Search Results - "Adinolfi, Simone"

The KEAP1-NRF2 pathway: Targets for therapy and role in cancer by Adinolfi, Simone, Patinen, Tommi, Jawahar Deen, Ashik, Pitkänen, Sini, Härkönen, Jouni, Kansanen, Emilia, Küblbeck, Jenni, Levonen, Anna-Liisa

“…The KEAP1-NRF2 pathway is the key regulator of cellular defense against both extrinsic and intrinsic oxidative and electrophilic stimuli. Since its discovery…”
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Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy by Iannotti, Fabio A., Pagano, Ester, Guardiola, Ombretta, Adinolfi, Simone, Saccone, Valentina, Consalvi, Silvia, Piscitelli, Fabiana, Gazzerro, Elisabetta, Busetto, Giuseppe, Carrella, Diego, Capasso, Raffaele, Puri, Pier Lorenzo, Minchiotti, Gabriella, Di Marzo, Vincenzo

“…The endocannabinoid system refers to a widespread signaling system and its alteration is implicated in a growing number of human diseases. However, the…”
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Regulation of stress signaling pathways by protein lipoxidation by Patinen, Tommi, Adinolfi, Simone, Cortés, Carlos Cruz, Härkönen, Jouni, Jawahar Deen, Ashik, Levonen, Anna-Liisa

“…Enzymatic and non-enzymatic oxidation of unsaturated fatty acids gives rise to reactive species that covalently modify nucleophilic residues within redox…”
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PI3Kβ inhibition enhances ALK‐inhibitor sensitivity in ALK‐rearranged lung cancer by Talwelkar, Sarang S., Mäyränpää, Mikko I., Schüler, Julia, Linnavirta, Nora, Hemmes, Annabrita, Adinolfi, Simone, Kankainen, Matti, Sommergruber, Wolfgang, Levonen, Anna‐Liisa, Räsänen, Jari, Knuuttila, Aija, Verschuren, Emmy W., Wennerberg, Krister

“…Treatment with anaplastic lymphoma kinase (ALK) inhibitors significantly improves outcome for non‐small‐cell lung cancer (NSCLC) patients with ALK‐rearranged…”
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Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells by Deen, Ashik Jawahar, Adinolfi, Simone, Härkönen, Jouni, Patinen, Tommi, Liu, Xiaonan, Laitinen, Tuomo, Takabe, Piia, Kainulainen, Kirsi, Pasonen-Seppänen, Sanna, Gawriyski, Lisa M., Arasu, Uma Thanigai, Selvarajan, Ilakya, Mäkinen, Petri, Laitinen, Hanna, Kansanen, Emilia, Kaikkonen, Minna U., Poso, Antti, Varjosalo, Markku, Levonen, Anna-Liisa

“…The Kelch-like ECH-associated protein 1 (KEAP1) – Nuclear factor erythroid 2 -related factor 2 (NRF2) pathway is the major transcriptional stress response…”
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Regulation of stress signaling pathways by nitro-fatty acids by Deen, Ashik Jawahar, Sihvola, Virve, Härkönen, Jouni, Patinen, Tommi, Adinolfi, Simone, Levonen, Anna-Liisa

“…Electrophilic nitrated-fatty acids (NO2-FA, nitroalkenes) are formed during reactions of NO-derived oxidized species (•NO, •NO2) with either free or esterified…”
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Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolaemic mice by Ruotsalainen, Anna-Kaisa, Lappalainen, Jari P, Heiskanen, Emmi, Merentie, Mari, Sihvola, Virve, Näpänkangas, Juha, Lottonen-Raikaslehto, Line, Kansanen, Emilia, Adinolfi, Simone, Kaarniranta, Kai, Ylä-Herttuala, Seppo, Jauhiainen, Matti, Pirinen, Eija, Levonen, Anna-Liisa

“…Abstract Aims Oxidative stress and inflammation play an important role in the progression of atherosclerosis. Transcription factor NF-E2-related factor 2…”
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PI3Kβ inhibition enhances ALK#8208;inhibitor sensitivity in ALK#8208;rearranged lung cancer by Talwelkar, Sarang S, Mäyränpää, Mikko I, Schüler, Julia, Linnavirta, Nora, Hemmes, Annabrita, Adinolfi, Simone, Kankainen, Matti, Sommergruber, Wolfgang, Levonen, Anna‐Liisa, Räsänen, Jari, Knuuttila, Aija, Verschuren, Emmy W, Wennerberg, Krister

“…Treatment with anaplastic lymphoma kinase (ALK) inhibitors significantly improves outcome for non‐small‐cell lung cancer (NSCLC) patients with ALK‐rearranged…”
Get full text