Search Results - "Adhikari, Neill K"

Intensive care unit capacity in low-income countries: a systematic review by Murthy, Srinivas, Leligdowicz, Aleksandra, Adhikari, Neill K J

“…Access to critical care is a crucial component of healthcare systems. In low-income countries, the burden of critical illness is substantial, but the capacity…”
Get full text

Critical care and the global burden of critical illness in adults by Adhikari, Neill KJ, MD, Fowler, Robert A, MD, Bhagwanjee, Satish, Prof, Rubenfeld, Gordon D, Dr, Prof

“…Summary Critical care has evolved from treatment of poliomyelitis victims with respiratory failure in an intensive care unit to treatment of severely ill…”
Get full text

What is an Intensive Care Unit (ICU): A Report of the Task Force of the World Federation of Societies of Intensive and Critical Care Medicine by Marshall, John C., MD, Bosco, Laura, BSc, Adhikari, Neill K., MDCM, Connolly, Bronwen, PhD, Diaz, Janet V., MD, Dorman, Todd, MD, Fowler, Robert A., MD, Meyfroidt, Geert, MD, Nakagawa, Satoshi, MD, Pelosi, Paolo, MD, Vincent, Jean-Louis, MD, PhD, Vollman, Kathleen, RN, Zimmerman, Janice, MD

“…Abstract Since their widespread introduction more than half a century ago, Intensive Care Units (ICUs) have become an integral part of the health care system…”
Get full text

Vitamin C for Patients Hospitalized With COVID-19—Reply by Adhikari, Neill K. J, Lamontagne, Francois

Get full text

Comparative Effectiveness of Protective Ventilation Strategies for Moderate and Severe Acute Respiratory Distress Syndrome. A Network Meta-Analysis by Sud, Sachin, Friedrich, Jan O., Adhikari, Neill K. J., Fan, Eddy, Ferguson, Niall D., Guyatt, Gordon, Meade, Maureen O.

“…Sud et al. discuss the comparative effectiveness of protective ventilation strategies for moderate and severe acute respiratory distress syndrome. The authors…”
Get full text

Sepsis: a roadmap for future research by Cohen, Jonathan, Prof, Vincent, Jean-Louis, Prof, Adhikari, Neill K J, MDCM, Machado, Flavia R, MD, Angus, Derek C, Prof, Calandra, Thierry, Prof, Jaton, Katia, PhD, Giulieri, Stefano, MD, Delaloye, Julie, MD-PhD, Opal, Steven, Prof, Tracey, Kevin, Prof, van der Poll, Tom, Prof, Pelfrene, Eric, FRCP

“…Summary Sepsis is a common and lethal syndrome: although outcomes have improved, mortality remains high. No specific anti-sepsis treatments exist; as such,…”
Get full text

Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia: systematic review and meta-analysis by Sud, Sachin, Friedrich, Jan O., Taccone, Paolo, Polli, Federico, Adhikari, Neill K. J., Latini, Roberto, Pesenti, Antonio, Guérin, Claude, Mancebo, Jordi, Curley, Martha A. Q., Fernandez, Rafael, Chan, Ming-Cheng, Beuret, Pascal, Voggenreiter, Gregor, Sud, Maneesh, Tognoni, Gianni, Gattinoni, Luciano

“…Background Prone position ventilation for acute hypoxemic respiratory failure (AHRF) improves oxygenation but not survival, except possibly when AHRF is…”
Get full text

Oxygenation Response to Positive End-Expiratory Pressure Predicts Mortality in Acute Respiratory Distress Syndrome: A Secondary Analysis of the LOVS and ExPress Trials by GOLIGHER, Ewan C, KAVANAGH, Brian P, CHRETIEN, Jean-Marie, JONES, Graham L, COOK, Deborah J, STEWART, Thomas E, SLUTSKY, Arthur S, MEADE, Maureen O, FERGUSON, Niall D, RUBENFELD, Gordon D, ADHIKARI, Neill K. J, PINTO, Ruxandra, FAN, Eddy, BROCHARD, Laurent J, GRANTON, John T, MERCAT, Alain, RICHARD, Jean-Christophe Marie

“…Previous trials of higher positive end-expiratory pressure (PEEP) for acute respiratory distress syndrome (ARDS) failed to demonstrate mortality benefit,…”
Get full text

Falsifiability in medicine: what clinicians can learn from Karl Popper by Taran, Shaurya, Adhikari, Neill K. J., Fan, Eddy

Get full text

Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations by Fleischmann, Carolin, Scherag, André, Adhikari, Neill K J, Hartog, Christiane S, Tsaganos, Thomas, Schlattmann, Peter, Angus, Derek C, Reinhart, Konrad

“…Reducing the global burden of sepsis, a recognized global health challenge, requires comprehensive data on the incidence and mortality on a global scale. To…”
Get full text

Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis by Burry, Lisa D., Cheng, Wei, Williamson, David R., Adhikari, Neill K., Egerod, Ingrid, Kanji, Salmaan, Martin, Claudio M., Hutton, Brian, Rose, Louise

“…Purpose To compare the effects of prevention interventions on delirium occurrence in critically ill adults. Methods MEDLINE, Embase, PsychINFO, CINAHL, Web of…”
Get full text

Striving for perfection: navigating the complexity of extracorporeal membrane oxygenation and positioning in acute respiratory distress syndrome treatment. Author’s reply by Sud, Sachin, Adhikari, Neill K. J., Friedrich, Jan O., Fan, Eddy, Ferguson, Niall D.

Get full text

Psychological Consequences of Admission to the ICU: Helping Patients and Families by Rose, Louise, Muttalib, Fiona, Adhikari, Neill K. J

Get full text

Rate and risk factors for rehospitalisation in sepsis survivors: systematic review and meta-analysis by Shankar-Hari, Manu, Saha, Rohit, Wilson, Julie, Prescott, Hallie C., Harrison, David, Rowan, Kathryn, Rubenfeld, Gordon D., Adhikari, Neill K. J.

“…Purpose Sepsis survivors have a higher risk of rehospitalisation and of long-term mortality. We assessed the rate, diagnosis, and independent predictors for…”
Get full text

Correction to: Falsifiability in medicine: what clinicians can learn from Karl Popper by Taran, Shaurya, Adhikari, Neill K. J., Fan, Eddy

“…A correction to this paper has been published: https://doi.org/10.1007/s00134-021-06457-4…”
Get full text

Current challenges in the management of sepsis in ICUs in resource-poor settings and suggestions for the future by Schultz, Marcus J., Dunser, Martin W., Dondorp, Arjen M., Adhikari, Neill K. J., Iyer, Shivakumar, Kwizera, Arthur, Lubell, Yoel, Papali, Alfred, Pisani, Luigi, Riviello, Beth D., Angus, Derek C., Azevedo, Luciano C., Baker, Tim, Diaz, Janet V., Festic, Emir, Haniffa, Rashan, Jawa, Randeep, Jacob, Shevin T., Kissoon, Niranjan, Lodha, Rakesh, Martin-Loeches, Ignacio, Lundeg, Ganbold, Misango, David, Mer, Mervyn, Mohanty, Sanjib, Murthy, Srinivas, Musa, Ndidiamaka, Nakibuuka, Jane, Serpa Neto, Ary, Nguyen Thi Hoang, Mai, Nguyen Thien, Binh, Pattnaik, Rajyabardhan, Phua, Jason, Preller, Jacobus, Povoa, Pedro, Ranjit, Suchitra, Talmor, Daniel, Thevanayagam, Jonarthan, Thwaites, C. Louise

“…Background Sepsis is a major reason for intensive care unit (ICU) admission, also in resource-poor settings. ICUs in low- and middle-income countries (LMICs)…”
Get full text

Barriers and facilitators to the conduct of critical care research in low and lower-middle income countries: A scoping review by Tirupakuzhi Vijayaraghavan, Bharath Kumar, Gupta, Ena, Ramakrishnan, Nagarajan, Beane, Abi, Haniffa, Rashan, Lone, Nazir, de Keizer, Nicolette, Adhikari, Neill K J

“…Improvements in health-related outcomes for critically ill adults in low and lower-middle income countries need systematic investments in research capacity and…”
Get full text

Comparison of venovenous extracorporeal membrane oxygenation, prone position and supine mechanical ventilation for severely hypoxemic acute respiratory distress syndrome: a network meta-analysis by Sud, Sachin, Fan, Eddy, Adhikari, Neill K. J., Friedrich, Jan O., Ferguson, Niall D., Combes, Alain, Guerin, Claude, Guyatt, Gordon

“…Purpose Severe acute respiratory distress syndrome (ARDS) with PaO 2 /FiO 2  < 80 mmHg is a life-threatening condition. The optimal management strategy is…”
Get full text

Inhaled Nitric Oxide Does Not Reduce Mortality in Patients With Acute Respiratory Distress Syndrome Regardless of Severity: Systematic Review and Meta-Analysis by Adhikari, Neill K J, Dellinger, R Phillip, Lundin, Stefan, Payen, Didier, Vallet, Benoit, Gerlach, Herwig, Park, Kwang Joo, Mehta, Sangeeta, Slutsky, Arthur S, Friedrich, Jan O

“…OBJECTIVE:Treatment with inhaled nitric oxide improves oxygenation but not survival in mechanically ventilated patients with acute respiratory distress…”
Get full text

The effects of statin therapy on inflammatory cytokines in patients with bacterial infections: a randomized double-blind placebo controlled clinical trial by Novack, Victor, Eisinger, Miruna, Frenkel, Amit, Terblanche, Marius, Adhikari, Neill K. J., Douvdevani, Amos, Amichay, Doron, Almog, Yaniv

“…Objective To determine if statin therapy reduces the incidence of severe sepsis and the levels of inflammatory cytokines in patients with acute bacterial…”
Get full text