Search Results - "Ader, I"

Revisiting the Hallmarks of Aging to Identify Markers of Biological Age by Guerville, Florent, De Souto Barreto, P., Ader, I., Andrieu, S., Casteilla, L., Dray, C., Fazilleau, N., Guyonnet, S., Langin, D., Liblau, R., Parini, A., Valet, P., Vergnolle, N., Rolland, Y., Vellas, B.

“…The Geroscience aims at a better understanding of the biological processes of aging, to prevent and/or delay the onset of chronic diseases and disability as…”
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A gerophysiology perspective on healthy ageing by Kemoun, Ph, Ader, I., Planat-Benard, V., Dray, C., Fazilleau, N., Monsarrat, P., Cousin, B., Paupert, J., Ousset, M., Lorsignol, A., Raymond-Letron, I., Vellas, B., Valet, P., Kirkwood, T., Beard, J., Pénicaud, L., Casteilla, L.

“…Improvements in public health and health care have resulted in significant increases in lifespan globally, but also in a significant increase in chronic…”
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Essential role for SphK1/S1P signaling to regulate hypoxia-inducible factor 2α expression and activity in cancer by Bouquerel, P, Gstalder, C, Müller, D, Laurent, J, Brizuela, L, Sabbadini, R A, Malavaud, B, Pyronnet, S, Martineau, Y, Ader, I, Cuvillier, O

“…The sphingosine kinase-1/sphingosine 1-phosphate (SphK1/S1P) signaling pathway has been reported to modulate the expression of the canonical transcription…”
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The INSPIRE Research Initiative: A Program for GeroScience and Healthy Aging Research Going from Animal Models to Humans and the Healthcare System by de Souto Barreto, P, Guyonnet, S, Ader, I, Andrieu, S, Casteilla, L, Davezac, N, Dray, C, Fazilleau, N, Gourdy, P, Liblau, R, Parini, A, Payoux, P, Pénicaud, L, Rampon, C, Rolland, Y, Valet, P, Vergnolle, N, Vellas, B

“…Aging is the most important risk factor for the onset of several chronic diseases and functional decline. Understanding the interplays between biological aging…”
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The INSPIRE Bio-Resource Research Platform for Healthy Aging and Geroscience: Focus on the Human Translational Research Cohort (The INSPIRE-T Cohort) by Guyonnet, S, Rolland, Y, Takeda, C, Ousset, P-J, Ader, I, Davezac, N, Dray, C, Fazilleau, N, Gourdy, P, Liblau, R, Parini, A, Payoux, P, Pénicaud, L, Rampon, C, Valet, P, Vergnolle, N, Andrieu, S, de Souto Barreto, P, Casteilla, L, Vellas, B

“…The Geroscience field focuses on the core biological mechanisms of aging, which are involved in the onset of age-related diseases, as well as declines in…”
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Healthy Aging Biomarkers: The INSPIRE's Contribution by Ader, I, Pénicaud, L, Andrieu, S, Beard, J R, Davezac, N, Dray, C, Fazilleau, N, Gourdy, P, Guyonnet, S, Liblau, R, Parini, A, Payoux, P, Rampon, C, Raymond-Letron, I, Rolland, Y, de Souto Barreto, P, Valet, P, Vergnolle, N, Sierra, F, Vellas, B, Casteilla, L

“…The find solutions for optimizing healthy aging and increase health span is one of the main challenges for our society. A novel healthcare model based on…”
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1163 POSTER A Therapeutic Sphingosine 1-phosphate Antibody Inhibits Intratumoral Hypoxia and Sensitizes to Standard Chemotherapy in a Preclinical Model of Prostate Cancer by Cuvillier, O, Ader, I, Bouquerel, P, Malavaud, B, Sabbadini, R.A

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Farnesylated RhoB inhibits radiation-induced mitotic cell death and controls radiation-induced centrosome overduplication by Milia, J, Teyssier, F, Dalenc, F, Ader, I, Delmas, C, Pradines, A, Lajoie-Mazenc, I, Baron, R, Bonnet, J, Cohen-Jonathan, E, Favre, G, Toulas, C

“…Our previous results demonstrated that expressing the GTPase ras homolog gene family, member B (RhoB) in radiosensitive NIH3T3 cells increases their survival…”
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42 A therapeutic sphingosine 1-phosphate antibody inhibits intratumoural hypoxia and sensitizes to chemotherapy in prostate cancer animal model by Cuvillier, O, Ader, I, Bouquerel, P, Golzio, M, Malavaud, B, Sabbadini, R.A

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486 The sphingosine kinase-1 survival pathway is a molecular target for the tumour-suppressive tea and wine polyphenols in prostate cancer by Brizuela Madrid, L, Dayon, A, Doumerc, N, Ader, I, Izard, J.C, Malavaud, B, Cuvillier, O

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Inhibition of the GTPase Rac1 mediates the antimigratory effects of metformin in prostate cancer cells by Dirat, Béatrice, Ader, Isabelle, Golzio, Muriel, Massa, Fabienne, Mettouchi, Amel, Laurent, Kathiane, Larbret, Frédéric, Malavaud, Bernard, Cormont, Mireille, Lemichez, Emmanuel, Cuvillier, Olivier, Tanti, Jean François, Bost, Frédéric

“…Cell migration is a critical step in the progression of prostate cancer to the metastatic state, the lethal form of the disease. The antidiabetic drug…”
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Osteoblast-derived sphingosine 1-phosphate to induce proliferation and confer resistance to therapeutics to bone metastasis-derived prostate cancer cells by Brizuela, Leyre, Martin, Claire, Jeannot, Pauline, Ader, Isabelle, Gstalder, Cécile, Andrieu, Guillaume, Bocquet, Magalie, Laffosse, Jean-Michel, Gomez-Brouchet, Anne, Malavaud, Bernard, Sabbadini, Roger A., Cuvillier, Olivier

“…Sphingosine 1-phosphate (S1P) plays important roles in cell proliferation, differentiation or survival mainly through its surface G-protein-coupled receptors…”
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Effect of a therapeutic sphingosine 1-phosphate antibody on intratumoral hypoxia and sensitivity to standard chemotherapy in prostate cancer animal model by Cuvillier, O., Ader, I., Bouquerel, P., Malavaud, B., Sabbadini, R. A.

“…Abstract only 24 Background: Hypoxia promotes neovascularization, metastasis, growth and resistance to treatments. The activation of HIF-1α has been identified…”
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Towards a Large-Scale Assessment of the Relationship between Biological and Chronological Aging: The INSPIRE Mouse Cohort by Santin, Y, Lopez, S, Ader, I, Andrieu, S, Blanchard, N, Carrière, A, Casteilla, L, Cousin, B, Davezac, N, De Souto Barreto, P, Dray, C, Fazilleau, N, Gonzalez-Dunia, D, Gourdy, P, Guyonnet, S, Jabrane-Ferrat, N, Kunduzova, O, Lezoualc'h, F, Liblau, R, Martinez, L O, Moro, C, Payoux, P, Pénicaud, L, Planat-Bénard, V, Rampon, C, Rolland, Y, Schanstra, J-P, Sierra, F, Valet, P, Varin, A, Vergnolle, N, Vellas, B, Viña, J, Guiard, B P, Parini, A

“…Aging is the major risk factor for the development of chronic diseases. After decades of research focused on extending lifespan, current efforts seek primarily…”
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Is Adherence to Imatinib Mesylate Treatment Among Patients with Chronic Myeloid Leukemia Associated with Better Clinical Outcomes in Qatar? by Al-Dewik, Nader I., Morsi, Hisham M., Samara, Muthanna M., Ghasoub, Rola S., Gnanam, Cinquea C., Bhaskaran, Subi K., Nashwan, Abdulqadir J., Al-Jurf, Rana M., Ismail, Mohamed A., Alsharshani, Mohammed M., Alsayab, Ali A., Ben-Omran, Tawfeg I., Khatib, Rani B., Yassin, Mohamed A.

“…Background: Despite the revolutionary success of introducing tyrosine kinase inhibitors (TKIs), such as imatinib mesylate (IM), for treating chronic myeloid…”
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Targeting FGFR-1 Pathways by the Antagonist SSR128129E Overcomes the Radioresistance of Human Glioma In Vitro and In Vivo by Cohen-Jonathan Moyal, E., Ader, I., Delmas, C., Skuli, N., Darlot, F., Bonnet, J., Favre, G., Bono, F., Toulas, C.

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Essential role for SphK1/S1P signaling to regulate hypoxia-inducible factor 2[alpha] expression and activity in cancer by Bouquerel, P, Gstalder, C, Müller, D, Laurent, J, Brizuela, L, Sabbadini, R A, Malavaud, B, Pyronnet, S, Martineau, Y, Ader, I, Cuvillier, O

“…The sphingosine kinase-1/sphingosine 1-phosphate (SphK1/S1P) signaling pathway has been reported to modulate the expression of the canonical transcription…”
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Targeting FGFR-1 Pathways by the Antagonist SSR128129E Overcomes the Radioresistance of Human Glioma In Vitro a nd In Vivo by Cohen-Jonathan Moyal, E, Ader, I, Delmas, C, Skuli, N, Darlot, F, Bonnet, J, Favre, G, Bono, F, Toulas, C

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Inhibition of Rho pathways induces radiosensitization and oxygenation in human glioblastoma xenografts by ADER, Isabelle, DELMAS, Caroline, BONNET, Jacques, ROCHAIX, Philippe, FAVRE, Gilles, TOULAS, Christine, COHEN-JONATHAN-MOYAL, Elizabeth

“…We previously demonstrated in vitro that inhibiting the biological pathways of the small GTPase Rho radiosensitizes the human glioma U87 cell line. The aim of…”
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The radioprotective effect of the 24 kDa FGF-2 isoform in HeLa cells is related to an increased expression and activity of the DNA dependent protein kinase (DNA-PK) catalytic subunit by ADER, Isabelle, MULLER, Catherine, BONNET, Jacques, FAVRE, Gilles, COHEN-JONATHAN, Elizabeth, SALLES, Bernard, TOULAS, Christine

“…We previously reported that overexpression of the 24 kDa basic fibroblast factor (or FGF-2) isoform provides protection from the cytotoxic effect of ionizing…”
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