction between STAT3 and EIF2AK2 controls fatty acid-induced autophagy by Niso-Santano, Mireia, Shen, Shensi, Adjemian, Sandy, Malik, Shoaib Ahmad, Mariño, Guillermo, Lachkar, Sylvie, Senovilla, Laura, Kepp, Oliver, Galluzzi, Lorenzo, Maiuri, Maria Chiara, Kroemer, Guido

“…A chemical screen designed to identify novel inducers of autophagy led to the discovery that signal transducer and activator of transcription 3 (STAT3)…”
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Intratumoral Immunization by p19Arf and Interferon-β Gene Transfer in a Heterotopic Mouse Model of Lung Carcinoma by Catani, João Paulo Portela, Medrano, Ruan F.V, Hunger, Aline, Del Valle, Paulo, Adjemian, Sandy, Zanatta, Daniela Bertolini, Kroemer, Guido, Costanzi-Strauss, Eugenia, Strauss, Bryan E

“…Abstract Therapeutic strategies that act by eliciting and enhancing antitumor immunity have been clinically validated as an effective treatment modality but…”
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Near future of tumor immunology: Anticipating resistance mechanisms to immunotherapies, a big challenge for clinical trials by Catani, João Paulo Portela, Riechelmann, Rachel P., Adjemian, Sandy, Strauss, Bryan E.

“…The success of immunotherapies brings hope for the future of cancer treatment. Even so, we are faced with a new challenge, that of understanding which patients…”
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Disruption of the PP1/GADD34 complex induces calreticulin exposure by Kepp, Oliver, Galluzzi, Lorenzo, Giordanetto, Fabrizio, Tesniere, Antoine, Vitale, Ilio, Martins, Isabelle, Schlemmer, Frèdèric, Adjemian, Sandy, Zitvogel, Laurence, Kroemer, Guido

“…In response to some chemotherapeutic agents, tumor cells can translocate calreticulin (CRT), which is usually contained in the lumen of the endoplasmic…”
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Loss-of-function alleles of P2RX7 and TLR4 fail to affect the response to chemotherapy in non-small cell lung cancer by Vacchelli, Erika, Galluzzi, Lorenzo, Rousseau, Vanessa, Rigoni, Alice, Tesniere, Antoine, Delahaye, Nicolas, Schlemmer, Fre´de´ric, Menger, Laurie, Sukkurwala, Abdul Qader, Adjemian, Sandy, Martins, Isabelle, Michaud, Mickaël, Dunant, Ariane, Kepp, Oliver, Brambilla, Elisabeth, Soria, Jean-Charles, Zitvogel, Laurence, Kroemer, Guido

“…The success of anticancer chemotherapy relies at least in part on the induction of an immune response against tumor cells. Thus, tumors growing on mice that…”
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Crosstalk between ER stress and immunogenic cell death by Kepp, Oliver, Menger, Laurie, Vacchelli, Erika, Locher, Clara, Adjemian, Sandy, Yamazaki, Takahiro, Martins, Isabelle, Sukkurwala, Abdul Qader, Michaud, Michael, Senovilla, Laura, Galluzzi, Lorenzo, Kroemer, Guido, Zitvogel, Laurence

“…Abstract Preclinical and clinical findings suggest that tumor-specific immune responses may be responsible – at least in part – for the clinical success of…”
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Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1 by Vacchelli, Erika, Ma, Yuting, Baracco, Elisa E., Sistigu, Antonella, Enot, David P., Pietrocola, Federico, Yang, Heng, Adjemian, Sandy, Chaba, Kariman, Semeraro, Michaela, Signore, Michele, De Ninno, Adele, Lucarini, Valeria, Peschiaroli, Francesca, Businaro, Luca, Gerardino, Annamaria, Manic, Gwenola, Ulas, Thomas, Günther, Patrick, Schultze, Joachim L., Kepp, Oliver, Stoll, Gautier, Lefebvre, Céline, Mulot, Claire, Castoldi, Francesca, Rusakiewicz, Sylvie, Ladoire, Sylvain, Apetoh, Lionel, Pedro, José Manuel Bravo-San, Lucattelli, Monica, Delarasse, Cécile, Boige, Valérie, Ducreux, Michel, Delaloge, Suzette, Borg, Christophe, André, Fabrice, Schiavoni, Giovanna, Vitale, Ilio, Laurent-Puig, Pierre, Mattei, Fabrizio, Zitvogel, Laurence, Kroemer, Guido

“…Antitumor immunity driven by intratumoral dendritic cells contributes to the efficacy of anthracycline-based chemotherapy in cancer. We identified a…”
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Consensus guidelines for the definition, detection and interpretation of immunogenic cell death by Galluzzi, Lorenzo, Vitale, Ilio, Warren, Sarah, Adjemian, Sandy, Agostinis, Patrizia, Martinez, Aitziber Buqué, Chan, Timothy A, Coukos, George, Demaria, Sandra, Deutsch, Eric, Draganov, Dobrin, Edelson, Richard L, Formenti, Silvia C, Fucikova, Jitka, Gabriele, Lucia, Gaipl, Udo S, Gameiro, Sofia R, Garg, Abhishek D, Golden, Encouse, Han, Jian, Harrington, Kevin J, Hemminki, Akseli, Hodge, James W, Hossain, Dewan Md Sakib, Illidge, Tim, Karin, Michael, Kaufman, Howard L, Kepp, Oliver, Kroemer, Guido, Lasarte, Juan Jose, Loi, Sherene, Lotze, Michael T, Manic, Gwenola, Merghoub, Taha, Melcher, Alan A, Mossman, Karen L, Prosper, Felipe, Rekdal, Øystein, Rescigno, Maria, Riganti, Chiara, Sistigu, Antonella, Smyth, Mark J, Spisek, Radek, Stagg, John, Strauss, Bryan E, Tang, Daolin, Tatsuno, Kazuki, van Gool, Stefaan W, Vandenabeele, Peter, Yamazaki, Takahiro, Zamarin, Dmitriy, Zitvogel, Laurence, Cesano, Alessandra, Marincola, Francesco M

“…Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display…”
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