Search Results - "Adissu, Hibret A."

Naturally Occurring Canine Melanoma as a Predictive Comparative Oncology Model for Human Mucosal and Other Triple Wild-Type Melanomas by Hernandez, Belen, Adissu, Hibret A, Wei, Bih-Rong, Michael, Helen T, Merlino, Glenn, Simpson, R Mark

“…Melanoma remains mostly an untreatable fatal disease despite advances in decoding cancer genomics and developing new therapeutic modalities. Progress in…”
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Polymer–lipid hybrid nanoparticles synchronize pharmacokinetics of co-encapsulated doxorubicin–mitomycin C and enable their spatiotemporal co-delivery and local bioavailability in breast tumor by Zhang, Rui Xue, MSc, Cai, Ping, MD, Zhang, Tian, BSc, Chen, King, BSc in Pharmacy, Li, Jason, MASc, Cheng, Ji, PhD, Pang, K. Sandy, Prof. PhD, Adissu, Hibret A., DVM, PhD, DACVP, Rauth, Andrew M., Prof. PhD, Wu, Xiao Yu, Prof. PhD

“…Abstract Effective combination chemotherapy requires the delivery of drugs of synergistic activities to tumor sites while sparing normal tissues. Herein we…”
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Tankyrase represses autoinflammation through the attenuation of TLR2 signaling by Matsumoto, Yoshinori, Dimitriou, Ioannis D, La Rose, Jose, Lim, Melissa, Camilleri, Susan, Law, Napoleon, Adissu, Hibret A, Tong, Jiefei, Moran, Michael F, Chruscinski, Andrzej, He, Fang, Asano, Yosuke, Katsuyama, Takayuki, Sada, Ken-Ei, Wada, Jun, Rottapel, Robert

“…Dysregulation of Toll-like receptor (TLR) signaling contributes to the pathogenesis of autoimmune diseases. Here, we provide genetic evidence that tankyrase, a…”
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Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism by Matsumoto, Yoshinori, La Rose, Jose, Lim, Melissa, Adissu, Hibret A, Law, Napoleon, Mao, Xiaohong, Cong, Feng, Mera, Paula, Karsenty, Gerard, Goltzman, David, Changoor, Adele, Zhang, Lucia, Stajkowski, Megan, Grynpas, Marc D, Bergmann, Carsten, Rottapel, Robert

“…Cleidocranial dysplasia (CCD) is an autosomal dominant human disorder characterized by abnormal bone development that is mainly due to defective…”
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Efficacy, Tolerability, and Pharmacokinetics of Combined Targeted MEK and Dual mTORC1/2 Inhibition in a Preclinical Model of Mucosal Melanoma by Wei, Bih-Rong, Hoover, Shelley B, Peer, Cody J, Dwyer, Jennifer E, Adissu, Hibret A, Shankarappa, Priya, Yang, Howard, Lee, Maxwell, Peat, Tyler J, Figg, William D, Simpson, R Mark

“…Melanomas arising in the mucous membranes are a rare and aggressive subtype. New treatment approaches are needed, yet accumulating sufficient evidence to…”
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The voltage‐gated proton channel Hv1/VSOP inhibits neutrophil granule release by Okochi, Yoshifumi, Aratani, Yasuaki, Adissu, Hibret A., Miyawaki, Nana, Sasaki, Mari, Suzuki, Kazuo, Okamura, Yasushi

“…Hv1/VSOP regulates the production of HOCl and degradative enzymes through the inhibition of release of azurophilic granules in neutrophils. Neutrophil granule…”
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Biocompatible and bioactivable terpolymer-lipid-MnO2 Nanoparticle-based MRI contrast agent for improving tumor detection and delineation by Yen, Tin-Yo C., Abbasi, Azhar Z., He, Chungsheng, Lip, Ho-Yin, Park, Elliya, Amini, Mohammad A., Adissu, Hibret A., Foltz, Warren, Rauth, Andrew M., Henderson, Jeffrey, Wu, Xiao Yu

“…Early and precise detection of solid tumor cancers is critical for improving therapeutic outcomes. In this regard, magnetic resonance imaging (MRI) has become…”
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Zygotic Porcn paternal allele deletion in mice to model human focal dermal hypoplasia by Biechele, Steffen, Adissu, Hibret A, Cox, Brian J, Rossant, Janet

“…In mouse and humans, the X-chromosomal Porcupine homolog (Porcn) gene is required for the acylation and secretion of all 19 Wnt ligands, thus representing a…”
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Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen by Adissu, Hibret A, Estabel, Jeanne, Sunter, David, Tuck, Elizabeth, Hooks, Yvette, Carragher, Damian M, Clarke, Kay, Karp, Natasha A, Newbigging, Susan, Jones, Nora, Morikawa, Lily, White, Jacqueline K, McKerlie, Colin

“…The Mouse Genetics Project (MGP) at the Wellcome Trust Sanger Institute aims to generate and phenotype over 800 genetically modified mouse lines over the next…”
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The Price of “Humanization” by Adissu, Hibret A.

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Factors necessary to produce basoapical polarity in human glandular epithelium formed in conventional and high-throughput three-dimensional culture: example of the breast epithelium by Plachot, Cedric, Chaboub, Lesley S, Adissu, Hibret A, Wang, Lei, Urazaev, Albert, Sturgis, Jennifer, Asem, Elikplimi K, Lelièvre, Sophie A

“…Basoapical polarity in epithelia is critical for proper tissue function, and control of proliferation and survival. Cell culture models that recapitulate…”
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Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling by Louria-Hayon, Igal, Frelin, Catherine, Ruston, Julie, Gish, Gerald, Jin, Jing, Kofler, Michael M., Lambert, Jean-Philippe, Adissu, Hibret A., Milyavsky, Michael, Herrington, Robert, Minden, Mark D., Dick, John E., Gingras, Anne-Claude, Iscove, Norman N., Pawson, Tony

“…The Lnk (Sh2b3) adaptor protein dampens the response of hematopoietic stem cells and progenitors (HSPCs) to a variety of cytokines by inhibiting JAK2…”
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Proteotyping of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma by Mohammed, Yassene, Michaud, Sarah A., Pětrošová, Helena, Yang, Juncong, Ganguly, Milan, Schibli, David, Flenniken, Ann M., Nutter, Lauryl M. J., Adissu, Hibret A., Lloyd, K. C. Kent, McKerlie, Colin, Borchers, Christoph H.

“…We proteotyped blood plasma from 30 mouse knockout strains and corresponding wild-type mice from the International Mouse Phenotyping Consortium. We used…”
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The epithelial polarity axis controls the resting membrane potential and Cl- co-transport in breast glandular structures by Urazaev, Albert K, Wang, Lei, Bai, Yunfeng, Adissu, Hibret A, Lelièvre, Sophie A

“…The membrane potential (MP) controls cell homeostasis by directing molecule transport and gene expression. How the MP is set upon epithelial differentiation is…”
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Digital Microscopy, Image Analysis, and Virtual Slide Repository by Aeffner, Famke, Adissu, Hibret A, Boyle, Michael C, Cardiff, Robert D, Hagendorn, Erik, Hoenerhoff, Mark J, Klopfleisch, Robert, Newbigging, Susan, Schaudien, Dirk, Turner, Oliver, Wilson, Kristin

“…Advancements in technology and digitization have ushered in novel ways of enhancing tissue-based research via digital microscopy and image analysis. Whole…”
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Timp3 loss accelerates tumour invasion and increases prostate inflammation in a mouse model of prostate cancer by Adissu, Hibret A., McKerlie, Colin, Di Grappa, Marco, Waterhouse, Paul, Xu, Qiang, Fang, Hui, Khokha, Rama, Wood, Geoffrey A.

“…BACKGROUND Altered expression and activity of proteases is implicated in inflammation and cancer progression. An important negative regulator of protease…”
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Special focus on SARS-CoV-2 and other zoonotic respiratory coronaviruses in animal models by Adissu, Hibret A., Meyerholz, David K., Martinot, Amanda J., Ward, Jerrold M.

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A Case of Bilateral Auricular Chondritis in a Heifer by Adissu, Hibret A., Baird, John D., Wood, Geoffrey A.

“…Auricular chondritis is an extremely rare condition in cattle and other domestic animals. A 13-month-old Jersey heifer was presented with cutaneous…”
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MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat‐induced steatosis by Podrini, Christine, Koffas, Apostolos, Chokshi, Shilpa, Vinciguerra, Manlio, Lelliott, Christopher J., White, Jacqueline K., Adissu, Hibret A., Williams, Roger, Greco, Azzura

“…ABSTRACT The importance of epigenetic changes in the development of hepatic steatosis is largely unknown. The histone variant macroH2A1 under alternative…”
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Exclusion of Expert Contributors From Authorship Limits the Quality of Scientific Articles by Meyerholz, David K., Adissu, Hibret A., Carvalho, Tania, Atkins, Hannah M., Rissi, Daniel R., Beck, Amanda P., Ward, Jerrold M., Piersigilli, Alessandra

“…Veterinary pathologists are key contributors to multidisciplinary biomedical research. However, they are occasionally excluded from authorship in published…”
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