Search Results - "Adhikari, N."

Treatment of Ebola-related critical illness by Kiiza, Peter, Mullin, S., Teo, K., Adhikari, N. K. J., Fowler, R. A.

“…Purpose To explore contemporary clincial case management of patients with Ebola virus disease. Methods A narrative review from a clinical perspective of…”
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Gene‐specific features enhance interpretation of mutational impact on acid α‐glucosidase enzyme activity by Adhikari, Aashish N.

“…We present a computational model for predicting mutational impact on enzymatic activity of human acid α‐glucosidase (GAA), an enzyme associated with Pompe…”
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The role of exome sequencing in newborn screening for inborn errors of metabolism by Adhikari, Aashish N., Gallagher, Renata C., Wang, Yaqiong, Currier, Robert J., Amatuni, George, Bassaganyas, Laia, Chen, Flavia, Kundu, Kunal, Kvale, Mark, Mooney, Sean D., Nussbaum, Robert L., Randi, Savanna S., Sanford, Jeremy, Shieh, Joseph T., Srinivasan, Rajgopal, Sunderam, Uma, Tang, Hao, Vaka, Dedeepya, Zou, Yangyun, Koenig, Barbara A., Kwok, Pui-Yan, Risch, Neil, Puck, Jennifer M., Brenner, Steven E.

“…Public health newborn screening (NBS) programs provide population-scale ascertainment of rare, treatable conditions that require urgent intervention. Tandem…”
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A phase II trial of response adapted whole brain radiotherapy after high dose methotrexate based chemotherapy in patients with newly diagnosed primary central nervous system lymphoma by Adhikari, N., Biswas, A.

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Band gap tunning in BN-doped graphene systems with high carrier mobility by Kaloni, T. P., Joshi, R. P., Adhikari, N. P., Schwingenschlögl, U.

“…Using density functional theory, we present a comparative study of the electronic properties of BN-doped graphene monolayer, bilayer, trilayer, and multilayer…”
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Clinical and echocardiographic predictors of embolism in infective endocarditis: systematic review and meta-analysis by Yang, A., Tan, C., Daneman, N., Hansen, M.S., Habib, G., Salaun, E., Lavoute, C., Hubert, S., Adhikari, N.K.J.

“…Prediction of embolic events (EEs) in infective endocarditis (IE) could inform clinical decisions, such as surgical timing. We conducted a systematic review to…”
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Conventional and Molecular Breeding Tools for Accelerating Genetic Gain in Faba Bean ( Vicia Faba L.) by Adhikari, Kedar N, Khazaei, Hamid, Ghaouti, Lamiae, Maalouf, Fouad, Vandenberg, Albert, Link, Wolfgang, O'Sullivan, Donal M

“…Faba bean is a cool-season grain legume crop, which is grown worldwide for food and feed. Despite a decrease in area under faba bean in the past, the interest…”
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Comparative genomics reveals insight into virulence strategies of plant pathogenic oomycetes by Adhikari, Bishwo N, Hamilton, John P, Zerillo, Marcelo M, Tisserat, Ned, Lévesque, C André, Buell, C Robin

“…The kingdom Stramenopile includes diatoms, brown algae, and oomycetes. Plant pathogenic oomycetes, including Phytophthora, Pythium and downy mildew species,…”
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The Use of Whole Genome and Exome Sequencing for Newborn Screening: Challenges and Opportunities for Population Health by Woerner, Audrey C., Gallagher, Renata C., Vockley, Jerry, Adhikari, Aashish N.

“…Newborn screening (NBS) is a population-based program with a goal of reducing the burden of disease for conditions with significant clinical impact on…”
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A comparative quantitative structural assessment of benzothiazine-derived HDAC8 inhibitors by predictive ligand-based drug designing approaches by Banerjee, S., Baidya, S.K., Adhikari, N., Jha, T.

“…Histone deacetylase 8 (HDAC8) is a verified biomolecular target associated with diverse diseases including cancer. Though several HDAC inhibitors emerged…”
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ClinVar and HGMD genomic variant classification accuracy has improved over time, as measured by implied disease burden by Sharo, Andrew G, Zou, Yangyun, Adhikari, Aashish N, Brenner, Steven E

“…Curated databases of genetic variants assist clinicians and researchers in interpreting genetic variation. Yet, these databases contain some misclassified…”
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PhytoPipe: a phytosanitary pipeline for plant pathogen detection and diagnosis using RNA-seq data by Hu, Xiaojun, Hurtado-Gonzales, Oscar P, Adhikari, Bishwo N, French-Monar, Ronald D, Malapi, Martha, Foster, Joseph A, McFarland, Clint D

“…Detection of exotic plant pathogens and preventing their entry and establishment are critical for the protection of agricultural systems while securing the…”
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Assessing structural insights into in-house arylsulfonyl L-(+) glutamine MMP-2 inhibitors as promising anticancer agents through structure-based computational modelling approaches by Baidya, S.K., Banerjee, S., Ghosh, B., Jha, T., Adhikari, N.

“…MMP-2 is potentially contributing to several cancer progressions including leukaemias. Therefore, considering MMP-2 as a promising target, novel anticancer…”
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Pharmacological treatments for acute respiratory distress syndrome: systematic review by Duggal, A, Ganapathy, A, Ratnapalan, M, Adhikari, N K

“…Our objective was to systematically review the effect of pharmacological therapies on mortality in patients with acute respiratory distress syndrome (ARDS),…”
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Degeneration of aflatoxin gene clusters in Aspergillus flavus from Africa and North America by Adhikari, Bishwo N., Bandyopadhyay, Ranajit, Cotty, Peter J.

“…Aspergillus flavus is the most common causal agent of aflatoxin contamination of food and feed. However, aflatoxin-producing potential varies widely among A…”
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Hierarchical Modeling of Polystyrene: From Atomistic to Coarse-Grained Simulations by Harmandaris, V. A, Adhikari, N. P, van der Vegt, N. F. A, Kremer, K

“…We present a hierarchical approach that combines atomistic and mesoscopic simulations that can generally be applied to vinyl polymers. As a test case, the…”
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Pinpointing prime structural attributes of potential MMP-2 inhibitors comprising alkyl/arylsulfonyl pyrrolidine scaffold: a ligand-based molecular modelling approach validated by molecular dynamics simulation analysis by Baidya, S.K., Banerjee, S., Ghosh, B., Jha, T., Adhikari, N.

“…MMP-2 overexpression is strongly related to several diseases including cancer. However, none of the MMP-2 inhibitors have been marketed as drug candidates due…”
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Novel Echarate Virus Variant Isolated from Patient with Febrile Illness, Chanchamayo, Peru by Troncos, Gilda, Popuche, Dina, Adhikari, Bishwo N, Long, Kyle A, Rios, Jane, Valerio, Michel, Guevara, Carolina, Cer, Regina Z, Bishop-Lilly, Kimberly A, Ampuero, Julia S, Silva, Maria, Cruz, Cristhopher D

“…A new phlebovirus variant was isolated from an acute febrile patient in Chanchamayo, Peru. Genome characterization and p-distance analyses based on complete…”
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Complete genome sequence of zoysia mosaic virus, a novel member of the genus Poacevirus by Adhikari, Bishwo N., Zhou, Jing, Hu, Xiaojun, Turner, Roy S., McFarland, Clint, Foster, Joseph A.

“…Here, we report the detection and characterization of the genome of a novel poacevirus isolated from Zoysia matrella (Merrill) imported into the United States…”
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Exploring crucial structural attributes of quinolinyl methoxyphenyl sulphonyl-based hydroxamate derivatives as ADAM17 inhibitors through classification-dependent molecular modelling approaches by Samoi, T.B., Banerjee, S., Ghosh, B., Jha, T., Adhikari, N.

“…A Disintegrin and Metalloproteinase 17 (ADAM17), a Zn 2+ -dependent metalloenzyme of the adamalysin family of the metzincin superfamily, is associated with…”
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