Search Results - "Adhireksan, Zenita"

Near-atomic resolution structures of interdigitated nucleosome fibres by Adhireksan, Zenita, Sharma, Deepti, Lee, Phoi Leng, Davey, Curt A.

“…Chromosome structure at the multi-nucleosomal level has remained ambiguous in spite of its central role in epigenetic regulation and genome dynamics. Recent…”
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Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activity by Adhireksan, Zenita, Davey, Gabriela E., Campomanes, Pablo, Groessl, Michael, Clavel, Catherine M., Yu, Haojie, Nazarov, Alexey A., Yeo, Charmian Hui Fang, Ang, Wee Han, Dröge, Peter, Rothlisberger, Ursula, Dyson, Paul J., Davey, Curt A.

“…Ruthenium compounds have become promising alternatives to platinum drugs by displaying specific activities against different cancers and favourable toxicity…”
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Allosteric cross-talk in chromatin can mediate drug-drug synergy by Adhireksan, Zenita, Palermo, Giulia, Riedel, Tina, Ma, Zhujun, Muhammad, Reyhan, Rothlisberger, Ursula, Dyson, Paul J., Davey, Curt A.

“…Exploitation of drug–drug synergism and allostery could yield superior therapies by capitalizing on the immensely diverse, but highly specific, potential…”
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Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation by Davey, Gabriela E., Adhireksan, Zenita, Ma, Zhujun, Riedel, Tina, Sharma, Deepti, Padavattan, Sivaraman, Rhodes, Daniela, Ludwig, Alexander, Sandin, Sara, Murray, Benjamin S., Dyson, Paul J., Davey, Curt A.

“…The ‘acidic patch’ is a highly electronegative cleft on the histone H2A–H2B dimer in the nucleosome. It is a fundamental motif for protein binding and…”
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A Ruthenium Antimetastasis Agent Forms Specific Histone Protein Adducts in the Nucleosome Core by Wu, Bin, Ong, Michelle S., Groessl, Michael, Adhireksan, Zenita, Hartinger, Christian G., Dyson, Paul J., Davey, Curt A.

“…His‐tones are not ruth‐less: A ruthenium anticancer agent, RAPTA‐C, was found to associate with chromatin in cancer cells and to form stable, well‐defined…”
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Engineering nucleosomes for generating diverse chromatin assemblies by Adhireksan, Zenita, Sharma, Deepti, Lee, Phoi Leng, Bao, Qiuye, Padavattan, Sivaraman, Shum, Wayne K, Davey, Gabriela E, Davey, Curt A

“…Abstract Structural characterization of chromatin is challenging due to conformational and compositional heterogeneity in vivo and dynamic properties that…”
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Crosslinking Allosteric Sites on the Nucleosome by Batchelor, Lucinda K., De Falco, Louis, Erlach, Thibaud, Sharma, Deepti, Adhireksan, Zenita, Roethlisberger, Ursula, Davey, Curt A., Dyson, Paul J.

“…Targeting defined histone protein sites in chromatin is an emerging therapeutic approach that can potentially be enhanced by allosteric effects within the…”
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X-ray crystallographic analysis of the chromatosome by Padavattan, Sivaraman, Adhireksan, Zenita, Bao, Qiuye, Davey, Curt A.

“…Abstract only…”
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X-ray crystal structure of a chromatosome by Davey, Curt A., Adhireksan, Zenita, Bao, Qiuye, Padavattan, Sivaraman

“…Abstract only…”
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An Organometallic Compound which Exhibits a DNA Topology-Dependent One-Stranded Intercalation Mode by Ma, Zhujun, Palermo, Giulia, Adhireksan, Zenita, Murray, Benjamin S., von Erlach, Thibaud, Dyson, Paul J., Rothlisberger, Ursula, Davey, Curt A.

“…Understanding how small molecules interact with DNA is essential since it underlies a multitude of pathological conditions and therapeutic interventions. Many…”
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Targeting epigenetic vulnerabilities of cancer cells by exploiting chromatin structure and chemistry by Adhireksan, Zenita, Davey, Gabriela E., Ma, Zhujun, Palermo, Giulia, Riedel, Tina, Murray, Benjamin S., Nazarov, Alexey A., Hartinger, Christian G., Röthlisberger, Ursula, Dyson, Paul J., Davey, Curt A.

“…Abstract only…”
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Functionalization of Ruthenium(II)(η6‐p‐cymene)(3‐hydroxy‐2‐pyridone) Complexes with (Thio)Morpholine: Synthesis and Bioanalytical Studies by Hanif, Muhammad, Meier, Samuel M., Adhireksan, Zenita, Henke, Helena, Martic, Sanela, Movassaghi, Sanam, Labib, Mahmoud, Kandioller, Wolfgang, Jamieson, Stephen M. F., Hejl, Michaela, Jakupec, Michael A., Kraatz, Heinz‐Bernhard, Davey, Curt A., Keppler, Bernhard K., Hartinger, Christian G.

“…Hydroxypyr(id)ones constitute an emerging platform for the design of drug molecules, owing to their favorable biocompatibility and toxicity profiles. Herein,…”
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Back Cover: Functionalization of Ruthenium(II)(η6‐p‐cymene)(3‐hydroxy‐2‐pyridone) Complexes with (Thio)Morpholine: Synthesis and Bioanalytical Studies (ChemPlusChem 6/2017) by Hanif, Muhammad, Meier, Samuel M., Adhireksan, Zenita, Henke, Helena, Martic, Sanela, Movassaghi, Sanam, Labib, Mahmoud, Kandioller, Wolfgang, Jamieson, Stephen M. F., Hejl, Michaela, Jakupec, Michael A., Kraatz, Heinz‐Bernhard, Davey, Curt A., Keppler, Bernhard K., Hartinger, Christian G.

“…The cover picture shows the crystal structure formed from a {RuII(η6‐p‐cymene)} complex featuring a thiomorpholine substituent and the nucleosome core…”
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Crosslinking Allosteric Sites on the Nucleosome by Batchelor, Lucinda K., De Falco, Louis, Erlach, Thibaud, Sharma, Deepti, Adhireksan, Zenita, Roethlisberger, Ursula, Davey, Curt A., Dyson, Paul J.

“…Targeting defined histone protein sites in chromatin is an emerging therapeutic approach that can potentially be enhanced by allosteric effects within the…”
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An Organometallic Compound which Exhibits a DNA Topology-Dependent One-Stranded Intercalation Mode by Ma, Zhujun, Palermo, Giulia, Adhireksan, Zenita, Murray, Benjamin S., von Erlach, Thibaud, Dyson, Paul J., Rothlisberger, Ursula, Davey, Curt A.

“…Understanding how small molecules interact with DNA is essential since it underlies a multitude of pathological conditions and therapeutic interventions. Many…”
Get full text