Search Results - "Adhikari, Abhinav"

Myogenin is required for assembly of the transcription machinery on muscle genes during skeletal muscle differentiation by Adhikari, Abhinav, Kim, William, Davie, Judith

“…Skeletal muscle gene expression is governed by the myogenic regulatory family (MRF) which includes MyoD (MYOD1) and myogenin (MYOG). MYOD1 and MYOG are known…”
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JARID2 and the PRC2 complex regulate skeletal muscle differentiation through regulation of canonical Wnt signaling by Adhikari, Abhinav, Davie, Judith

“…JARID2 is a non-catalytic member of the polycomb repressive complex 2 (PRC2), which is known to regulate developmental target genes in embryonic stem cells…”
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The transcription elongation factor TCEA3 promotes the activity of the myogenic regulatory factors by Kazim, Noor, Adhikari, Abhinav, Davie, Judith

“…The transcription elongation factor TFIIS is encoded by a three member gene family in vertebrates. Here we show that one member of this family, TCEA3, is…”
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The transcription elongation factor TCEA3 induces apoptosis in rhabdomyosarcoma by Kazim, Noor, Adhikari, Abhinav, Oh, Teak Jung, Davie, Judith

“…TCEA3 is one of three genes representing the transcription elongation factor TFIIS family in vertebrates. TCEA3 is upregulated during skeletal muscle…”
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TBX3 represses TBX2 under the control of the PRC2 complex in skeletal muscle and rhabdomyosarcoma by Oh, Teak-Jung, Adhikari, Abhinav, Mohamad, Trefa, Althobaiti, Aiysha, Davie, Judith

“…TBX2 and TBX3 function as repressors and are frequently implicated in oncogenesis. We have shown that TBX2 represses p21, p14/19, and PTEN in rhabdomyosarcoma…”
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Endothelial cells metabolically regulate breast cancer invasion toward a microvessel by Tan, Matthew L., Jenkins-Johnston, Niaa, Huang, Sarah, Schutrum, Brittany, Vadhin, Sandra, Adhikari, Abhinav, Williams, Rebecca M., Zipfel, Warren R., Lammerding, Jan, Varner, Jeffrey D., Fischbach, Claudia

“…Breast cancer metastasis is initiated by invasion of tumor cells into the collagen type I-rich stroma to reach adjacent blood vessels. Prior work has…”
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Effective Biophysical Modeling of Cell Free Transcription and Translation Processes by Adhikari, Abhinav, Vilkhovoy, Michael, Vadhin, Sandra, Lim, Ha Eun, Varner, Jeffrey D

“…Transcription and translation are at the heart of metabolism and signal transduction. In this study, we developed an effective biophysical modeling approach to…”
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JARID2 Regulates Skeletal Muscle Differentiation through Regulation of Canonical Wnt Signaling Pathway by Adhikari, Abhinav, Davie, Judy

“…Myogenesis is a tightly regulated process that is dependent on the precise and dynamic integration of signals from various signaling pathways including the…”
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JARID2 and the PRC2 complex regulate the cell cycle in skeletal muscle by Adhikari, Abhinav, Mainali, Pramish, Davie, Judith K.

“…JARID2 is a noncatalytic member of the polycomb repressive complex 2 (PRC2) which methylates of histone 3 lysine 27 (H3K27). In this work, we show that JARID2…”
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The PRC2 complex directly regulates the cell cycle and controls proliferation in skeletal muscle by Adhikari, Abhinav, Davie, Judith K.

“…The polycomb repressive complex 2 (PRC2) is an important developmental regulator responsible for the methylation of histone 3 lysine 27 (H3K27). Here, we show…”
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Bioluminescence Resonance Energy Transfer (BRET)-Mediated Protein Release from Self-Illuminating Photoresponsive Biomaterials by Rapp, Teresa L., Kopyeva, Irina, Adhikari, Abhinav, DeForest, Cole A.

“…Phototriggered release of various cargos, including soluble protein factors and small molecules, has the potential to correct aberrant biological events by…”
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Design and Implementation of a Glucose-Responsive Genetic Switch Circuit in Cell-Free Systems for the Management of Diabetes by Adhikari, Abhinav

“…Cell-free protein synthesis (CFPS) systems are a widely used research tool in systems and synthetic biology and a promising platform for manufacturing of…”
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Wnt deregulation in rhabdomyosarcoma by Adhikari, Abhinav, Davie, Judith

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EGR1 interacts with TBX2 and functions as a tumor suppressor in rhabdomyosarcoma by Mohamad, Trefa, Kazim, Noor, Adhikari, Abhinav, Davie, Judith K

“…EGR1, one of the immediate-early response genes, can function as a tumor suppressor gene or as an oncogene in cancer. The function of EGR1 has not been fully…”
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Computational study of vortex shedding and its effects on asymmetrical airfoil with gurney flap by Mandal, Balram, Gupta, Roshani Kumari, Adhikari, Abhinav, Sheth, Mit Manojbhai, Bhoraniya, Rameshkumar, Harichandan, Atal Bihari

“…The rise in airport and airline operations has increased compelling interest in aircraft noise. The aerodynamic noise initiated by the high-lifting devices is…”
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Therapeutic targeting of LCK tyrosine kinase and mTOR signaling in T-cell acute lymphoblastic leukemia by Laukkanen, Saara, Veloso, Alexandra, Yan, Chuan, Oksa, Laura, Alpert, Eric J., Do, Daniel, Hyvärinen, Noora, McCarthy, Karin, Adhikari, Abhinav, Yang, Qiqi, Iyer, Sowmya, Garcia, Sara P., Pello, Annukka, Ruokoranta, Tanja, Moisio, Sanni, Adhikari, Sadiksha, Yoder, Jeffrey A., Gallagher, Kayleigh, Whelton, Lauren, Allen, James R., Jin, Alex H., Loontiens, Siebe, Heinäniemi, Merja, Kelliher, Michelle, Heckman, Caroline A., Lohi, Olli, Langenau, David M.

“…•Temsirolimus mTORC1 inhibitor and dasatinib kinase inhibitor synergize to kill a large fraction of xenograft and primary human T-ALL.•The LCK kinase, which is…”
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Constructing Cell-Free Expression Systems for Low-Cost Access by Guzman-Chavez, Fernando, Arce, Anibal, Adhikari, Abhinav, Vadhin, Sandra, Pedroza-Garcia, Jose Antonio, Gandini, Chiara, Ajioka, Jim W., Molloy, Jenny, Sanchez-Nieto, Sobeida, Varner, Jeffrey D., Federici, Fernan, Haseloff, Jim

“…Cell-free systems for gene expression have gained attention as platforms for the facile study of genetic circuits and as highly effective tools for teaching…”
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Proteasomal Regulation of Mammalian SPT16 in Controlling Transcription by Kaja, Amala, Adhikari, Abhinav, Karmakar, Saswati, Zhang, Wanwei, Rothschild, Gerson, Basu, Uttiya, Batra, Surinder K., Davie, Judith K., Bhaumik, Sukesh R.

“…FACT ( fa cilitates c hromatin t ranscription), an essential and evolutionarily conserved heterodimer from yeast to humans, controls transcription and is found…”
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The Role of Polycomb Repressive Complex-2 (PRC2) Mediated Regulation of Skeletal Muscle Proliferation and Differentiation by JARID2 by Adhikari, Abhinav

“…Eukaryotic DNA is packaged into highly ordered structures knows as chromatin that further packs the DNA into higher-order structures, limiting the…”
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IFN-γ and CIITA modulate IL-6 expression in skeletal muscle by Adhikari, Abhinav, Cobb, Brittan, Eddington, Seth, Becerra, Nathalie, Kohli, Punit, Pond, Amber, Davie, Judith

“…Interleukin 6 (IL-6) is a secreted cytokine that is an important mediator of the immune response in numerous tissues, including skeletal muscle. IL-6 is…”
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